2023
Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes
de Havenon A, Zaidat O, Amin-Hanjani S, Nguyen T, Bangad A, Abbasi M, Anadani M, Almallouhi E, Chatterjee R, Mazighi M, Mistry E, Yaghi S, Derdeyn C, Hong K, Kvernland A, Leslie-Mazwi T, Al Kasab S. Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes. Stroke 2023, 54: 1695-1705. PMID: 36938708, PMCID: PMC10202848, DOI: 10.1161/strokeaha.122.040008.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresHumansIntracranial ArteriosclerosisRetrospective StudiesStrokeThrombectomyTreatment OutcomeConceptsLarge vessel occlusion strokeIntracranial atherosclerotic diseaseEndovascular thrombectomyAtherosclerotic diseaseOcclusion strokeFunctional outcome benefitsVascular risk factorsAdjunctive medicationsMedical managementPatient factorsInterventional treatmentOutcome benefitsRisk factorsObservational studyEarly identificationTreatment planningThrombectomyUnique considerationsPatientsStrokeLVODiseaseRevascularizationMedicationsReview
2022
Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Anadani M, Maier B, Escalard S, Labreuche J, de Havenon A, Sabben C, Lapergue B, Mistry EA, Gory B, Spiotta AM, Richard S, Sibon I, Desilles JP, Blanc R, Piotin M, Mazighi M. Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial. Journal Of NeuroInterventional Surgery 2022, 15: e142-e147. PMID: 36220337, DOI: 10.1136/jnis-2022-019130.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureBrain IschemiaEndovascular ProceduresHumansHypertensionStrokeTreatment OutcomeConceptsIntensive SBP treatmentHistory of hypertensionBlood pressure treatmentSuccessful endovascular therapyIntravenous thrombolysisLocation of occlusionEndovascular therapySBP treatmentAdmission SBPDiabetic patientsIntensive blood pressure loweringIntensive systolic blood pressureAcute ischemic stroke trialsTarget trialsEffect of SBPBlood pressure loweringNon-diabetic patientsFavorable functional outcomeSystolic blood pressureIschemic stroke trialsSite of occlusionIntensive SBPRecanalization statusSuccessful reperfusionBlood pressure
2021
Prestroke Disability and Outcome After Thrombectomy for Emergent Anterior Circulation Large Vessel Occlusion Stroke
de Havenon A, Castonguay A, Nogueira R, Nguyen TN, English J, Satti SR, Veznedaroglu E, Saver JL, Mocco J, Khatri P, Mistry E, Zaidat OO. Prestroke Disability and Outcome After Thrombectomy for Emergent Anterior Circulation Large Vessel Occlusion Stroke. Neurology 2021, 97: e1914-e1919. PMID: 34544817, PMCID: PMC8601211, DOI: 10.1212/wnl.0000000000012827.Peer-Reviewed Original ResearchMeSH KeywordsArterial Occlusive DiseasesBrain IschemiaEndovascular ProceduresHumansIschemic StrokeRetrospective StudiesStentsStrokeThrombectomyTreatment OutcomeConceptsPremorbid mRS scoreAnterior circulation acute ischemic strokeLarge vessel occlusion strokeAcute ischemic strokeEndovascular thrombectomyMRS scoreIschemic strokePrimary outcomeOcclusion strokeOdds ratioAnterior circulation large vessel occlusion strokeMiddle cerebral artery occlusionAcute Stroke RegistryCerebral artery occlusionClass II evidenceStudy of patientsPrestroke disabilityStroke RegistryArtery occlusionConsecutive patientsEndovascular therapyPremorbid disabilityFurther disabilityTrevo deviceMore disabilityEndovascular Therapy of Anterior Circulation Tandem Occlusions
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Siddiqui A, Ribo M, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, de Havenon A, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Turjman F, Piotin M, Steglich-Arnholm H, Holtmannspötter M, Taschner C, Eiden S, Haussen D, Boutchakova M, Dorn F, Killer-Oberpfalzer M, Mangiafico S, Psychogios M, Labeyrie M, Biondi A, Bracard S, Grossberg J, Guenego A, Darcourt J, Vukasinovic I, Pomero E, Davies J, Renieri L, Hecker C, Muchada M, Rodesch G, Houdart E, Lockau J, Kastrup A, Redjem H, Behme D, Shallwani H, Christopher M, Mione G, Humbertjean L, Riou-Comte N, Zhu F, Derelle A, Liao L, Piotin M, Redjem H, Escalard S, Maïer B, Desilles J, Ciccio G, Smajda S, Obadia M, Sabben C, Corabianu O, de Broucker T, Smadja D, Alamowitch S, Ille O, Manchon E, Garcia P, Taylor G, Maacha M, Wang A, Evrard S, Tchikviladze