2023
Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity
de Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesIncident strokePrimary outcomeHypertensive individualsMatter hyperintensitiesAtherosclerotic cardiovascular disease risk scoreCognitive impairmentCardiovascular disease risk scoreVascular risk factorsCurrent cigarette smokingDisease risk scoreMagnetic resonance imagingLogistic regression modelsRandomization armCerebrovascular eventsVascular riskCigarette smokingPrognostic informationRisk factorsPrognostic abilityRisk scoreCognitive declineResonance imagingDeLong testStrokeHigher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar association
2021
Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study
de Havenon A, Delic A, Stulberg E, Sheibani N, Stoddard G, Hanson H, Theilen L. Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study. JAMA Network Open 2021, 4: e215077. PMID: 33900402, PMCID: PMC8076961, DOI: 10.1001/jamanetworkopen.2021.5077.Peer-Reviewed Original ResearchConceptsHistory of preeclampsiaVascular risk factorsIncident strokeRisk factorsFramingham Heart StudyMarginal structural modelsCohort studyStroke incidenceRelative riskHeart StudyLater lifeTime-varying covariatesMidlife vascular risk factorsPopulation-based cohort studyHigher diastolic blood pressureAbsence of preeclampsiaCholesterol-lowering medicationsDiastolic blood pressureAge 45 yearsAssociation of preeclampsiaBlood pressureMore pregnanciesStudy visitPreeclampsiaMAIN OUTCOMEUsing Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Baradaran H, Delic A, Wong KH, Sheibani N, Alexander M, McNally JS, Majersik JJ, De Havenon A. Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis. Cerebrovascular Diseases Extra 2021, 11: 37-43. PMID: 33601394, PMCID: PMC7989729, DOI: 10.1159/000514373.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersCarotid Intima-Media ThicknessCarotid StenosisFemaleHumansInflammation MediatorsInterleukin-6Ischemic StrokeMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsUltrasonography, DopplerUnited StatesVascular StiffnessConceptsIschemic strokeCarotid distensibilityCarotid stenosisMulti-Ethnic StudyInterleukin-6Primary outcomeRisk factorsInflammation measurementsClinical trial inclusion criteriaSecondary analysisPrimary ischemic strokeIncident ischemic strokeTrial inclusion criteriaVascular risk factorsSystolic blood pressureTraditional risk factorsBaseline study visitCox regression modelIschemic stroke riskStroke risk predictionPrimary prevention effortsUltrasound-derived measurementsIncident strokeMean followPatient age
2020
Diabetic Retinopathy and Risk of Stroke
Wong KH, Hu K, Peterson C, Sheibani N, Tsivgoulis G, Majersik JJ, de Havenon AH. Diabetic Retinopathy and Risk of Stroke. Stroke 2020, 51: 3733-3736. PMID: 33019896, PMCID: PMC7686117, DOI: 10.1161/strokeaha.120.030350.Peer-Reviewed Original ResearchConceptsBlood pressure interventionsRisk of strokeDiabetic retinopathyRandomization armIncident strokePrimary outcomePressure interventionPresence of DRCox proportional hazards modelACCORD Eye StudyRapid vision lossSubsequent stroke eventsCommon microvascular complicationCox regression modelProportional hazards modelMacrovascular complicationsMicrovascular complicationsHazard ratioEye StudyMicrovascular pathologyStroke eventsStudy baselineSerum glucoseVision lossHazards model