2023
An exploratory study on the possible association of serum etonogestrel concentrations with mood concerns and symptoms among contraceptive implant users
Diamond B, Sheeder J, Lazorwitz A. An exploratory study on the possible association of serum etonogestrel concentrations with mood concerns and symptoms among contraceptive implant users. Contraception 2023, 129: 110298. PMID: 37802462, PMCID: PMC10842501, DOI: 10.1016/j.contraception.2023.110298.Peer-Reviewed Original ResearchConceptsMood-related side effectsContraceptive implant usersENG implant usersInter-individual variabilitySide effectsImplant usersEtonogestrel contraceptive implant usersMood changesWide inter-individual variabilitySerum etonogestrel concentrationsPHQ-9 scoresSerum drug levelsLiquid chromatography-mass spectrometry assaySubset of participantsEtonogestrel concentrationsPrimary outcomePharmacokinetic variabilityMood concernsBaseline questionnairePHQ-9Blood drawDrug levelsMood symptomsImplant usePossible association
2022
Short-notice cancellations of laparoscopic permanent contraception
Masten M, Larrea N, Schultz C, Lazorwitz A. Short-notice cancellations of laparoscopic permanent contraception. Contraception 2022, 114: 49-53. PMID: 35545130, DOI: 10.1016/j.contraception.2022.04.013.Peer-Reviewed Original ResearchMeSH KeywordsAppointments and SchedulesContraceptionFemaleHumansLaparoscopyOperating RoomsRetrospective StudiesSterilization, TubalConceptsAcademic county hospitalSurgery cancellation ratesHigher cancellation rateCancellation ratePermanent contraceptionCounty HospitalContraceptive methodsAcademic tertiary care hospitalRetrospective cohort studyRetrospective chart reviewTertiary care hospitalPreferred contraceptive methodHealth care systemElectronic health recordsMost cancellationsChart reviewCohort studyCare hospitalSubsequent pregnancySurgery dateEffective contraceptionTubal sterilizationCommon reasonPatientsSurgery
2021
Etonogestrel contraceptive implant uptake and safety among solid organ transplant recipients
Lew J, Sheeder J, Lazorwitz A. Etonogestrel contraceptive implant uptake and safety among solid organ transplant recipients. Contraception 2021, 104: 556-560. PMID: 34147509, PMCID: PMC8502202, DOI: 10.1016/j.contraception.2021.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultContraceptive Agents, FemaleDesogestrelDrug ImplantsFemaleHumansMiddle AgedOrgan TransplantationPregnancyRetrospective StudiesYoung AdultConceptsSolid organ transplant recipientsOrgan transplant recipientsReproductive-age womenEtonogestrel contraceptive implantContraceptive implant usersTransplant recipientsContraceptive implantsCommon transplant-related complicationPost-transplant infectionsSafe contraceptive optionTransplant-related outcomesRetrospective cohort studyTransplant-related complicationsGraft-related complicationsSide effect profileTertiary medical centerRisk of pregnancyImplant usersContraceptive implant useAdditional health risksPregnancy patternsCohort studyGraft complicationsGraft rejectionEffect profile
2020
An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users
Lazorwitz A, Dindinger E, Harrison M, Aquilante C, Sheeder J, Teal S. An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users. Contraception 2020, 102: 180-185. PMID: 32407811, PMCID: PMC7483263, DOI: 10.1016/j.contraception.2020.05.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultContraceptive Agents, FemaleDesogestrelDrug ImplantsFemaleHumansRetrospective StudiesWeight GainConceptsBody mass indexEtonogestrel contraceptive implant usersEstrogen receptor 1Contraceptive implant usersContraceptive implant useWeight gainImplant useWeight changeImplant insertionEnrollment body mass indexMedian body mass indexGenetic variantsReproductive-aged womenMedian weight changeImplant usersExogenous steroid hormonesEstrogen receptor 1 geneReceptor 1 genePhysiologic plausibilityEtonogestrel implantsMetabolic syndromeMedical recordsContraceptive counselingRetrospective analysisIndividualized counseling
2019
Pre- and post-operative counseling for women on hormonal contraceptives receiving sugammadex at an academic hospital
Lazorwitz A, Dindinger E, Aguirre N, Sheeder J. Pre- and post-operative counseling for women on hormonal contraceptives receiving sugammadex at an academic hospital. Journal Of Anesthesia 2019, 34: 294-297. PMID: 31865457, PMCID: PMC8496978, DOI: 10.1007/s00540-019-02725-2.Peer-Reviewed Original ResearchMeSH KeywordsContraceptionContraceptive AgentsCounselingFemaleHumansPregnancyRetrospective StudiesSugammadexConceptsHormonal contraceptionDrug-drug interactionsUnintended pregnancyPost-operative counselingRetrospective chart reviewChart reviewRisk patientsHormonal contraceptivesColorado HospitalAcademic hospitalFDA labelContraceptive methodsSugammadexContraceptionPatientsWomenUnnecessary riskPregnancyHospitalCounselingExposureMedicationsContraceptivesProgestinsEstrogenInfluence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.
Lazorwitz A, Aquilante C, Oreschak K, Sheeder J, Guiahi M, Teal S. Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics And Gynecology 2019, 133: 783-794. PMID: 30870275, PMCID: PMC6448146, DOI: 10.1097/aog.0000000000003189.Peer-Reviewed Original ResearchConceptsSerum etonogestrel concentrationsBody mass indexContraceptive implant usersEtonogestrel concentrationsSteroid hormone metabolismImplant useGenetic variantsHepatic enzyme inducersReproductive-age womenImplant usersHormone metabolismPersonalized medicine approachVariant allele frequencyOvulatory suppressionEtonogestrel implantsMass indexHormonal contraceptionConcomitant useWomen's healthPg/Medicine approachParticipant characteristicsSteroid hormonesEnzyme inducersPharmacogenomic investigations