M, Ajili N, Weisenburger D, Gorza L, Coskun O, Di Maria F, Rodesh G, Leguen M, Gratieux J, Pico F, Rakotoharinandrasana H, Tassan P, Poll R, Marinier S, Gariel F, Barreau X, Berge J, Veunac L, Menegon P, Lucas L, Olindo S, Renou P, Sagnier S, Poli M, Debruxelles S, Tourdias T, Liegey J, Detraz L, Daumas-Duport B, Alexandre P, Roy M, Lenoble C, L’allinec V, Girot J, Desal H, Bechiri F, Bracard S, Braun M, Derelle A, Tonnelet R, Liao L, Zhu F, Schmitt E, Planel S, Humbertjean L, Mione G, Lacour J, Hossu G, Beaumont M, Bailang M, Reitter M, Masson A, Alb L, Tabarna A, Voicu M, Podar I, Brezeanu M, Guy S, Costalat V, Gascou G, Lefèvre P, Derraz I, Riquelme C, Gaillard N, Mourand I, Corti L. Endovascular Therapy of Anterior Circulation Tandem Occlusions. Stroke 2021, 52: 3097-3105. PMID: 34372671, DOI: 10.1161/strokeaha.120.033032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnterior Cerebral ArteryArterial Occlusive DiseasesCarotid Artery, InternalCarotid Artery, Internal, DissectionCerebral HemorrhageEndovascular ProceduresFemaleFranceHumansIntracranial ArteriosclerosisIschemic StrokeMaleMiddle AgedPatient SafetyPropensity ScoreRegistriesStentsStrokeThrombectomyTreatment OutcomeConceptsAnterior circulation tandem occlusionTandem occlusion strokeAcute ischemic strokeStent groupEndovascular therapyIntracerebral hemorrhageTandem occlusionsHigher oddsFavorable outcomeIschemic strokeOcclusion strokeTreatment approachesParenchymal hemorrhage type 2Internal carotid artery lesionsPropensity score-adjusted analysisAcute carotid stentingSymptomatic intracerebral hemorrhageCarotid artery lesionsIndividual patient dataBest treatment approachCurrent clinical practiceDifferent treatment approachesHigh rateSuccessful reperfusionAnterior circulationInvestigating the “Weekend Effect” on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke
Grandhi R, Ravindra VM, Ney JP, Zaidat O, Taussky P, de Havenon A. Investigating the “Weekend Effect” on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 106013. PMID: 34375859, PMCID: PMC8511062, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106013.Peer-Reviewed Original ResearchMeSH KeywordsAfter-Hours CareAgedAged, 80 and overCross-Sectional StudiesDatabases, FactualEndovascular ProceduresFemaleHospital CostsHospital MortalityHumansInpatientsIschemic StrokeLength of StayMaleMiddle AgedPatient DischargeRetrospective StudiesRisk AssessmentRisk FactorsThrombectomyTime FactorsTreatment OutcomeUnited StatesConceptsAcute ischemic strokeEndovascular thrombectomyIschemic strokeLarge vessel occlusion ischemic strokeHealth Stroke Scale scoreNationwide Inpatient Sample dataStroke Scale scoreExtended hospital stayWorse clinical outcomesCross-sectional analysisLogistic regression modelsHospital deathHospital staySecondary outcomesPrimary outcomeClinical outcomesAIS patientsNormal working hoursPatientsScale scoreFavorable dischargeExposure variablesStrokeWeekends/National InstitutePenumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial
Yaghi S, Raz E, Dehkharghani S, Riina H, McTaggart R, Jayaraman M, Prabhakaran S, Liebeskind DS, Khatri P, Mac Grory B, Al-Mufti F, Lansberg M, Albers G, de Havenon A. Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial. Stroke 2021, 52: 2690-2693. PMID: 34157865, DOI: 10.1161/strokeaha.120.033806.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsLarge vessel occlusionPenumbral tissueVessel occlusionMismatch volumeAcute large vessel occlusionAnterior circulation occlusionEndovascular thrombectomy patientsAcute ischemic strokePost Hoc AnalysisReperfusion statusThrombectomy patientsTICI 0Cerebral infarctionEndovascular thrombectomyIschemic strokeUntreated patientsPrimary outcomeSalvageable tissueTreatment modalitiesHoc AnalysisPerfusion timePatientsNatural historyOcclusionCollateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry
