2024
Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence
Stulberg E, Lisabeth L, Schneider A, Skolarus L, Kershaw K, Zheutlin A, Harris B, Sarpong D, Wong K, Sheth K, de Havenon A. Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence. Annals Of Neurology 2024 PMID: 39056317, DOI: 10.1002/ana.27039.Peer-Reviewed Original ResearchSocioeconomic statusStroke prevalenceCounty-level socioeconomic statusSocioeconomic status measuresHealth care accessCenters for Disease Control and PreventionRisk factor measurementsDisease Control and PreventionPrevalence of adultsFederal poverty levelControl and PreventionCare accessStroke metricsStroke riskPoverty levelObservational researchPrevalenceClinical determinantsCommunity estimatesEcological studiesStrokeFactor measurementsHealthInterventionAdultsO-035 Higher endovascular thrombectomy procedural volume is associated with reduced inpatient mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Nowicki K, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Hebert R, Matouk C, de Havenon A. O-035 Higher endovascular thrombectomy procedural volume is associated with reduced inpatient mortality. 2024, a27.2-a28. DOI: 10.1136/jnis-2024-snis.35.Peer-Reviewed Original ResearchMobile stroke units: Beyond thrombolysis
Krothapalli N, Hasan D, Lusk J, Poli S, Hussain S, de Havenon A, Grotta J, Grory B. Mobile stroke units: Beyond thrombolysis. Journal Of The Neurological Sciences 2024, 463: 123123. PMID: 38981417, DOI: 10.1016/j.jns.2024.123123.Peer-Reviewed Original ResearchDisability and Recurrent Stroke Among Participants in Stroke Prevention Trials
de Havenon A, Viscoli C, Kleindorfer D, Sucharew H, Delic A, Becker C, Robinson D, Yaghi S, Li V, Lansberg M, Cramer S, Mistry E, Sarpong D, Kasner S, Kernan W, Sheth K. Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials. JAMA Network Open 2024, 7: e2423677. PMID: 39028666, PMCID: PMC11259901, DOI: 10.1001/jamanetworkopen.2024.23677.Peer-Reviewed Original ResearchConceptsPrevention trialsPoststroke disabilityRecurrent stroke ratesRecurrent strokeCohort studyRate of recurrent strokeStroke Prevention TrialIncreased hazardInsulin Resistance InterventionSecondary prevention trialsBaseline disabilityAssociated with increased ratesStroke rateMain OutcomesFunctional statusResistance InterventionStudy baselineSecondary outcomesPrimary outcomeWorsening heart failureModified Rankin ScaleProfession's participationLong-term followVascular deathDisabilityRisk factors for MACE and bleeding in atrial fibrillation patients undergoing surgery: Insights from the bridge trial
Shu L, Jack N, de Havenon A, Goldstein E, Khan F, Nguyen T, Henninger N, Siegler J, Stretz C, Perelstein E, Kala N, Rana M, Furie K, Douketis J, Yaghi S. Risk factors for MACE and bleeding in atrial fibrillation patients undergoing surgery: Insights from the bridge trial. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107839. PMID: 38944363, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107839.Peer-Reviewed Original ResearchMajor adverse cardiovascular eventsSymptomatic bleedingBridging therapyRisk factorsAtrial fibrillationLow-molecular-weight heparin bridging therapyTemporary interruption of warfarin therapyInterruption of warfarin therapyNonsteroidal anti-inflammatory drug useElective proceduresAnti-inflammatory drug useElective invasive proceduresHeparin bridging therapyRisk of adverse outcomesAdverse cardiovascular eventsPerioperative risk stratificationCox regression modelsIdentified risk factorsPost hoc analysisPatient undergoes surgeryLogistic stepwise regressionWarfarin therapyBridging anticoagulationAF patientsBleeding outcomesAnticoagulation Versus Antiplatelets in Spontaneous Cervical Artery Dissection: A Systematic Review and Meta-Analysis
Yaghi S, Shu L, Fletcher L, Fayad F, Shah A, Herning A, Isho N, Mansour P, Joudi K, Zaidat B, Mahmoud N, Khalek F, Xiao H, Goldstein E, Ghannam M, Siegler J, Omran S, Bakradze E, Nguyen T, Keser Z, Khan M, Shahripour R, de Havenon A, Henninger N, Heldner M, Field T, Aziz Y, Mistry E, Furie K, Engelter S, Markus H. Anticoagulation Versus Antiplatelets in Spontaneous Cervical Artery Dissection: A Systematic Review and Meta-Analysis. Stroke 2024, 55: 1776-1786. PMID: 38847098, DOI: 10.1161/strokeaha.124.047310.Peer-Reviewed Original ResearchConceptsCervical artery dissectionSystematic reviewArtery dissectionMeta-analysisBleeding riskIschemic stroke riskAntiplatelet therapyRandomized trialsSpontaneous cervical artery dissectionRisk of deathIschemic strokeCombination of keywordsTreated with antiplateletSafety of dual antiplatelet therapyReducing ischemic strokeSymptomatic intracranial hemorrhageOptimal antithrombotic strategyMajor traumaDual antiplatelet therapyIndividualized therapeutic approachStudy of patientsInclusion criteriaRandomized clinical trialsMeta-analysesEffect sizeStrokeClassifier: ischemic stroke etiology classification by ensemble consensus modeling using electronic health records
Lee H, Schwamm L, Sansing L, Kamel H, de Havenon A, Turner A, Sheth K, Krishnaswamy S, Brandt C, Zhao H, Krumholz H, Sharma R. StrokeClassifier: ischemic stroke etiology classification by ensemble consensus modeling using electronic health records. Npj Digital Medicine 2024, 7: 130. PMID: 38760474, PMCID: PMC11101464, DOI: 10.1038/s41746-024-01120-w.Peer-Reviewed Original ResearchElectronic health recordsWeighted F1MIMIC-IIIClinical decision support systemsMulti-class classificationNatural language processingMIMIC-III datasetHealth recordsMachine learning classifiersDecision support systemArtificial intelligence toolsVascular neurologistsLearning classifiersBinary classificationCross-validation accuracyLanguage processingMeta-modelIntelligence toolsStroke prevention effortsAcute ischemic strokeStroke etiologySupport systemStroke etiology classificationClassification toolClassifierPrediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research.
