2024
Use of a dedicated open transcarotid access system for neurovascular disease
Sujijantarat N, Renedo D, Antonios J, Koo A, Amllay A, Nowicki K, Cord B, Hebert R, de Havenon A, Sheth K, Petersen N, Matouk C. Use of a dedicated open transcarotid access system for neurovascular disease. Journal Of NeuroInterventional Surgery 2024, jnis-2024-021599. PMID: 38719442, DOI: 10.1136/jnis-2024-021599.Peer-Reviewed Original ResearchExtracranial carotid stenosisTranscarotid artery revascularizationNeurovascular diseasesCarotid stenosisDatabase of consecutive patientsNeurovascular pathologyTreatment of neurovascular diseasesAccess-related complicationsTreatment of neurovascular pathologiesOff-label useCarotid flow reversalConsecutive patientsRetrospective reviewIntracranial atherosclerotic diseasePeriprocedural complicationsEndovascular treatmentArtery revascularizationProcedural characteristicsArterial sheathCarotid diseaseAcademic centersIntracranial aneurysmsPatientsTranscarotid approachTransradial approach
2023
Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes
de Havenon A, Zaidat O, Amin-Hanjani S, Nguyen T, Bangad A, Abbasi M, Anadani M, Almallouhi E, Chatterjee R, Mazighi M, Mistry E, Yaghi S, Derdeyn C, Hong K, Kvernland A, Leslie-Mazwi T, Al Kasab S. Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes. Stroke 2023, 54: 1695-1705. PMID: 36938708, PMCID: PMC10202848, DOI: 10.1161/strokeaha.122.040008.Peer-Reviewed Original ResearchConceptsLarge vessel occlusion strokeIntracranial atherosclerotic diseaseEndovascular thrombectomyAtherosclerotic diseaseOcclusion strokeFunctional outcome benefitsVascular risk factorsAdjunctive medicationsMedical managementPatient factorsInterventional treatmentOutcome benefitsRisk factorsObservational studyEarly identificationTreatment planningThrombectomyUnique considerationsPatientsStrokeLVODiseaseRevascularizationMedicationsReview
2021
Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease
Liebeskind DS, Hinman JD, Kaneko N, Kitajima H, Honda T, De Havenon AH, Feldmann E, Nogueira RG, Prabhakaran S, Romano JG, Callas PW, Schneider DJ. Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease. Frontiers In Neurology 2021, 12: 646309. PMID: 33716947, PMCID: PMC7947292, DOI: 10.3389/fneur.2021.646309.Peer-Reviewed Original ResearchIntracranial atherosclerotic diseaseEndothelial shear stressFcγRIIa expressionAtherosclerotic diseaseFcγRIIA receptorsArterial stenosisAnti-platelet medicationAnti-platelet strategiesPotent risk factorLocal pathophysiologyRecurrent strokeRisk factorsCardiovascular diseaseVascular remodelingIndividual patientsPlaque growthPlatelet activationElevated expressionDiseasePlatelet interactionClinical realmRecurrent eventsStenosisDifferential activationLuminal wall
2020
Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke
de Havenon A, Khatri P, Prabhakaran S, Yeatts S, Peterson C, Sacchetti D, Alexander M, Cutting S, Mac Grory B, Furie K, Liebeskind D, Yaghi S. Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke. Journal Of Neuroimaging 2020, 30: 468-470. PMID: 32579278, PMCID: PMC8010594, DOI: 10.1111/jon.12710.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseSymptomatic intracranial atherosclerotic diseaseDistal hypoperfusionRecurrent strokeComputed tomographyRetrospective study of patientsImpaired distal flowIntracranial atherosclerotic disease patientsSymptomatic ischemic strokeStudy of patientsAssociated with recurrent strokeMiddle cerebral arteryAssociated with stroke recurrenceIntracranial carotidSecondary stroke preventionRetrospective studySymptomatic arteryPerfusion statusHazard ratioPrimary outcomeCerebral arteryStroke preventionHypoperfusionPatientsInclusion criteria
2019
Letter by Kvernland et al Regarding Article, “Stroke Mechanisms in Symptomatic Intracranial Atherosclerotic Disease: Classification and Clinical Implications”
Kvernland A, Yaghi S, de Havenon A. Letter by Kvernland et al Regarding Article, “Stroke Mechanisms in Symptomatic Intracranial Atherosclerotic Disease: Classification and Clinical Implications”. Stroke 2019, 50: e436. PMID: 31718502, DOI: 10.1161/strokeaha.119.027673.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial atherosclerotic diseaseIntracranial atherosclerotic diseaseAtherosclerotic diseaseStroke mechanismClinical implicationsEffect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies
de Havenon A, Muhina HJ, Parker DL, McNally JS, Alexander MD. Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies. American Journal Of Neuroradiology 2019, 40: 1709-1711. PMID: 31515211, PMCID: PMC6785399, DOI: 10.3174/ajnr.a6191.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseAtherosclerotic diseaseContrast administrationMR imaging studiesVessel wall MR imagingSignal intensity changesPlaque enhancementGadolinium administrationVessel wall MRImaging studiesMR imagingLonger durationAdministrationGreater increaseDiseaseDurationCohortTime ElapsedAssessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis
Alexander MD, de Havenon A, Kim SE, Parker DL, McNally JS. Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis. Neuroradiology 2019, 61: 643-650. PMID: 30675639, PMCID: PMC8022353, DOI: 10.1007/s00234-019-02167-3.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseVessel wall magnetic resonance imagingInter-rater agreementLower infundibulumHigh inter-rater agreementVessel wall magnetic resonanceGood inter-rater agreementPost-contrast imagingPresence of enhancementMagnetic resonance imagingPost-contrast imagesRatio of enhancementCulprit lesionIntracranial atherosclerosisAtherosclerotic diseaseInclusion criteriaBlinded reviewersResonance imagingLesion enhancementHigh agreementPlaque signalLesionsInfundibulumObjective dataMagnetic resonance
2017
Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies
Mossa-Basha M, Shibata DK, Hallam DK, de Havenon A, Hippe DS, Becker KJ, Tirschwell DL, Hatsukami T, Balu N, Yuan C. Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies. Stroke 2017, 48: 3026-3033. PMID: 29030476, PMCID: PMC5687293, DOI: 10.1161/strokeaha.117.018227.Peer-Reviewed Original ResearchConceptsIntracranial vessel wall magnetic resonance imagingVessel wall magnetic resonance imagingLuminal imagingIntracranial vasculopathyMagnetic resonance imagingInflammatory vasculopathyWall involvementResonance imagingReversible cerebral vasoconstriction syndromeCerebral vasoconstriction syndromeIntracranial atherosclerotic diseasePattern of involvementAtherosclerotic diseaseLesion eccentricityPostcontrast enhancementClinical dataSyndrome patientsVasculopathyPatient basisPatient analysisDiagnostic agreementSlight agreementDiagnosisDiagnostic confidenceLesionsHigh-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease
de Havenon A, Mossa-Basha M, Shah L, Kim SE, Park M, Parker D, McNally JS. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease. Neuroradiology 2017, 59: 1193-1202. PMID: 28942481, DOI: 10.1007/s00234-017-1925-9.Peer-Reviewed Original ResearchConceptsHigh-resolution vessel wall MRIVessel wall MRIIntracranial atherosclerosisPrognosis of patientsIntracranial atherosclerotic diseasePost-contrast enhancementDiagnostic imaging techniquesHigh field strength MRIIschemic strokeStroke etiologyAtherosclerotic diseaseCerebrovascular diseaseVessel wall morphologyVascular pathologyIntracranial arteriesEnhancement patternRecurrence riskAtherosclerosisTranslational perspectiveVessel wallClinical interpretationMRIStrength MRIDisease
2015
Nonstenotic Culprit Plaque: The Utility of High‐Resolution Vessel Wall MRI of Intracranial Vessels after Ischemic Stroke
de Havenon A, Yuan C, Tirschwell D, Hatsukami T, Anzai Y, Becker K, Sultan-Qurraie A, Mossa-Basha M. Nonstenotic Culprit Plaque: The Utility of High‐Resolution Vessel Wall MRI of Intracranial Vessels after Ischemic Stroke. Case Reports In Radiology 2015, 2015: 356582. PMID: 26346855, PMCID: PMC4543789, DOI: 10.1155/2015/356582.Peer-Reviewed Original ResearchIntracranial atherosclerotic diseaseIschemic strokeThromboembolic eventsClinical eventsHigh-resolution vessel wall MRIMultiple high-risk featuresPatient's clinical eventsPatients thromboembolic eventsHigh-risk featuresHigh-resolution magnetic resonance imagingMagnetic resonance imagingArterial vessel wallVessel wall MRINonstenotic plaquesAntiplatelet therapyCryptogenic strokeStroke workupThromboembolic strokeMedical managementAtherosclerotic diseaseHR-MRIIntracranial vesselsResonance imagingStrokeImaging modalities