2023
Endovascular Therapy for Acute Stroke: New Evidence and Indications
Sahoo A, Abdalkader M, Yamagami H, Huo X, Sun D, Jia B, Weyland C, Diana F, Kaliaev A, Klein P, Bui J, Kasab S, de Havenon A, Zaidat O, Zi W, Yang Q, Michel P, Siegler J, Yaghi S, Hu W, Nguyen T. Endovascular Therapy for Acute Stroke: New Evidence and Indications. Journal Of Neuroendovascular Therapy 2023, 17: 232-242. PMID: 38025253, PMCID: PMC10657733, DOI: 10.5797/jnet.ra.2023-0047.Peer-Reviewed Original ResearchRandomized clinical trialsTreatment of patientsIntravenous thrombolysisEndovascular therapyMechanical thrombectomyClinical trialsAcute ischemic strokeDistal vessel occlusionNon-contrast CTExtended windowOngoing studiesCTA collateralsRescue stentingTandem occlusionsAcute strokeCore infarctIschemic strokeTreatment indicationsCore infarctionVessel occlusionRecent trialsThrombectomyPatientsAdvanced imagingNarrative reviewRecurrence risk in symptomatic intracranial stenosis treated medically in the real world
Yaghi S, Shu L, Goldstein E, Chang A, Kala N, Stretz C, Burton T, Perelstein E, Furie K, Jayaraman M, Torabi R, Moldovan K, de Havenon A, Khatri P, Gebregziabher M, Liebeskind D, Prabhakaran S. Recurrence risk in symptomatic intracranial stenosis treated medically in the real world. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107086. PMID: 37030126, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107086.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisSymptomatic intracranial atherosclerotic stenosisClinical trialsRecurrence riskRecurrent strokeInclusion criteriaReal-world settingMaximal medical treatmentRecurrent stroke rateDual antiplatelet therapyAcute ischemic strokeReal-world cohortSymptomatic intracranial stenosisPharmacological treatment strategiesCox regression modelMeeting inclusion criteriaLow event ratesAntiplatelet therapyStroke RegistryIschemic eventsIschemic strokeWorld CohortHospitalized patientsEarly recurrenceIntracranial stenosis
2022
Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score
Klein P, Shu L, Nguyen TN, Siegler JE, Omran SS, Simpkins AN, Heldner M, de Havenon A, Aparicio HJ, Abdalkader M, Psychogios M, Vedovati MC, Paciaroni M, von Martial R, Liebeskind DS, de Sousa D, Coutinho JM, Yaghi S, Group F. Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score. Journal Of Stroke 2022, 24: 404-416. PMID: 36221944, PMCID: PMC9561213, DOI: 10.5853/jos.2022.01606.Peer-Reviewed Original ResearchCerebral venous thrombosisPoor neurological outcomePoor outcomeNeurological outcomeVenous thrombosisPrognostic scoreRisk factorsInternational multicenter retrospective studyMulticenter retrospective studyMultivariable logistic regressionFuture clinical trialsActive cancerHigher NIHSSConsecutive patientsMedian ageMultivariable analysisRetrospective studyMRS 3Black raceRadiographic characteristicsClinical trialsPrognostic accuracyHigh riskPatientsClinical decision2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee
Masoud H, de Havenon A, Castonguay A, Asif K, Nguyen T, Mehta B, Abdalkader M, Gutierrez S, Leslie‐Mazwi T, Mansour O, Ma A, Czap A, Kenmuir C, Sheth S, Novakovic‐White R, Nour M, Jadhav A, Janardhan V, Hassan A, Liebeskind D, Malik A, Zaidat O. 2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000276.Peer-Reviewed Original ResearchSociety of VascularAcute ischemic strokeLarge vessel occlusionIntravenous thrombolysisNeurology guidelinesPractice UpdateIschemic strokeMechanical thrombectomyVessel occlusionClinical trialsLarge vessel occlusion acute ischemic strokeEmergent large vessel occlusionIschemic stroke patientsRecent clinical trialsClass of recommendationRecent clinical dataClinical trial resultsLevel of evidenceClinical trial dataClinical decision makingStroke patientsCombination therapyClinical dataThrombolysisCurrent evidence
2021
Society of Vascular and Interventional Neurology Standards and Parameters for Guideline Development and Publication
