2022
The Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients
Fadah K, Alashi A, Deoker A. The Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients. Current Cardiology Reports 2022, 24: 17-22. PMID: 35000149, DOI: 10.1007/s11886-021-01619-8.Peer-Reviewed Original ResearchConceptsDiabetic populationDiabetic patientsSGLT2 inhibitorsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsMajor adverse cardiovascular eventsReal-world cohort studyPeptide-1 receptor agonistsAdditional cardiovascular benefitsGLP-1RA therapyAdverse cardiovascular eventsCotransporter 2 inhibitorsMechanism of actionGLP-1RAsAntihyperglycemic therapyCardiac complicationsCardiac mortalityCardiovascular eventsCardiac outcomesCardiovascular benefitsCohort studyDrug therapyReceptor agonistCardioprotective processesReviewCardiovascular disease
2020
OP4 Perivascular fat attenuation index mapping around the right and left coronary artery independently predict cardiac mortality
Kotanidis C, Oikonomou E, Marwan M, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP4 Perivascular fat attenuation index mapping around the right and left coronary artery independently predict cardiac mortality. Heart 2020, 106: a2-a2. DOI: 10.1136/heartjnl-2020-bsci.4.Peer-Reviewed Original ResearchPerivascular fat attenuation indexFat attenuation indexCoronary arteryCoronary inflammationCardiac mortalityCardiac deathAnterior descending (LAD) coronary arteryEpicardial adipose tissue volumeFuture cardiac riskCox regression modelAdipose tissue volumeCross-sectional associationsAdipose tissue compositionMedian followProximal rightMultivariable adjustmentCardiac riskCoronary territoriesCoronary segmentsTomography angiographyIndependent associationHigh riskAverage ageArteryFuture incidenceOP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA
Kotanidis C, Oikonomou E, Marwan M, Kluener L, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA. Heart 2020, 106: a1-a2. DOI: 10.1136/heartjnl-2020-bsci.3.Peer-Reviewed Original ResearchFat attenuation indexHigh-risk plaquesPerivascular fat attenuation indexAdjusted riskCardiac riskHRP featuresHigh-risk plaque featuresMajor adverse cardiac eventsProximal right coronary arteryAdditive predictive valueAdverse cardiac eventsLow-attenuation plaqueRight coronary arteryCardiac risk stratificationCox regression modelNapkin-ring signAdipose tissue compositionCoronary inflammationCardiac mortalityInflammatory burdenCardiac eventsSpotty calcificationRisk stratificationPlaque featuresCoronary artery
2018
Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data
Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Centeno E, Thomas S, Herdman L, Kotanidis CP, Thomas KE, Griffin BP, Flamm SD, Antonopoulos AS, Shirodaria C, Sabharwal N, Deanfield J, Neubauer S, Hopewell JC, Channon KM, Achenbach S, Antoniades C. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. The Lancet 2018, 392: 929-939. PMID: 30170852, PMCID: PMC6137540, DOI: 10.1016/s0140-6736(18)31114-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueAdolescentAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFollow-Up StudiesHumansImaging, Three-DimensionalMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentSurvival AnalysisYoung AdultConceptsRight coronary arteryProximal right coronary arteryCardiac mortalityCoronary inflammationCoronary CTACoronary arteryDerivation cohortValidation cohortOutcome dataHealth Research Oxford Biomedical Research CentreCoronary artery disease indexHigh-risk plaque featuresPerivascular fat attenuation indexCoronary artery inflammationFat attenuation indexIntensive secondary preventionCardiovascular risk factorsResidual cardiovascular riskProspective outcome dataMajor coronary arteriesHounsfield unitsLeft circumflex arteryCox regression modelRisk predictionCardiac risk prediction