2024
Impact of Procedure Time on First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke
Koo A, Reeves B, Renedo D, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Arthur A, Yoshimura S, Cuellar H, Grossberg J, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Park M, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, Spiotta A, Sheth K, de Havenon A, Matouk C. Impact of Procedure Time on First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke. Neurosurgery 2024, 95: 128-136. PMID: 38483158, DOI: 10.1227/neu.0000000000002900.Peer-Reviewed Original ResearchAnterior circulation large vessel occlusion acute ischemic strokeAcute ischemic strokeLarge vessel occlusion acute ischemic strokeProcedure timeMechanical thrombectomyExcellent reperfusionClinical benefitIschemic strokeAnterior circulation acute ischemic strokeSuccess of mechanical thrombectomyModified Rankin Scale scoreRankin Scale scoreLogistic regression modelsNo significant differencePrimary study exposuresPrimary outcomeFunctional outcomesPotential confoundersStudy exposureThrombectomy devicesScale scoreThrombectomyReperfusionPatientsSignificant difference
2023
Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Sujijantarat N, Koo A, Jambor I, Malhotra A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Lalwani D, Zabinska J, Roy J, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Gilmore E, Sansing L, de Havenon A, Olexa M, Schiff S, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.000921.Peer-Reviewed Original ResearchMechanical thrombectomyInterventional radiology suiteMagnetic resonance imagingRadiology suiteConventional MRIResonance imagingCerebral Infarction scoreOngoing brain injuryLarge vessel occlusionInfarct burdenRevascularization timeInfarct volumeClinical characteristicsInfarct progressionAdverse eventsIschemic changesMethods PatientsMedian timeBedside evaluationBrain injuryTimely imagingResults TwentyPatientsSubsequent imagingProcedural detailsEndovascular Therapy for Acute Stroke: New Evidence and Indications
Sahoo A, Abdalkader M, Yamagami H, Huo X, Sun D, Jia B, Weyland C, Diana F, Kaliaev A, Klein P, Bui J, Kasab S, de Havenon A, Zaidat O, Zi W, Yang Q, Michel P, Siegler J, Yaghi S, Hu W, Nguyen T. Endovascular Therapy for Acute Stroke: New Evidence and Indications. Journal Of Neuroendovascular Therapy 2023, 17: 232-242. PMID: 38025253, PMCID: PMC10657733, DOI: 10.5797/jnet.ra.2023-0047.Peer-Reviewed Original ResearchRandomized clinical trialsTreatment of patientsIntravenous thrombolysisEndovascular therapyMechanical thrombectomyClinical trialsAcute ischemic strokeDistal vessel occlusionNon-contrast CTExtended windowOngoing studiesCTA collateralsRescue stentingTandem occlusionsAcute strokeCore infarctIschemic strokeTreatment indicationsCore infarctionVessel occlusionRecent trialsThrombectomyPatientsAdvanced imagingNarrative review
2022
Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee
Nguyen T, Castonguay A, Siegler J, Nagel S, Lansberg M, de Havenon A, Sheth S, Abdalkader M, Tsai J, Albers G, Masoud H, Jovin T, Martins S, Nogueira R, Zaidat O, Committee F. Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee. Stroke Vascular And Interventional Neurology 2022, 3 PMID: 39380893, PMCID: PMC11460660, DOI: 10.1161/svin.122.000512.Peer-Reviewed Original ResearchSociety of VascularLarge vessel occlusion strokeLarge vessel occlusionNeurology guidelinesExtended time windowOcclusion strokeEndovascular therapyVessel occlusionAnterior circulation large vessel occlusion strokeClinical-imaging mismatchDEFUSE 3 studyComputed tomography perfusionRecent clinical trialsTreatment of patientsNew treatment paradigmSole imaging modalityMagnetic resonance imagingWriting groupMechanical thrombectomyEndovascular treatmentPatient selectionInfarct sizeLate presentationTomography perfusionTreatment paradigmRescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis
Almallouhi E, Murad M, Chalhoub R, Kicielinski K, Lena J, Brennan E, Zaidat O, de Havenon A, Spiotta A, Al Kasab S. Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2022, 3 DOI: 10.1161/svin.122.000510.Peer-Reviewed Original ResearchLarge vessel occlusionEmbolic large-vessel occlusionRescue therapyICAS-LVOOutcomes of patientsVessel occlusionIntracranial atherosclerosisRescue treatmentOdds ratioSystematic reviewEmergent large vessel occlusionRescue endovascular treatmentRandom-effects modelAcute strokeBackground PatientsSuccessful recanalizationMechanical thrombectomyEndovascular treatmentBetter outcomesPatientsMeta-AnalysisCINAHL CompleteCombination of treatmentsOcclusionDatabase date2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee
Masoud H, de Havenon A, Castonguay A, Asif K, Nguyen T, Mehta B, Abdalkader M, Gutierrez S, Leslie‐Mazwi T, Mansour O, Ma A, Czap A, Kenmuir C, Sheth S, Novakovic‐White R, Nour M, Jadhav A, Janardhan V, Hassan A, Liebeskind D, Malik A, Zaidat O. 2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000276.Peer-Reviewed Original ResearchSociety of VascularAcute ischemic strokeLarge vessel occlusionIntravenous thrombolysisNeurology guidelinesPractice UpdateIschemic strokeMechanical thrombectomyVessel occlusionClinical trialsLarge vessel occlusion acute ischemic strokeEmergent large vessel occlusionIschemic stroke patientsRecent clinical trialsClass of recommendationRecent clinical dataClinical trial resultsLevel of evidenceClinical trial dataClinical decision makingStroke patientsCombination therapyClinical dataThrombolysisCurrent evidence
2021
Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study
Yaghi S, Mistry E, de Havenon A, Guerrero C, Nouh A, Liberman AL, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini‐Naghani I, Siddu M, Scher E, Trivedi T, Wu T, Khan M, Keyrouz S, Furie K, Henninger N. Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study. Journal Of The American Heart Association 2021, 10: e020945. PMID: 34323120, PMCID: PMC8475683, DOI: 10.1161/jaha.121.020945.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeMechanical thrombectomyAlteplase useIschemic strokeHemorrhagic transformationAtrial fibrillationPrimary analysisEfficacy of alteplaseInitiation of anticoagulationComprehensive stroke centerBinary logistic regressionIntravenous alteplaseStroke centersConsecutive patientsStroke StudyAlteplaseMortality ratePatientsSecondary analysisMortalityStrokeLogistic regressionFurther studiesFibrillationIAC studyMagnitude of blood pressure change and clinical outcomes after thrombectomy in stroke caused by large artery occlusion
Anadani M, Matusevicius M, Tsivgoulis G, Peeters A, Nunes A, Mancuso M, Roffe C, de Havenon A, Ahmed N. Magnitude of blood pressure change and clinical outcomes after thrombectomy in stroke caused by large artery occlusion. European Journal Of Neurology 2021, 28: 1922-1930. PMID: 33682232, DOI: 10.1111/ene.14807.Peer-Reviewed Original ResearchConceptsSystolic blood pressureAssociated with unfavorable outcomesRestricted cubic spline modelsUnfavorable outcomeLow systolic blood pressureRestricted cubic splinesCubic spline modelsLogistic regression modelsMixed logistic regression modelsArtery occlusion strokeMultivariable mixed logistic regression modelsMechanical thrombectomyAssociated with poor functional outcomeSBP increaseAdmission systolic blood pressureHigher SBPPoor functional outcomeMagnitude of blood pressure changesPredictors of unfavorable outcomeIncreased risk of unfavorable outcomeOcclusion strokePrimary outcomeSBP changeRisk of unfavorable outcomeStudy populationDuration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke
de Havenon A, Alexander MD, Nogueira RG, Haussen DC, Castonguay AC, Linfante I, Johnson MA, Nguyen TN, Mokin M, Zaidat OO. Duration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke. Journal Of NeuroInterventional Surgery 2021, 13: 1128-1131. PMID: 33526478, PMCID: PMC8325713, DOI: 10.1136/neurintsurg-2020-016961.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke patientsIschemic stroke patientsSymptomatic strokeSuccessful reperfusionLogistic regression modelsAcute strokeEndovascular therapyStroke patientsLarge vessel occlusive strokeAnterior circulation occlusionCerebral Infarction scoreReal-world cohortLarge vessel occlusionBalloon guide catheterMiddle cerebral arteryIndividual patient dataInternal carotid arteryProbability of reperfusionLower ratesOcclusive strokeEndovascular thrombectomyMechanical thrombectomySecondary outcomesStroke onsetPrimary outcome