Castonguay A, de Havenon A, Leslie‐Mazwi T, Kenmuir C, Sheth S, Asif K, Nguyen T, Janardhan V, Mansour O, Novakovic R, Hassan A, Liebeskind D, Czap A, Masoud H, Ma A, Nour M, Jadhav A, Malik A, Zaidat O. Society of Vascular and Interventional Neurology Standards and Parameters for Guideline Development and Publication. Stroke Vascular And Interventional Neurology 2021, 1 DOI: 10.1161/svin.121.000112.Peer-Reviewed Original ResearchPractice Parameters CommitteeEvidence-based frameworkSociety of Vascular and Interventional NeurologyPractice updateStandard patient careRandomized clinical trialsInterventional NeurologyField of interventional neurologyClasses of recommendationsGuideline developmentPatient careBrief practiceNeurointerventional practiceClinical trialsAmerican CollegeGuideline statements
2020
Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 "
Taussky P, Agnoletto G, Grandhi R, Alexander MD, Wong KH, Albers GW, de Havenon A. Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 ". Journal Of NeuroInterventional Surgery 2020, 13: 805-808. PMID: 33077580, PMCID: PMC8093992, DOI: 10.1136/neurintsurg-2020-016548.Peer-Reviewed Original ResearchConceptsEndovascular thrombectomyDEFUSE 3Statin usePrimary outcomeInclusion criteriaPredictive scoreHealth Stroke Scale scoreDEFUSE 3 studyEVT-treated patientsSecondary cohort analysisBaseline National InstitutesStroke Scale scoreHistory of diabetesPrediction of deathSelective inclusion criteriaUnivariate regression analysisHigh-risk categoryPotential predictive variablesEVT patientsPatient ageEndovascular therapyImaging evaluationPreprocedural variablesClinical trialsLethal outcome
2019
Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis
Yaghi S, Khatri P, de Havenon A, Yeatts S, Chang AD, Cutting S, Mac Grory B, Burton T, Jayaraman MV, McTaggart RA, Fiorella D, Derdeyn C, Zaidat OO, Dehkharghani S, Amin-Hanjani S, Furie K, Prahbakaran S, Liebeskind D. Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis. Journal Of NeuroInterventional Surgery 2019, 12: 374. PMID: 31484697, PMCID: PMC8022354, DOI: 10.1136/neurintsurg-2019-015225.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial atherosclerosisAngioplasty/stentingPrimary outcomeSAMMPRIS trialLesion lengthPeri-procedural strokeSevere intracranial stenosisStroke/deathOdds of strokeNew clinical trialsProcedure-specific variablesLogistic regression analysisPatient-specific variablesModest predictive valueSymptomatic severe intracranial stenosisIntracranial atherosclerosisSmoking historySmoking statusIntracranial stenosisFDA indicationClinical trialsPatientsReliable biomarkersStentingPredictive valueSubclinical Cerebrovascular Disease: Epidemiology and Treatment
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L. Subclinical Cerebrovascular Disease: Epidemiology and Treatment. Current Atherosclerosis Reports 2019, 21: 39. PMID: 31350593, PMCID: PMC8011954, DOI: 10.1007/s11883-019-0799-1.Peer-Reviewed Original ResearchConceptsMedical managementRisk factorsAggressive medical managementSilent brain infarctsOptimal medical treatmentVascular risk factorsDevelopment of dementiaBest medical managementImportant risk factorLate-life depressionCommon clinical scenariosWhite matter hyperintensitiesT2-weighted MRISusceptibility-weighted MRIEvidence-based approachBrain infarctsCerebral microbleedsCerebrovascular diseaseGait instabilityBrain healthClinical equipoiseWorse outcomesClinical trialsMatter hyperintensitiesEpidemiologic studies
2017
Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage
McNally JS, Kim SE, Mendes J, Hadley JR, Sakata A, De Havenon AH, Treiman GS, Parker DL. Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage. Magnetic Resonance Insights 2017, 10: 1178623x17694150. PMID: 28469441, PMCID: PMC5348123, DOI: 10.1177/1178623x17694150.Peer-Reviewed Original ResearchCarotid intraplaque hemorrhageFuture stroke riskIntraplaque hemorrhageStroke riskCarotid artery atherosclerosisPercent diameter stenosisMagnetic resonance imaging (MRI) detectionT1-weighted MRI sequencesMagnetic resonance imaging sequenceArtery atherosclerosisIschemic strokeStroke etiologyDiameter stenosisClinical trialsHemorrhageClinical useMajor causeStroke sourcesMRI sequencesMRINeck coilImaging sequenceRiskLumenImaging