Anadani M, Finitsis S, Clarençon F, Richard S, Marnat G, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Blanc R, Lapergue B, Consoli A, Eugene F, Vannier S, Spelle L, Denier C, Boulanger M, Gauberti M, Liebeskind DS, de Havenon A, Saleme S, Macian F, Rosso C, Naggara O, Turc G, Ozkul-Wermester O, Papagiannaki C, Viguier A, Cognard C, Le Bras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, Maier B, Gory B. Collateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry. Journal Of NeuroInterventional Surgery 2021, 14: 551-557. PMID: 34140288, DOI: 10.1136/neurintsurg-2021-017553.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaCollateral CirculationEndovascular ProceduresHumansIschemic StrokeProspective StudiesRegistriesReperfusionStrokeThrombectomyTreatment OutcomeConceptsIschemic Stroke RegistryPoor collateral groupSuccessful reperfusionCollateral statusEndovascular therapyGood collateralsEVT outcomesStroke RegistryCollateral groupEndovascular treatmentFunctional outcomeFavorable outcomeHigher oddsTherapeutic Neuroradiology/SocietyInterventional Radiology guidelinesPoor collateralsPretreatment angiogramsClinical benefitExcellent outcomesRadiology guidelinesReperfusionLower oddsBetter outcomesSignificant interactionOutcomesBlood Pressure Management After Endovascular Therapy
Anadani M, de Havenon A, Mistry E, Anderson CS. Blood Pressure Management After Endovascular Therapy. Stroke 2021, 52: e263-e265. PMID: 34000832, PMCID: PMC8191365, DOI: 10.1161/strokeaha.121.034995.Peer-Reviewed Original ResearchEndovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, Siddiqui AH, Ribo M, de Havenon A, Fischer U, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Investigators T. Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 314-320. PMID: 33911016, DOI: 10.1136/neurintsurg-2020-017202.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresFibrinolytic AgentsHumansIschemic StrokeStrokeThrombectomyThrombolytic TherapyTreatment OutcomeConceptsCervical internal carotid arteryIntravenous thrombolysisAcute ischemic strokeTandem occlusionsEndovascular therapyInternal carotid arteryFavorable outcomeAcute strokeIschemic strokeCarotid arteryHigher oddsAnterior circulation tandem occlusionAcute tandem occlusionIschemic Stroke RegistrySignificant hemorrhagic complicationsIVT treatmentHemorrhagic complicationsStroke RegistrySuccessful reperfusionRankin ScaleConsecutive patientsIPTW analysisPrimary outcomeEndovascular treatmentPuncture timeDuration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke
de Havenon A, Alexander MD, Nogueira RG, Haussen DC, Castonguay AC, Linfante I, Johnson MA, Nguyen TN, Mokin M, Zaidat OO. Duration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke. Journal Of NeuroInterventional Surgery 2021, 13: 1128-1131. PMID: 33526478, PMCID: PMC8325713, DOI: 10.1136/neurintsurg-2020-016961.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresFemaleHumansMaleReperfusionRetrospective StudiesStentsStrokeThrombectomyTreatment OutcomeConceptsAcute ischemic stroke patientsIschemic stroke patientsSymptomatic strokeSuccessful reperfusionLogistic regression modelsAcute strokeEndovascular therapyStroke patientsLarge vessel occlusive strokeAnterior circulation occlusionCerebral Infarction scoreReal-world cohortLarge vessel occlusionBalloon guide catheterMiddle cerebral arteryIndividual patient dataInternal carotid arteryProbability of reperfusionLower ratesOcclusive strokeEndovascular thrombectomyMechanical thrombectomySecondary outcomesStroke onsetPrimary outcomeBlood Pressure Management Before, During, and After Endovascular Thrombectomy for Acute Ischemic Stroke
de Havenon A, Petersen N, Sultan-Qurraie A, Alexander M, Yaghi S, Park M, Grandhi R, Mistry E. Blood Pressure Management Before, During, and After Endovascular Thrombectomy for Acute Ischemic Stroke. Seminars In Neurology 2021, 41: 046-053. PMID: 33472269, PMCID: PMC8063274, DOI: 10.1055/s-0040-1722721.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureBrain IschemiaEndovascular ProceduresHumansIschemic StrokeStrokeThrombectomyTissue Plasminogen ActivatorTreatment OutcomeConceptsBlood pressure managementEndovascular thrombectomyBlood pressurePressure managementLarge vessel occlusion stroke patientsMaximum systolic blood pressureOptimal blood pressure managementAmerican Heart Association guidelinesAcute ischemic strokeHeart Association guidelinesSystolic blood pressurePenumbral perfusionSuccessful recanalizationIschemic strokeGuideline recommendationsStroke patientsHyperacute phaseAssociation guidelinesPatient outcomesClinical scenariosThrombectomyRecanalizationPatientsHgSpecific evidence
