2021
White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial
Sheibani N, Wong KH, Turan TN, Yeatts SD, Gottesman RF, Prabhakaran S, Rost NS, de Havenon A. White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 105764. PMID: 33823461, PMCID: PMC8107132, DOI: 10.1016/j.jstrokecerebrovasdis.2021.105764.Peer-Reviewed Original ResearchConceptsSystolic Blood Pressure Intervention TrialWhite matter hyperintensity volumeSystolic blood pressurePrimary outcomeHazard ratioLog-transformed white matter hyperintensity volumeGoal systolic blood pressureLog-transformed continuous variableComposite of strokeIntensive BP loweringHigh cardiovascular riskAcute coronary syndromeCongestive heart failureProspective clinical trialsCardiovascular disease outcomesFuture CVD riskWhite matter hyperintensitiesSubset of participantsBP loweringCardiovascular deathCardiovascular eventsCoronary syndromeCardiovascular riskCVD riskBlood pressure
2019
Is There Equipoise Regarding the Optimal Medical Treatment of Patients with Asymptomatic White Matter Hyperintensities?
de Havenon A, Prabhakaran S, Turan T, Gottesman R, Yeatts S, Rost N. Is There Equipoise Regarding the Optimal Medical Treatment of Patients with Asymptomatic White Matter Hyperintensities? Journal Of Stroke And Cerebrovascular Diseases 2019, 28: 104371. PMID: 31495669, PMCID: PMC8015436, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104371.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsAsymptomatic DiseasesAttitude of Health PersonnelDisease ProgressionHealth Care SurveysHealth Knowledge, Attitudes, PracticeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLeukoencephalopathiesNeurologistsPlatelet Aggregation InhibitorsPractice Patterns, Physicians'Therapeutic EquipoiseTreatment OutcomeConceptsAsymptomatic white matter hyperintensitiesWhite matter hyperintensitiesOptimal medical treatmentMatter hyperintensitiesMedical treatmentCognitive impairmentIntensive Blood Pressure ReductionNeurologists' attitudesBlood pressure targetsStroke prevention therapyBlood pressure reductionOptimal medical managementRegional coordinating centersMild cognitive impairmentStatin therapyIschemic strokeMicrovascular diseasePressure targetsPrevention therapyClinical outcomesFunctional disabilityMedical managementPatient populationCommon manifestationWMH progression