2023
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study
Prasad A, Gilmore E, Kim J, Begunova L, Olexa M, Beekman R, Falcone G, Matouk C, Ortega-Gutierrez S, Temkin N, Barber J, Diaz-Arrastia R, de Havenon A, Petersen N. Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Neurocritical Care 2023, 1-9. PMID: 38158481, PMCID: PMC11285118, DOI: 10.1007/s12028-023-01896-x.Peer-Reviewed Original ResearchCerebral perfusion pressureBrain tissue hypoxiaSevere traumatic brain injuryTissue hypoxiaTraumatic brain injuryBlood pressureCerebral hypoperfusionBrain injuryAutoregulatory functionMean cerebral perfusion pressureSecondary analysisOptimal cerebral perfusion pressurePercent timeCerebral autoregulatory functionLimits of autoregulationPhase II trialArterial blood pressureBrain tissue oxygenIntracranial pressure monitoringCPP augmentationHemodynamic augmentationAutoregulatory indexII trialBP managementPerfusion pressureModelling anticoagulation and health-related quality of life in those with atrial fibrillation: a secondary analysis of AFFIRM
Stulberg E, Delic A, Zheutlin A, Steinberg B, Yaghi S, Sharma R, de Havenon A. Modelling anticoagulation and health-related quality of life in those with atrial fibrillation: a secondary analysis of AFFIRM. Clinical Research In Cardiology 2023, 113: 1200-1210. PMID: 37962572, DOI: 10.1007/s00392-023-02335-9.Peer-Reviewed Original ResearchHealth-related qualityTime-varying confoundingAtrial fibrillationTime-varying covariatesSecondary analysisSelection biasAssociation of anticoagulationAssociation of warfarinAtrial Fibrillation FollowAge-stratified analysisLife substudyWarfarin useBetter HRQoLPrimary endpointTrial qualityHigher HRQoLStudy baselineEffect modificationStratified analysisAnticoagulationHRQoLInverse probabilityFibrillationStudy periodTime pointsUnderstanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data
de Havenon A, Bangad A, Skolarus L, Aldridge C, Braun R, Cole J, Cramer S, Lindgren A, Sunmonu N, Worrall B, Lohse K. Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data. Stroke 2023, 54: e201-e202. PMID: 36896708, PMCID: PMC10133020, DOI: 10.1161/strokeaha.122.042168.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke trialsIschemic stroke trialsStroke trialsSecondary analysisFollowTrials
2022
Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial
Lang A, de Havenon A, Mac Grory B, Henninger N, Shu L, Furie K, Easton J, Kim A, Johnston S, Yaghi S. Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial. European Stroke Journal 2022, 8: 328-333. PMID: 37021190, PMCID: PMC10069178, DOI: 10.1177/23969873221148224.Peer-Reviewed Original ResearchConceptsSubsequent ischemic strokeEffect of clopidogrelSubsequent stroke riskIschemic strokeMajor hemorrhagePoint trialStroke riskSmoking statusMinor Ischemic Stroke (POINT) trialSubgroup interaction analysesMultivariable Cox regressionMinor ischemic strokeIschemic stroke trialsEffect of smokingNon-significant trendNew TIACurrent smokersStroke trialsTobacco smokingCox regressionIndex eventSmokersSecondary analysisClopidogrelStrokePredictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis
Shu L, Bakradze E, Omran SS, Giles J, Amar J, Henninger N, Elnazeir M, Liberman A, Moncrieffe K, Rotblat J, Sharma R, Cheng Y, Zubair AS, Simpkins A, Li G, Kung J, Perez D, Heldner MR, Scutelnic A, von Martial R, Siepen B, Rothstein A, Khazaal O, Do D, Al Kasab S, Rahman LA, Mistry EA, Kerrigan D, Lafever H, Nguyen TN, Klein P, Aparicio HJ, Frontera JA, Kuohn L, Agarwal S, Stretz C, Kala N, ElJamal S, Chang A, Cutting S, Indraswari F, de Havenon A, Muddasani V, Wu T, Wilson D, Nouh A, Asad D, Qureshi A, Moore J, Khatri P, Aziz Y, Casteigne B, Khan M, Cheng Y, Grory BM, Weiss M, Ryan D, Vedovati MC, Paciaroni M, Siegler J, Kamen S, Yu S, Guerrero CL, Atallah E, De Marchis GM, Brehm A, Dittrich T, Psychogios M, Alvarado-Dyer R, Kass-Hout T, Prabhakaran S, Honda T, Liebeskind D, Furie