Featured Publications
Clinical impact of adjuvant radiation therapy delay after neoadjuvant chemotherapy in locally advanced breast cancer
Silva S, Pereira A, Marta G, de Barros Lima K, de Freitas T, Matutino A, de Azevedo Souza M, de Azevedo R, de Viveiros P, da Silva Lima J, Filassi J, de Andrade Carvalho H, Piato J, Mano M. Clinical impact of adjuvant radiation therapy delay after neoadjuvant chemotherapy in locally advanced breast cancer. The Breast 2017, 38: 39-44. PMID: 29223797, DOI: 10.1016/j.breast.2017.11.012.Peer-Reviewed Original ResearchConceptsPost-operative radiation therapyDisease-free survivalBetter disease-free survivalNeoadjuvant chemotherapyBreast cancerOverall survivalAdvanced breast cancerClinical stage IIIBetter overall survivalAdvanced BC patientsTherapy delayBC patientsClinical impactEarly initiationRadiation therapyStage IIIPatientsSurgeryOptimal timingWeeksChemotherapyFirm conclusionsCancerSurvivalInitiation
2016
Safety and Efficacy of a Modified FLOX Adjuvant Regimen for Patients With Stage III Colorectal Cancer Treated in the Community
Protásio B, Matutino A, Lage L, Santana I, Ramos R, Sabbaga J, Capareli F, Saragiotto D, Riechelmann R, Hoff P. Safety and Efficacy of a Modified FLOX Adjuvant Regimen for Patients With Stage III Colorectal Cancer Treated in the Community. Clinical Colorectal Cancer 2016, 16: 65-72. PMID: 27515842, DOI: 10.1016/j.clcc.2016.07.001.Peer-Reviewed Original ResearchConceptsStage III colorectal cancerColorectal cancerClinical trialsHigh riskResected stage III colorectal cancerLogistic regression multivariate analysisStage III CRC patientsDisease-free survivalPredictors of recurrenceRegression multivariate analysisAge 70 yearsLarge cancer centerAdjuvant chemotherapyAdjuvant oxaliplatinFit patientsNeurotoxicity gradeUrgent surgeryAdjuvant regimenAdverse eventsCohort studyCommunity patientsConsecutive patientsCRC patientsMedian agePrognostic factors
2014
Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial
Vilas-Boas A, Fontoura M, Xavier-Souza G, Araújo-Neto C, Andrade S, Brim R, Noblat L, Barral A, Cardoso M, Nascimento-Carvalho C, Matutino A, Barreto B, Silva C, Braga D, Oliveira F, Nogueira G, Oliveira Í, Lorgetto I, Costa I, Araripe J, Vieira J, Neiva L, Santana M, Nobre-Bastos M, Santos P, Câmara S, Carneiro S, Sirmos U, Araújo V, Silva C, Vilas-Boas C, Gantois D, Azevedo F, Maia J, Pirajá L, Jesus P, Fonseca T, Vilar T. Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial. Journal Of Antimicrobial Chemotherapy 2014, 69: 1954-1959. PMID: 24648506, DOI: 10.1093/jac/dku070.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAmoxicillinAnti-Bacterial AgentsBrazilChild, PreschoolFemaleHumansInfantMalePneumonia, BacterialTreatment OutcomeConceptsNon-severe pneumoniaTreatment failureOral amoxicillinFirst-line therapyChildhood pneumoniaPrimary outcomeTreat analysisRespiratory complaintsBlinded investigationDaily dosesChest radiographsPatient allocationPneumoniaPatientsIndependent radiologistsAmoxicillinProtocol analysisThriceMonthsChildrenParticipantsFailureConcordant readingsPlaceboTherapy
2010
Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin
Fontoura M, Araújo-Neto C, Andrade S, Brim R, Matutino A, Silva C, Santana M, Nobre-Bastos M, Oliveira F, Barreto B, Santos P, Noblat L, Cardoso M, Nascimento-Carvalho C, Group T. Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin. Expert Opinion On Pharmacotherapy 2010, 11: 1451-1458. PMID: 20408745, DOI: 10.1517/14656561003777034.Peer-Reviewed Original ResearchMeSH KeywordsAmoxicillinAnti-Bacterial AgentsChild, PreschoolCommunity-Acquired InfectionsHumansInfantPneumonia, BacterialTreatment OutcomeConceptsClinical failureDays of treatmentRisk factorsNonsevere community-acquired pneumoniaAdverse effect frequencyPersistence of feverRadiographic pulmonary infiltratesCommunity-acquired pneumoniaIndependent risk factorClinical failure rateNonsevere pneumoniaPulmonary infiltratesAdverse eventsPleural effusionRespiratory complaintsClinical findingsDifficulty breathingAdverse reactionsSevere diseasePneumonia diagnosisCystic fibrosisMultivariate analysisDemographic dataAmoxicillinOlder children