Platelet depletion in mice increases mortality after thermal injury
Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood 2006, 107: 4399-4406. PMID: 16467203, PMCID: PMC1895793, DOI: 10.1182/blood-2005-09-3776.Peer-Reviewed Original ResearchConceptsControl miceFull-thickness total body surface areaHost responseThermal injuryTotal body surface areaExperimental control miceSystemic inflammatory responsePlatelet-depleted miceRole of plateletsBody surface areaCause of deathCritical protective rolePeripheral blood monocytesImportance of plateletsSham injuryIL-6MCP-1Plasma levelsPlatelet depletionInflammatory responseImmune responseAdaptive immunityBlood monocytesMouse modelProtective role