K, Yaghi S. Predictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis. Neurology 2022, 99: e2368-e2377. PMID: 36123126, PMCID: PMC9687409, DOI: 10.1212/wnl.0000000000201122.Peer-Reviewed Original ResearchConceptsCerebral venous thrombosisRecurrent venous thrombosisHistory of VTEVenous thrombosisVenous thromboembolismAntiphospholipid antibodiesBlack raceDiagnosis of CVTPositive antiphospholipid antibodiesRecurrent venous thrombosesAntiphospholipid antibody syndromeRecurrent venous thromboembolismCox regression analysisRisk of recurrenceMulticenter international studyAntibody syndromeOral anticoagulationVenous thrombosesConsecutive patientsRare causeMean ageTreatment strategiesThrombosisPatientsSecondary analysisCerebral Autoregulatory Function Before, During, and After Therapeutic Interventions Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study (S21.001)
Prasad A, Kobsa J, Soto A, Bartolome D, Begunova L, Kim J, Gilmore E, Sheth K, Matouk C, De Havenon A, Diaz-Arrastia R, Petersen N. Cerebral Autoregulatory Function Before, During, and After Therapeutic Interventions Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study (S21.001). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.557.Peer-Reviewed Original Research
2021
Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study
Yaghi S, Mistry E, de Havenon A, Guerrero C, Nouh A, Liberman AL, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Grory B, Fakhri H, Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini‐Naghani I, Siddu M, Scher E, Trivedi T, Wu T, Khan M, Keyrouz S, Furie K, Henninger N. Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study. Journal Of The American Heart Association 2021, 10: e020945. PMID: 34323120, PMCID: PMC8475683, DOI: 10.1161/jaha.121.020945.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeMechanical thrombectomyAlteplase useIschemic strokeHemorrhagic transformationAtrial fibrillationPrimary analysisEfficacy of alteplaseInitiation of anticoagulationComprehensive stroke centerBinary logistic regressionIntravenous alteplaseStroke centersConsecutive patientsStroke StudyAlteplaseMortality ratePatientsSecondary analysisMortalityStrokeLogistic regressionFurther studiesFibrillationIAC studyUsing Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Baradaran H, Delic A, Wong KH, Sheibani N, Alexander M, McNally JS, Majersik JJ, De Havenon A. Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis. Cerebrovascular Diseases Extra 2021, 11: 37-43. PMID: 33601394, PMCID: PMC7989729, DOI: 10.1159/000514373.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersCarotid Intima-Media ThicknessCarotid StenosisFemaleHumansInflammation MediatorsInterleukin-6Ischemic StrokeMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsUltrasonography, DopplerUnited StatesVascular StiffnessConceptsIschemic strokeCarotid distensibilityCarotid stenosisMulti-Ethnic StudyInterleukin-6Primary outcomeRisk factorsInflammation measurementsClinical trial inclusion criteriaSecondary analysisPrimary ischemic strokeIncident ischemic strokeTrial inclusion criteriaVascular risk factorsSystolic blood pressureTraditional risk factorsBaseline study visitCox regression modelIschemic stroke riskStroke risk predictionPrimary prevention effortsUltrasound-derived measurementsIncident strokeMean followPatient age
2020
Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage
Menacho ST, Grandhi R, Delic A, Anadani M, Ziai WC, Awad IA, Hanley DF, de Havenon A. Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105540. PMID: 33360250, PMCID: PMC8080544, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105540.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Trials, Phase III as TopicDatabases, FactualFemaleHumansIntracranial HemorrhagesIntracranial PressureMaleMiddle AgedMonitoring, PhysiologicPredictive Value of TestsRandomized Controlled Trials as TopicRecovery of FunctionRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsICP monitor placementNontraumatic intracranial hemorrhageIntracranial hemorrhageIntracranial pressure monitorPoor outcomeNeurologic outcomePressure monitorPropensity score-matched cohortMonitor placementIdentification of patientsSpontaneous intracranial hemorrhageExternal ventricular drainInvasive ICP monitoringLogistic regression modelsIntraparenchymal monitorsIII trialsSecondary outcomesPrimary outcomeBalanced cohortVentricular drainICP monitorICP monitoringPatientsSecondary analysisGreater riskApolipoproteins, Lipoprotein(a) and Risk of Intracranial Atherosclerosis and Ischemic Stroke: A Secondary Analysis of the ARIC Study (1067)
de Havenon A, Majersik J, Sheibani N, Wong K. Apolipoproteins, Lipoprotein(a) and Risk of Intracranial Atherosclerosis and Ischemic Stroke: A Secondary Analysis of the ARIC Study (1067). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1067.Peer-Reviewed Original ResearchQuality of Life for Younger Versus Older Patients Following Endovascular Thrombectomy in the Extended Window: A Secondary Analysis of DEFUSE 3 (1397)
de Havenon A, Majersik J, Terrill A, Taylor K, Albers G. Quality of Life for Younger Versus Older Patients Following Endovascular Thrombectomy in the Extended Window: A Secondary Analysis of DEFUSE 3 (1397). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1397.Peer-Reviewed Original Research
2019
End-of-Treatment Intracerebral and Ventricular Hemorrhage Volume Predicts Outcome
de Havenon A, Joyce E, Yaghi S, Ansari S, Delic A, Taussky P, Alexander M, Tirschwell D, Grandhi R. End-of-Treatment Intracerebral and Ventricular Hemorrhage Volume Predicts Outcome. Stroke 2019, 51: 652-654. PMID: 31842688, PMCID: PMC7000178, DOI: 10.1161/strokeaha.119.028199.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhage volumeIntracerebral hemorrhageClot evacuationHemorrhage volumeBetter outcomesVolume scoreInvasive clot evacuationMISTIE III trialSurgical clot evacuationGood neurological outcomePotential clinical benefitNeurological outcomeIII trialsPrimary outcomeClinical benefitHematoma volumePoor outcomeFunctional outcomeSurgical armICH sizeTherapeutic planningSecondary analysisPatientsStrong associationStratification scaleCarotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study
de Havenon A, Wong K, Elkhetali A, McNally JS, Majersik JJ, Rost NS. Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study. American Journal Of Neuroradiology 2019, 40: 1369-1373. PMID: 31248859, PMCID: PMC7048485, DOI: 10.3174/ajnr.a6115.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensity volumeCarotid artery stiffnessTotal brain volumePressure-strain elastic modulusArtery stiffnessHyperintensity volumeBrain volumeAtherosclerosis RiskArterial stiffnessMR imagingCommunity studyStiffness indexHigher white matter hyperintensity volumeLower total brain volumeSecondary analysisCommon carotid artery stiffnessSmall artery diseaseMultivariable linear regression modelsCerebrovascular diseaseDementia riskSonography measurementsMultivariate modelCarotid strainPotential mechanismsPatients
2018
Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage
de Havenon A, Majersik JJ, Stoddard G, Wong KH, McNally JS, Smith AG, Rost NS, Tirschwell DL. Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage. Stroke 2018, 49: 1981-1984. PMID: 30012822, PMCID: PMC6202185, DOI: 10.1161/strokeaha.118.022133.Peer-Reviewed Original ResearchConceptsBlood pressure variabilitySystolic blood pressure variabilitySystolic blood pressureNeurological outcomeRankin ScaleBlood pressureAcute periodIntracerebral hemorrhageWorse outcomesPressure variabilityLong-term neurological outcomeUtility-weighted modified Rankin scaleWorse neurological outcomeAcute ischemic strokeModified Rankin ScaleBlood pressure meansATACH-2 trialProtocol-based approachATACH-2Ischemic strokeSecondary outcomesPrimary outcomeEarly identificationSecondary analysisConsistent association