PCBrainAge: A Brain‐Specific AD‐Associated DNA Methylation Clock
Thrush K, Markov Y, Higgins‐Chen A, Morgan L. PCBrainAge: A Brain‐Specific AD‐Associated DNA Methylation Clock. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.069230.Peer-Reviewed Original ResearchΕ4 carrier statusAlzheimer's diseasePathogenesis of ADCarrier statusAPOE ε4 carrier statusAD diagnostic criteriaNeuropathological changesNeuropathological criteriaAD developmentBlood measuresDiagnostic criteriaAD riskBrain samplesBrain tissueClinical diagnosisNovel predictorCortical measuresDiseaseMolecular changesRecent evidenceSignificant differencesBlood tissueBloodDNA methylation agingDNA methylation clock