2020
Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States
de Havenon A, Ney JP, Callaghan B, Delic A, Hohmann S, Shippey E, Esper GJ, Stulberg E, Tirschwell D, Frontera J, Yaghi S, Anadani M, Majersik JJ. Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105535. PMID: 33310595, PMCID: PMC7832426, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105535.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsIschemic strokeFavorable dischargeStroke patientsPrimary analysisLaboratory-confirmed COVID-19COVID-19Vizient Clinical Data BaseAcute coronary syndromeAcute renal failureCohort of patientsCoronavirus disease 2019Clinical data baseCoronary syndromeHospital deathVenous thromboembolismMechanical thrombectomyRenal failureHispanic patientsDischarge diagnosisSubarachnoid hemorrhageWorse outcomesDisease 2019High riskLower oddsAcute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic
Agarwal S, Scher E, Rossan-Raghunath N, Marolia D, Butnar M, Torres J, Zhang C, Kim S, Sanger M, Humbert K, Tanweer O, Shapiro M, Raz E, Nossek E, Nelson PK, Riina HA, de Havenon A, Wachs M, Farkas J, Tiwari A, Arcot K, Parella DT, Liff J, Wu T, Wittman I, Caldwell R, Frontera J, Lord A, Ishida K, Yaghi S. Acute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105068. PMID: 32807471, PMCID: PMC7305900, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusComprehensive Health CareCoronavirus InfectionsCOVID-19Critical PathwaysDelivery of Health Care, IntegratedFemaleHumansMaleMiddle AgedNew York CityPandemicsPatient Care TeamPneumonia, ViralQuality ImprovementQuality Indicators, Health CareRegistriesRetrospective StudiesSARS-CoV-2StrokeThrombectomyThrombolytic TherapyTime FactorsTime-to-TreatmentTreatment OutcomeWorkflowConceptsComprehensive stroke centerAcute ischemic strokePre-pandemic groupAIS patientsStroke centersTransient ischemic attack/strokeAcute stroke processDefect-free careLonger median doorEmergency health care servicesAcute stroke careConsecutive AIS patientsQuality improvement registrySuccessful recanalization rateLong-term outcomesQuality of careHealth care servicesCOVID-19 screeningAcute strokeIschemic strokeLonger doorMechanical thrombectomyMedian doorStroke severityDischarge outcomes
2019
Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study
Anadani M, Arthur AS, Alawieh A, Orabi Y, Alexandrov A, Goyal N, Psychogios MN, Maier I, Kim JT, Keyrouz SG, de Havenon A, Petersen NH, Pandhi A, Swisher CB, Inamullah O, Liman J, Kodali S, Giles JA, Allen M, Wolfe SQ, Tsivgoulis G, Cagle BA, Oravec CS, Gory B, De Marini P, Kan P, Rahman S, Richard S, Nascimento FA, Spiotta A. Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study. Journal Of NeuroInterventional Surgery 2019, 12: 932-936. PMID: 31806668, PMCID: PMC7998040, DOI: 10.1136/neurintsurg-2019-015561.Peer-Reviewed Original ResearchConceptsSBP reductionSystolic blood pressureSuccessful reperfusionMechanical thrombectomyPoor outcomeSafety outcomesAnterior circulation large vessel occlusionElevated systolic blood pressureModified Rankin Scale scoreBlood pressure reductionComprehensive stroke centerSymptomatic intracerebral hemorrhageAcute ischemic strokeMulticenter retrospective studyRankin Scale scoreLarge vessel occlusionIncomplete reperfusionReperfusion statusSafety endpointIschemic strokeStroke centersBlood pressureComplete reperfusionEndovascular therapyIntracerebral hemorrhageDiurnal Variations in the First 24/7 Mobile Stroke Unit
Zaidat OO, Changal KH, Sultan-Qurraie A, de Havenon A, Calderon VJ, Goins-Whitmore J, Patterson MS, Lin E. Diurnal Variations in the First 24/7 Mobile Stroke Unit. Stroke 2019, 50: 1911-1914. PMID: 31104620, DOI: 10.1161/strokeaha.119.024950.Peer-Reviewed Original ResearchConceptsStroke unitResults One hundred ninetyEvening shiftsMorning shiftPrehospital stroke careMobile stroke unitMSU patientsProspective databaseIntravenous thrombolyticsMechanical thrombectomyPatient characteristicsStroke treatmentStroke careTreatment metricsTherapeutic interventionsNocturnal shiftPatients