2020
Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study
de Havenon A, Narata AP, Amelot A, Saver JL, Bozorgchami H, Mattle HP, Ribo M, Andersson T, Zaidat OO, investigators A. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study. Journal Of NeuroInterventional Surgery 2020, 13: 779-783. PMID: 33219148, PMCID: PMC8134506, DOI: 10.1136/neurintsurg-2020-016427.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresHumansInfarction, Middle Cerebral ArteryMiddle Cerebral ArteryStrokeThrombectomyTreatment OutcomeConceptsMiddle cerebral artery occlusionM2 occlusionsCerebral artery occlusionM1 occlusionEndovascular thrombectomyAdverse eventsBetter outcomesArtery occlusionIschemic strokeReperfusion ratesM2-segment middle cerebral artery occlusionM2 middle cerebral artery occlusionsScale scoreHealth Stroke Scale scoreBaseline National InstitutesStroke Scale scoreAcute ischemic strokeMajor adverse eventsRankin Scale scorePaucity of dataLogistic regression modelsII trialSuccessful reperfusionII studyPrespecified analysisThe Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patientsPrediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 "
Taussky P, Agnoletto G, Grandhi R, Alexander MD, Wong KH, Albers GW, de Havenon A. Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 ". Journal Of NeuroInterventional Surgery 2020, 13: 805-808. PMID: 33077580, PMCID: PMC8093992, DOI: 10.1136/neurintsurg-2020-016548.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain IschemiaEndovascular ProceduresFemaleHumansMaleStrokeThrombectomyTreatment OutcomeConceptsEndovascular thrombectomyDEFUSE 3Statin usePrimary outcomeInclusion criteriaPredictive scoreHealth Stroke Scale scoreDEFUSE 3 studyEVT-treated patientsSecondary cohort analysisBaseline National InstitutesStroke Scale scoreHistory of diabetesPrediction of deathSelective inclusion criteriaUnivariate regression analysisHigh-risk categoryPotential predictive variablesEVT patientsPatient ageEndovascular therapyImaging evaluationPreprocedural variablesClinical trialsLethal outcomeEndovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes
de Havenon A, Yaghi S, Mistry EA, Delic A, Hohmann S, Shippey E, Stulberg E, Tirschwell D, Frontera JA, Petersen NH, Anadani M. Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes. Journal Of NeuroInterventional Surgery 2020, 12: 1045-1048. PMID: 32989032, PMCID: PMC7523171, DOI: 10.1136/neurintsurg-2020-016777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overBrain IschemiaComorbidityCoronavirus InfectionsCOVID-19Endovascular ProceduresEthnicityFemaleHospital MortalityHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesSex FactorsSocioeconomic FactorsStrokeStroke RehabilitationThrombectomyTreatment OutcomeYoung AdultConceptsCOVID-19 infectionAcute ischemic stroke patientsEndovascular thrombectomyIschemic stroke patientsHospital deathAIS patientsEVT patientsFavorable dischargeStroke patientsLower oddsCOVID-19Intensive care unit lengthLaboratory-confirmed COVID-19Vizient Clinical Data BaseComorbid COVID-19Acute coronary syndromeAcute renal failurePotential adverse eventsICD-10 codesMixed-effects logistic regressionClinical data baseCoronary syndromeLonger hospitalSystemic complicationsAdverse eventsBlood pressure reduction and outcome after endovascular therapy: a secondary analysis of the BEST study
Anadani M, de Havenon A, Yaghi S, Mehta T, Arora N, Starosciak AK, La Rosa F, Siegler J, Mistry AM, Chitale R, Spiotta AM, Tsivgoulis G, Khatri P, Mistry EA. Blood pressure reduction and outcome after endovascular therapy: a secondary analysis of the BEST study. Journal Of NeuroInterventional Surgery 2020, 13: 698-702. PMID: 32883780, PMCID: PMC8088286, DOI: 10.1136/neurintsurg-2020-016494.Peer-Reviewed Original ResearchConceptsSystolic blood pressure reductionSystolic blood pressureBlood pressure reductionEndovascular therapyPoor functional outcomeSuccessful recanalizationBlood pressurePoor outcomeFunctional outcomeOutcome groupAdmission systolic blood pressureOutcomes of EVTProspective observational cohort studyBaseline systolic blood pressureElevated systolic blood pressurePressure reductionHistory of hypertensionObservational cohort studyPoor outcome groupProspective multicenter cohortGood outcome groupAntihypertensive treatmentRevascularization statusCohort studyMulticenter cohort
