2021
Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thickness
2019
Characteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography
Gentry JL, Parikh PK, Alashi A, Gillinov AM, Pettersson GB, Rodriguez LL, Popovic ZB, Sato K, Grimm RA, Kapadia SR, Tuzcu EM, Svensson LG, Griffin BP, Desai MY. Characteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography. Circulation Cardiovascular Imaging 2019, 12: e009062. PMID: 31203672, DOI: 10.1161/circimaging.119.009062.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressureTreadmill stress echocardiographyVentricular systolic pressureStress echocardiographySystolic pressureMetabolic equivalentsMV gradientMitral proceduresHigh mortalityThoracic Surgeons scoreLong-term survivalAsymptomatic patientsCause mortalityPrimary outcomeSurgeons scoreConsecutive patientsImproved survivalContemporary patientsMV proceduresPatientsEchocardiographySignificant MSSurvival analysisModerate MSMortality
2018
Characteristics and longer-term outcomes of paravalvular leak after aortic and mitral valve surgery
Shah S, Alashi A, Pettersson GB, Rodriguez LL, Gillinov AM, Grimm RA, Navia J, Kapadia SR, Svensson LG, Griffin BP, Desai MY. Characteristics and longer-term outcomes of paravalvular leak after aortic and mitral valve surgery. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 1785-1792.e1. PMID: 30414770, DOI: 10.1016/j.jtcvs.2018.08.096.Peer-Reviewed Original ResearchConceptsReoperative cardiac surgeryLong-term mortalityRight ventricular systolic pressureGreater paravalvular leakMitral valve surgeryVentricular systolic pressureParavalvular leakLong-term outcomesLong-term survivalSTS scoreMV surgeryValve surgeryInfectious etiologySystolic pressureMultivariable Cox survival analysisGreater long-term mortalityAortic paravalvular leakMean STS scoreThoracic Surgeons scoreMild paravalvular leakVentricular ejection fractionCox survival analysisExcellent perioperative outcomesPerioperative outcomesPrimary endpointExercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain
Mentias A, Alashi A, Naji P, Gillinov AM, Rodriguez LL, Mihaljevic T, Suri RM, Grimm RA, Svensson LG, Griffin BP, Desai MY. Exercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain. Cardiovascular Diagnosis And Therapy 2018, 8: 460-468. PMID: 30214861, PMCID: PMC6129839, DOI: 10.21037/cdt.2018.05.03.Peer-Reviewed Original ResearchRight ventricular systolic pressureLeft ventricular ejection fractionPrimary mitral regurgitationMean metabolic equivalentSignificant primary mitral regurgitationLV-GLSExercise capacityAsymptomatic patientsMitral regurgitationGlobal longitudinal left ventricular strainLeft ventricular global longitudinal strainMitral effective regurgitant orificeVentricular global longitudinal strainVentricular systolic pressureVentricular ejection fractionGlobal longitudinal strainFlail mitral leafletLeft ventricular strainEffective regurgitant orificeVelocity vector imagingVentricular strainEjection fractionIndependent predictorsSignificant arrhythmiasSystolic pressure
2017
Incremental Prognostic Utility of Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
Alashi A, Mentias A, Abdallah A, Feng K, Gillinov AM, Rodriguez LL, Johnston DR, Svensson LG, Popovic ZB, Griffin BP, Desai MY. Incremental Prognostic Utility of Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. JACC Cardiovascular Imaging 2017, 11: 673-682. PMID: 28624411, DOI: 10.1016/j.jcmg.2017.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic Valve InsufficiencyAsymptomatic DiseasesBiomechanical PhenomenaChronic DiseaseDisease ProgressionEchocardiography, Doppler, ColorFemaleHumansMaleMiddle AgedMyocardial ContractionPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular ejection fractionAortic valve surgeryChronic aortic regurgitationLong-term mortalityGlobal longitudinal strainRight ventricular systolic pressureVentricular global longitudinal strainLV end-systolic dimensionLV-GLSVentricular systolic pressureEnd-systolic dimensionVentricular ejection fractionAortic regurgitationAsymptomatic patientsTerm mortalityValve surgerySTS scoreEjection fractionSystolic pressurePrognostic utilityLeft ventricular global longitudinal strainMultivariable Cox survival analysisSevere chronic aortic regurgitationLongitudinal strainMean STS scoreAortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta
Masri A, Kalahasti V, Svensson LG, Alashi A, Schoenhagen P, Roselli EE, Johnston DR, Rodriguez LL, Griffin BP, Desai MY. Aortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta. Circulation Cardiovascular Imaging 2017, 10: e006249. PMID: 28592593, DOI: 10.1161/circimaging.116.006249.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnatomic LandmarksAortaAortic AneurysmAortic ValveAortographyBicuspid Aortic Valve DiseaseCause of DeathChi-Square DistributionComputed Tomography AngiographyDilatation, PathologicFemaleHeart Valve DiseasesHospital MortalityHumansKaplan-Meier EstimateMagnetic Resonance AngiographyMaleMiddle AgedMultidetector Computed TomographyMultivariate AnalysisOhioPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBicuspid aortic valve patientsProximal ascending aortaAortic valve patientsBicuspid aortic valveAortic areaCardiovascular deathAscending aortaAortic surgeryValve patientsAortic valveMultivariable Cox survival analysisRight ventricular systolic pressureLong-term cardiovascular mortalityContrast-enhanced thoracicThoracic Surgeons scoreSevere aortic stenosisVentricular systolic pressureCox survival analysisMagnetic resonance angiographyHeight ratioAortic regurgitationCardiovascular mortalitySurgeons scoreAortic stenosisImproved survival
2016
Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Primary Mitral Regurgitation and Preserved Systolic Function Undergoing Mitral Valve Surgery
Alashi A, Mentias A, Patel K, Gillinov AM, Sabik JF, Popović ZB, Mihaljevic T, Suri RM, Rodriguez LL, Svensson LG, Griffin BP, Desai MY. Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Primary Mitral Regurgitation and Preserved Systolic Function Undergoing Mitral Valve Surgery. Circulation Cardiovascular Imaging 2016, 9: e004451. PMID: 27342145, DOI: 10.1161/circimaging.115.004451.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesBiomarkersCardiac Surgical ProceduresChi-Square DistributionEchocardiographyFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMultivariate AnalysisMyocardial ContractionNatriuretic Peptide, BrainPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsTreatment OutcomeVentricular Function, LeftVentricular Function, RightVentricular PressureConceptsLeft ventricular ejection fractionMitral valve surgeryVentricular ejection fractionLog-transformed BNPThoracic Surgeons scoreBrain natriuretic peptidePrimary mitral regurgitationRight ventricular systolic pressureSignificant primary mitral regurgitationVentricular systolic pressureGlobal longitudinal strainIncremental prognostic utilityLV-GLSAsymptomatic patientsValve surgeryEjection fractionMitral regurgitationSurgeons scoreNatriuretic peptideSystolic pressurePrognostic utilityBaseline LV global longitudinal strainBaseline right ventricular systolic pressureMitral effective regurgitant orificeLV global longitudinal strain