2020
Exercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy
Fava A, Alashi A, Saijo Y, Mathias I, Popovic Z, Thamilarasan M, Lever H, Desai M. Exercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy. European Heart Journal 2020, 41: ehaa946.0081. DOI: 10.1093/ehjci/ehaa946.0081.Peer-Reviewed Original ResearchLV-GLSHypertrophic cardiomyopathyExercise capacityHCM patientsVentricular global longitudinal strainGlobal myocardial strainSymptomatic HCM patientsReduced exercise capacitySubclinical cardiac dysfunctionSubclinical myocardial dysfunctionGlobal longitudinal strainLVOT gradientCardiac deteriorationExercise impairmentCardiac dysfunctionMyocardial dysfunctionMaximal exerciseExercise testExercise variablesClinical utilityFunctional capacityPatientsMyocardial strainLogistic regressionLongitudinal strainCharacteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function
Alashi A, Isaza N, Faulx J, Popovic ZB, Menon V, Ellis SG, Faulx M, Kapadia SR, Griffin BP, Desai MY. Characteristics and Outcomes of Patients With Takotsubo Syndrome: Incremental Prognostic Value of Baseline Left Ventricular Systolic Function. Journal Of The American Heart Association 2020, 9: e016537. PMID: 32755253, PMCID: PMC7660826, DOI: 10.1161/jaha.120.016537.Peer-Reviewed Original ResearchConceptsBaseline LV ejection fractionLV ejection fractionIncremental prognostic valueLV-GLSTakotsubo syndromePrognostic valueLower baseline LV ejection fractionObstructive coronary artery diseaseVentricular global longitudinal strainMultivariate Cox survival analysisMean LV ejection fractionWorse LV-GLSOutcomes of patientsPrimary end pointVentricular systolic functionCoronary artery diseaseGlobal longitudinal strainLong-term outcomesCox survival analysisPhysical triggersPrognostic cutoffCause mortalityApical ballooningConclusions PatientsSystolic function
2019
P1951Serial left ventricular global longitudinal strain and mortality in patients with Takotsubo cardiomyopathy
Isaza N, Alashi A, Faulx J, Popovic Z, Menon V, Faulx M, Griffin B, Desai M. P1951Serial left ventricular global longitudinal strain and mortality in patients with Takotsubo cardiomyopathy. European Heart Journal 2019, 40: ehz748.0698. DOI: 10.1093/eurheartj/ehz748.0698.Peer-Reviewed Original ResearchLV ejection fractionLong-term mortalityLV-GLSGlobal longitudinal strainTransthoracic echocardiographyFunctional recoveryLV global longitudinal strainMultivariable Cox survival analysisLarge single-center studyObstructive coronary artery diseaseVentricular global longitudinal strainHigher long-term mortalityLongitudinal strainMean troponin ISingle-center studyCoronary artery diseaseKaplan-Meier curvesCox survival analysisMajority of casesAnginal symptomsPrimary endpointAngiographic evaluationApical ballooningArtery diseaseEjection fractionLong-Term Outcomes After Aortic Valve Surgery in Patients With Asymptomatic Chronic Aortic Regurgitation and Preserved LVEF Impact of Baseline and Follow-Up Global Longitudinal Strain
Alashi A, Khullar T, Mentias A, Gillinov AM, Roselli EE, Svensson LG, Popovic ZB, Griffin BP, Desai MY. Long-Term Outcomes After Aortic Valve Surgery in Patients With Asymptomatic Chronic Aortic Regurgitation and Preserved LVEF Impact of Baseline and Follow-Up Global Longitudinal Strain. JACC Cardiovascular Imaging 2019, 13: 12-21. PMID: 30772216, DOI: 10.1016/j.jcmg.2018.12.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic ValveAortic Valve InsufficiencyAsymptomatic DiseasesChronic DiseaseEchocardiographyFemaleHeart Valve Prosthesis ImplantationHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionLV-GLS valuesChronic aortic regurgitationAortic valve surgeryAortic regurgitationGlobal longitudinal strainAV surgeryLV-GLSValve surgeryMean left ventricular ejection fractionAsymptomatic chronic aortic regurgitationChronic severe aortic regurgitationVentricular global longitudinal strainBetter long-term survivalHigher long-term mortalityLongitudinal strainPost-operative echocardiographySevere aortic regurgitationLong-term mortalityVentricular ejection fractionSubgroup of patientsLong-term survivalSubgroup of subjectsAV replacementBaseline echocardiography