2019
Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy
Mistry EA, Mehta T, Mistry A, Arora N, Starosciak AK, De Los Rios La Rosa F, Siegler JE, Chitale R, Anadani M, Yaghi S, Khatri P, de Havenon A. Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy. Stroke 2019, 51: 511-518. PMID: 31813361, PMCID: PMC8010595, DOI: 10.1161/strokeaha.119.027549.Peer-Reviewed Original ResearchConceptsHigh blood pressure variabilityBlood pressure variabilitySystolic blood pressure variabilityEndovascular treatmentPoor outcomeStroke patientsPressure variabilityAnterior circulation acute ischemic stroke patientsLower systolic blood pressure variabilityMeasure of BPVAcute ischemic stroke patientsDiastolic blood pressure variabilityLogistic regressionLarge vessel occlusion strokeMulticenter cohort studyIschemic stroke patientsWorse functional outcomeRate of deathNeurologic outcomeNeurological outcomeCohort studyEndovascular thrombectomyDiastolic BPHighest tertileOcclusion strokeBlood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study
Anadani M, Arthur AS, Alawieh A, Orabi Y, Alexandrov A, Goyal N, Psychogios MN, Maier I, Kim JT, Keyrouz SG, de Havenon A, Petersen NH, Pandhi A, Swisher CB, Inamullah O, Liman J, Kodali S, Giles JA, Allen M, Wolfe SQ, Tsivgoulis G, Cagle BA, Oravec CS, Gory B, De Marini P, Kan P, Rahman S, Richard S, Nascimento FA, Spiotta A. Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study. Journal Of NeuroInterventional Surgery 2019, 12: 932-936. PMID: 31806668, PMCID: PMC7998040, DOI: 10.1136/neurintsurg-2019-015561.Peer-Reviewed Original ResearchConceptsSBP reductionSystolic blood pressureSuccessful reperfusionMechanical thrombectomyPoor outcomeSafety outcomesAnterior circulation large vessel occlusionElevated systolic blood pressureModified Rankin Scale scoreBlood pressure reductionComprehensive stroke centerSymptomatic intracerebral hemorrhageAcute ischemic strokeMulticenter retrospective studyRankin Scale scoreLarge vessel occlusionIncomplete reperfusionReperfusion statusSafety endpointIschemic strokeStroke centersBlood pressureComplete reperfusionEndovascular therapyIntracerebral hemorrhageResults From DEFUSE 3
de Havenon A, Mlynash M, Kim-Tenser MA, Lansberg MG, Leslie-Mazwi T, Christensen S, McTaggart RA, Alexander M, Albers G, Broderick J, Marks MP, Heit JJ, Investigators O. Results From DEFUSE 3. Stroke 2019, 50: 632-638. PMID: 30726184, PMCID: PMC6628906, DOI: 10.1161/strokeaha.118.023407.Peer-Reviewed Original ResearchConceptsIschemic core volumeLarge vessel occlusionEndovascular thrombectomyCollateral statusTomography angiographyFunctional independenceDEFUSE 3Poor collateralsLeptomeningeal collateralsStroke patientsVessel occlusionGood collateralsAnterior circulation large vessel occlusionBaseline ischemic core volumeSmall ischemic core volumeAcute ischemic stroke patientsDEFUSE 3 patientsIschemic stroke patientsModified Rankin ScaleStroke-related deathComputed tomography angiographyGood leptomeningeal collateralsTreatment effectsNeurological outcomePrespecified analysisSEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke
Sultan-Qurraie A, Witt T, de Havenon A, Ribo M, Zaidat OO. SEIMLESS: Simultaneous Extracranial, Intracranial Management of (tandem) LESsions in Stroke. Journal Of NeuroInterventional Surgery 2019, 11: 879. PMID: 30674634, DOI: 10.1136/neurintsurg-2018-014403.Peer-Reviewed Original ResearchConceptsTandem lesionsAcute ischemic stroke patientsCerebral Infarction scoreDistal intracranial occlusionsPost-procedural ThrombolysisIschemic stroke patientsIntracranial arterial occlusionTotal fluoroscopy timeCase-control studyAmount of contrastIntracranial recanalizationEndovascular thrombectomyRecanalization timeArterial punctureIntracranial occlusionArterial occlusionStroke patientsStroke trialsArterial accessConcomitant occlusionDistal lesionsFluoroscopy timeClinical dataProximal vesselsPatients