2024
11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 1-7. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutism
2022
Predictability modulates neural response to eye contact in ASD
Naples AJ, Foss-Feig JH, Wolf JM, Srihari VH, McPartland JC. Predictability modulates neural response to eye contact in ASD. Molecular Autism 2022, 13: 42. PMID: 36309762, PMCID: PMC9618208, DOI: 10.1186/s13229-022-00519-0.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsNeural responsesAdult participantsAmplitude of N170Perception of gazeP300 event-related potentialExperiment twoN170 responseAnxiety symptomologyCognitive abilitiesNeural basisExperiment oneNeural processingASD sampleSpectrum disorderInterpersonal interactionsN170P300 responseAutistic womenEye contactEye trackingSocial interactionSocial contextSocial world