2018
Exercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain
Mentias A, Alashi A, Naji P, Gillinov AM, Rodriguez LL, Mihaljevic T, Suri RM, Grimm RA, Svensson LG, Griffin BP, Desai MY. Exercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain. Cardiovascular Diagnosis And Therapy 2018, 8: 460-468. PMID: 30214861, PMCID: PMC6129839, DOI: 10.21037/cdt.2018.05.03.Peer-Reviewed Original ResearchRight ventricular systolic pressureLeft ventricular ejection fractionPrimary mitral regurgitationMean metabolic equivalentSignificant primary mitral regurgitationLV-GLSExercise capacityAsymptomatic patientsMitral regurgitationGlobal longitudinal left ventricular strainLeft ventricular global longitudinal strainMitral effective regurgitant orificeVentricular global longitudinal strainVentricular systolic pressureVentricular ejection fractionGlobal longitudinal strainFlail mitral leafletLeft ventricular strainEffective regurgitant orificeVelocity vector imagingVentricular strainEjection fractionIndependent predictorsSignificant arrhythmiasSystolic pressureNovel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement
Huded CP, Kusunose K, Shahid F, Goodman AL, Alashi A, Grimm RA, Gillinov AM, Johnston DR, Rodriguez LL, Popovic ZB, Sato K, Svensson LG, Griffin BP, Desai MY. Novel Echocardiographic Parameters in Patients With Aortic Stenosis and Preserved Left Ventricular Systolic Function Undergoing Surgical Aortic Valve Replacement. The American Journal Of Cardiology 2018, 122: 284-293. PMID: 29751954, DOI: 10.1016/j.amjcard.2018.03.359.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLeft ventricular ejection fractionAortic valve replacementSevere aortic stenosisLV-GLSAortic stenosisSTS scoreValve replacementVentricular stroke volume indexVentricular global longitudinal strainLeft ventricular systolic functionMultivariate Cox survival analysisValidation subgroupNovel echocardiographic parametersThoracic Surgeons scoreWorse LV-GLSStroke volume indexVentricular systolic functionVentricular ejection fractionGlobal longitudinal strainCox survival analysisHigher STS scoreLong-term survivalIncremental prognostic impactDerivation subgroup
2017
Incremental Prognostic Utility of Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
Alashi A, Mentias A, Abdallah A, Feng K, Gillinov AM, Rodriguez LL, Johnston DR, Svensson LG, Popovic ZB, Griffin BP, Desai MY. Incremental Prognostic Utility of Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. JACC Cardiovascular Imaging 2017, 11: 673-682. PMID: 28624411, DOI: 10.1016/j.jcmg.2017.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic Valve InsufficiencyAsymptomatic DiseasesBiomechanical PhenomenaChronic DiseaseDisease ProgressionEchocardiography, Doppler, ColorFemaleHumansMaleMiddle AgedMyocardial ContractionPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular ejection fractionAortic valve surgeryChronic aortic regurgitationLong-term mortalityGlobal longitudinal strainRight ventricular systolic pressureVentricular global longitudinal strainLV end-systolic dimensionLV-GLSVentricular systolic pressureEnd-systolic dimensionVentricular ejection fractionAortic regurgitationAsymptomatic patientsTerm mortalityValve surgerySTS scoreEjection fractionSystolic pressurePrognostic utilityLeft ventricular global longitudinal strainMultivariable Cox survival analysisSevere chronic aortic regurgitationLongitudinal strainMean STS score