Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19
Frontera JA, Melmed K, Fang T, Granger A, Lin J, Yaghi S, Zhou T, Lewis A, Kurz S, Kahn DE, de Havenon A, Huang J, Czeisler BM, Lord A, Meropol SB, Troxel AB, Wisniewski T, Balcer L, Galetta S. Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19. Neurocritical Care 2021, 35: 693-706. PMID: 33725290, PMCID: PMC7962078, DOI: 10.1007/s12028-021-01220-5.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyHospital mortalityTime-dependent Cox proportional hazards modelsSequential Organ Failure Assessment scoreSevere acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Intensive care unit requirementSARS-CoV-2 infectionCOVID-19Cox proportional hazards modelRespiratory syndrome coronavirus 2Longer hospital lengthNew York City hospitalsPrimary neurological diagnosisStructural brain diseaseToxic-metabolic encephalopathyDate of admissionSyndrome coronavirus 2Proportional hazards modelCoronavirus disease 2019Coprimary outcomesHospital deathHospital lengthObservational cohort