Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. Journal Of Clinical Investigation 2002, 109: 1321-1326. PMID: 12021247, PMCID: PMC150979, DOI: 10.1172/jci14955.Peer-Reviewed Original ResearchMeSH KeywordsAdultAspirinBlood GlucoseCyclooxygenase InhibitorsDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansI-kappa B KinaseMaleMiddle AgedProtein Serine-Threonine KinasesConceptsAspirin treatmentInsulin resistanceTolerance testPlasma glucoseInsulin-stimulated peripheral glucose uptakeHigh-dose aspirin treatmentMixed meal tolerance testType 2 diabetic subjectsMixed-meal tolerance testType 2 diabetes mellitusHigh-dose aspirinWeeks of treatmentC-reactive proteinPeripheral glucose uptakeHyperinsulinemic-euglycemic clampType 2 diabetesPlasma insulin concentrationHepatic glucose productionFatty acid levelsDiabetes mellitusDiabetic subjectsTotal cholesterolGlucose toleranceInsulin clearanceTissue inflammation