PCBrainAge: A Brain‐Specific AD‐Associated DNA Methylation Clock
Thrush K, Markov Y, Higgins‐Chen A, Morgan L. PCBrainAge: A Brain‐Specific AD‐Associated DNA Methylation Clock. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.069230.Peer-Reviewed Original ResearchΕ4 carrier statusAlzheimer's diseasePathogenesis of ADCarrier statusAPOE ε4 carrier statusAD diagnostic criteriaNeuropathological changesNeuropathological criteriaAD developmentBlood measuresDiagnostic criteriaAD riskBrain samplesBrain tissueClinical diagnosisNovel predictorCortical measuresDiseaseMolecular changesRecent evidenceSignificant differencesBlood tissueBloodDNA methylation agingDNA methylation clockAging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease
Thrush KL, Bennett DA, Gaiteri C, Horvath S, Dyck CHV, Higgins-Chen AT, Levine ME. Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease. Aging 2022, 14: 5641-5668. PMID: 35907208, PMCID: PMC9365556, DOI: 10.18632/aging.204196.Peer-Reviewed Original ResearchConceptsDisease risk increasesBrain agingAD brain tissueΕ4 carrier statusClinical AD dementiaMultiple brain regionsEpigenetic alterationsReligious Orders StudyAD dementiaTest-retest reliabilityCortical samplesAD riskEpigenetic age accelerationSubcortical regionsPathologic ADAlzheimer's diseaseBrain regionsBrain tissueEpigenetic clocksCarrier statusStrong associationRush MemoryAge accelerationRisk increaseAging Project