2020
Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy
Alashi A, Smedira NG, Hodges K, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Desai MY. Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy. Journal Of The American Heart Association 2020, 10: e016210. PMID: 33342243, PMCID: PMC7955478, DOI: 10.1161/jaha.120.016210.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresCardiomyopathy, HypertrophicDissectionEarly Medical InterventionEchocardiography, StressExercise TestFemaleHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsVentricular outflow tract gradientObstructive coronary artery diseaseBetter long-term survivalSurgical myectomyOutflow tract gradientObstructive hypertrophic cardiomyopathyCoronary artery diseaseLong-term survivalClass ITract gradientEarly surgeryArtery diseaseHypertrophic cardiomyopathyLeft ventricular outflow tract gradientAppropriate internal defibrillator dischargePrimary composite end pointBasal septal thicknessClass I indicationsPrimary composite eventsHypertrophic obstructive cardiomyopathyComposite end pointLong-term outcomesComposite eventsEarly referralObstructive cardiomyopathy
2019
226Earlier surgical myectomy vs. waiting for a Class I indication is associated with improved long-term survival in symptomatic hypertrophic obstructive cardiomyopathy patients
Alashi A, Smedira N, Hodges K, Popovic Z, Thamilarasan M, Wierup P, Lever H, Desai M. 226Earlier surgical myectomy vs. waiting for a Class I indication is associated with improved long-term survival in symptomatic hypertrophic obstructive cardiomyopathy patients. European Heart Journal 2019, 40: ehz747.0061. DOI: 10.1093/eurheartj/ehz747.0061.Peer-Reviewed Original ResearchClass I indicationsHypertrophic obstructive cardiomyopathySevere hypertrophic obstructive cardiomyopathySurgical myectomyHOCM patientsComposite endpointMedical therapySymptomatic hypertrophic obstructive cardiomyopathy patientsAppropriate internal defibrillator dischargeHypertrophic obstructive cardiomyopathy patientsVentricular outflow tract gradientImproved long-term survivalClass ILong-term event ratesBasal septal thicknessMaximal medical therapyOutflow tract gradientLong-term outcomesDeath risk scoreRisk survival analysisLong-term survivalExercise echoTract gradientExercise toleranceObstructive cardiomyopathy