2024
Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States
de Havenon A, Zhou L, Koo A, Matouk C, Falcone G, Sharma R, Ney J, Shu L, Yaghi S, Kamel H, Sheth K. Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States. JAMA Neurology 2024, 81: 264-272. PMID: 38285452, PMCID: PMC10825786, DOI: 10.1001/jamaneurol.2023.5416.Peer-Reviewed Original ResearchNational Institutes of Health Stroke ScaleNational Institutes of Health Stroke Scale scoreOdds of discharge homeDischarged homeIschemic strokeRate of endovascular thrombectomyMultivariate logistic regressionNational Inpatient Sample databaseHealth Stroke ScaleIntervention patientsInpatient Sample databaseMain OutcomesIntervention statusHospitalization of patientsPotential confoundersUS hospitalsEndovascular thrombectomyStroke patientsCohort studySecondary outcomesLogistic regressionCardiac interventionsStroke severityStroke ScaleGroup of hospitalized patients
2023
Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors
Acosta J, Both C, Demarais Z, Conlon C, Leasure A, Torres-Lopez V, de Havenon A, Petersen N, Gill T, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Neurology 2023, 100: e1587-e1597. PMID: 36690452, PMCID: PMC10103110, DOI: 10.1212/wnl.0000000000206763.Peer-Reviewed Original ResearchConceptsWorse BP controlUncontrolled blood pressureDiastolic blood pressureBlood pressureStroke survivorsPolygenic risk scoresBP controlPolygenic susceptibilityMean diastolic blood pressureMean systolic blood pressureStroke Prevention TrialBlood pressure controlSystolic blood pressureResistant hypertensionVascular eventsHemorrhagic strokePrevention trialsVitamin InterventionMultivariable modelRisk scoreGenetic predispositionPressure controlLogistic regressionSurvivorsHypertension
2021
Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study
Yaghi S, Mistry E, de Havenon A, Guerrero C, Nouh A, Liberman AL, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Grory B, Fakhri H, Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini‐Naghani I, Siddu M, Scher E, Trivedi T, Wu T, Khan M, Keyrouz S, Furie K, Henninger N. Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study. Journal Of The American Heart Association 2021, 10: e020945. PMID: 34323120, PMCID: PMC8475683, DOI: 10.1161/jaha.121.020945.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeMechanical thrombectomyAlteplase useIschemic strokeHemorrhagic transformationAtrial fibrillationPrimary analysisEfficacy of alteplaseInitiation of anticoagulationComprehensive stroke centerBinary logistic regressionIntravenous alteplaseStroke centersConsecutive patientsStroke StudyAlteplaseMortality ratePatientsSecondary analysisMortalityStrokeLogistic regressionFurther studiesFibrillationIAC studyPredicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change
Mistry EA, Yeatts S, de Havenon A, Mehta T, Arora N, La Rosa F, Starosciak AK, Siegler JE, Mistry AM, Yaghi S, Khatri P. Predicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change. Stroke 2021, 52: 2547-2553. PMID: 34000830, PMCID: PMC11261999, DOI: 10.1161/strokeaha.120.032487.Peer-Reviewed Original ResearchConceptsNIHSS scoreLong-term functional outcomeNIHSS score changeComprehensive stroke centerHealth Stroke ScaleProspective observational studyEarly time pointsStroke centersStroke ScaleEndovascular therapyMRS outcomesMRS scoreRankin ScaleStroke patientsFunctional outcomeSurrogate markerClinical studiesNIHSSMultivariable modelingObservational studyOutcome measuresPatientsPercent changeScore changeLogistic regression
2019
Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy
Mistry EA, Mehta T, Mistry A, Arora N, Starosciak AK, De Los Rios La Rosa F, Siegler JE, Chitale R, Anadani M, Yaghi S, Khatri P, de Havenon A. Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy. Stroke 2019, 51: 511-518. PMID: 31813361, PMCID: PMC8010595, DOI: 10.1161/strokeaha.119.027549.Peer-Reviewed Original ResearchConceptsHigh blood pressure variabilityBlood pressure variabilitySystolic blood pressure variabilityEndovascular treatmentPoor outcomeStroke patientsPressure variabilityAnterior circulation acute ischemic stroke patientsLower systolic blood pressure variabilityMeasure of BPVAcute ischemic stroke patientsDiastolic blood pressure variabilityLogistic regressionLarge vessel occlusion strokeMulticenter cohort studyIschemic stroke patientsWorse functional outcomeRate of deathNeurologic outcomeNeurological outcomeCohort studyEndovascular thrombectomyDiastolic BPHighest tertileOcclusion stroke