de Havenon A, Ayodele I, Alhanti B, Mac Grory B, Xian Y, Fonarow G, Smith E, Worrall B. Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research. Neurology 2024, 102: e209424. PMID: 38759133, PMCID: PMC11175650, DOI: 10.1212/wnl.0000000000209424.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionNIH Stroke ScaleConsistent with previous studiesAdult acute ischemic stroke patientsCross-sectional cohort analysisAcute ischemic stroke patientsLarge vessel occlusion strokePosterior circulation strokeDiagnosis of ischemic strokeReceiver operating curveNeuroimagingGWTG-StrokeIschemic stroke patientsVascular neuroimagingAdult patientsAtrial fibrillationCirculation strokeCohort analysisClinical covariatesStroke patientsOcclusion strokeVessel occlusionPrevious studiesCut-pointsStroke ScaleDiffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients
Sorby‐Adams A, Guo J, de Havenon A, Payabvash S, Sze G, Pinter N, Jaikumar V, Siddiqui A, Baldassano S, Garcia‐Guarniz A, Zabinska J, Lalwani D, Peasley E, Goldstein J, Nelson O, Schaefer P, Wira C, Pitts J, Lee V, Muir K, Nimjee S, Kirsch J, Iglesias J, Rosen M, Sheth K, Kimberly W. Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients. Annals Of Neurology 2024, 96: 321-331. PMID: 38738750, PMCID: PMC11293843, DOI: 10.1002/ana.26954.Peer-Reviewed Original ResearchStroke patientsAcute ischemic strokeCut-pointsIschemic strokeStroke patients <Diagnosis of acute ischemic strokeSignal intensity ratioFluid-attenuated inversion recoveryAcute stroke patientsOptimal cut-pointMagnetic resonance imagingDiffusion-weighted imagingDWI-FLAIR mismatchStroke onsetTrained assessorsNational InstituteStrokeThrombolytic interventionNegative predictive valueFLAIR hyperintensitiesPatientsInterobserver agreementHyperacute strokeDiffusion-weightedPredictive valueUse of a dedicated open transcarotid access system for neurovascular disease
Sujijantarat N, Renedo D, Antonios J, Koo A, Amllay A, Nowicki K, Cord B, Hebert R, de Havenon A, Sheth K, Petersen N, Matouk C. Use of a dedicated open transcarotid access system for neurovascular disease. Journal Of NeuroInterventional Surgery 2024, jnis-2024-021599. PMID: 38719442, DOI: 10.1136/jnis-2024-021599.Peer-Reviewed Original ResearchExtracranial carotid stenosisTranscarotid artery revascularizationNeurovascular diseasesCarotid stenosisDatabase of consecutive patientsNeurovascular pathologyTreatment of neurovascular diseasesAccess-related complicationsTreatment of neurovascular pathologiesOff-label useCarotid flow reversalConsecutive patientsRetrospective reviewIntracranial atherosclerotic diseasePeriprocedural complicationsEndovascular treatmentArtery revascularizationProcedural characteristicsArterial sheathCarotid diseaseAcademic centersIntracranial aneurysmsPatientsTranscarotid approachTransradial approach2024 AHA/ASA Performance and Quality Measures for Spontaneous Intracerebral Hemorrhage: A Report From the American Heart Association/American Stroke Association
Ruff I, de Havenon A, Bergman D, Dugue R, Frontera J, Goldstein J, Hemphill J, Marulanda-Londono E, Prabhakaran S, Richards C, Sunmonu N, Vilar P, Wolfe S. 2024 AHA/ASA Performance and Quality Measures for Spontaneous Intracerebral Hemorrhage: A Report From the American Heart Association/American Stroke Association. Stroke 2024, 55: e199-e230. PMID: 38695183, DOI: 10.1161/str.0000000000000464.Peer-Reviewed Original ResearchAmerican Heart Association/American Stroke AssociationStroke AssociationQuality measuresPosthospital settingPatient careStroke expertsData collectionWorking GroupPerformance measuresSpontaneous intracerebral hemorrhageAmericanGuidelinesIntracerebral hemorrhageAssociationPrehospitalCareAHA/ASAPotential challengesInterventionBlood Pressure and Cognitive Function in Older Adults
Littig L, Sheth K, Brickman A, Mistry E, de Havenon A. Blood Pressure and Cognitive Function in Older Adults. Clinics In Geriatric Medicine 2024 DOI: 10.1016/j.cger.2024.04.003.Peer-Reviewed Original ResearchSecondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure controlImpact of sleep quality and physical activity on blood pressure variability
de Havenon A, Falcone G, Rivier C, Littig L, Petersen N, de Villele P, Prabhakaran S, Kimberly W, Mistry E, Sheth K. Impact of sleep quality and physical activity on blood pressure variability. PLOS ONE 2024, 19: e0301631. PMID: 38625967, PMCID: PMC11020843, DOI: 10.1371/journal.pone.0301631.Peer-Reviewed Original ResearchConceptsSleep qualityPhysical activityOdds ratioCohort of community-dwelling adultsCommunity-dwelling adultsExcess relative riskBlood pressure variabilityExamined sleep qualityPoor sleep qualitySystolic blood pressure standard deviationSleep interruptionBody mass indexPhysical inactivityPrimary study outcomeStep countsImpact of sleep qualityLowest tertileRelative riskHigh blood pressure variabilityHome measurement devicesActivity levelsExposure statusPoor sleepMass indexStudy outcomesExternal validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis
Klein P, Shu L, Lindgren E, de Winter M, Siegler J, Simpkins A, Omran S, Heldner M, de Havenon A, Abdalkader M, Al Kasab S, Stretz C, Wu T, Wilson D, Asad S, Almallouhi E, Frontera J, Kuohn L, Rothstein A, Bakradze E, Henninger N, Zubair A, Sharma R, Kerrigan D, Aziz Y, Mistry E, van Kammen M, Tatlisumak T, Krzywicka K, Aguiar de Sousa D, Jood K, Field T, Yaghi S, Coutinho J, Nguyen T. External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107720. PMID: 38614162, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107720.Peer-Reviewed Original ResearchConceptsCerebral venous thrombosisArea under the receiver operating characteristic curvePoor outcomeVenous thrombosisCentral nervous system infectionInternational retrospective studyNervous system infectionExternal validation cohortFocal neurological deficitsReceiver operating characteristic curvePoor outcome dataLevels of hemoglobinLack of follow-upPoorer outcome scoresConsecutive patientsClinical presentationRetrospective studyValidation cohortIntracerebral hemorrhageNeurological deficitsFollow-upOutcome scoresSystemic infectionLevels of glucoseInternational cohortPolygenic Resistance to Blood Pressure Treatment and Stroke Risk (S6.001)
Huo S, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Zhao H, De Havenon A, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk (S6.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206202.Peer-Reviewed Original ResearchEnhanced Benefits of the Life’s Essential 8 in APOE Epsilon 4 Carriers (P3-5.014)
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Torres-Lopez V, De Havenon A, Sheth K, Gill T, Falcone G. Enhanced Benefits of the Life’s Essential 8 in APOE Epsilon 4 Carriers (P3-5.014). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206215.Peer-Reviewed Original ResearchLife’s Essential 8 and Brain Health Clinical Outcomes in Middle-aged Adults (P2-15.003)
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Torres-Lopez V, De Havenon A, Sheth K, Gill T, Falcone G. Life’s Essential 8 and Brain Health Clinical Outcomes in Middle-aged Adults (P2-15.003). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206195.Peer-Reviewed Original ResearchEpigenetic Age and Brain Health Events: Findings from the Health and Retirement Study (P2-9.004)
Rivier C, Szejko N, Renedo D, De Havenon A, Sheth K, Gill T, Falcone G. Epigenetic Age and Brain Health Events: Findings from the Health and Retirement Study (P2-9.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204975.Peer-Reviewed Original ResearchFactors Associated with Delayed Clinical Evaluation for Patients with Intracerebral Hemorrhage in the ERICH Study (S41.010)
Lalwani D, Zabinska J, Peasley E, De Havenon A, Falcone G, Goldstein J, Woo D, Sheth K. Factors Associated with Delayed Clinical Evaluation for Patients with Intracerebral Hemorrhage in the ERICH Study (S41.010). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204689.Peer-Reviewed Original Research