Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice
Xu EY, Vosburgh E, Wong C, Tang LH, Notterman DA. Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice. Oncotarget 2020, 11: 2718-2739. PMID: 32733644, PMCID: PMC7367653, DOI: 10.18632/oncotarget.27660.Peer-Reviewed Original ResearchTumor suppressor geneCooperative functionMolecular mechanismsTumor suppressor RB1Tumorigenic effectsCre-loxP systemGenetic analysisPTEN pathwaySuppressor geneGenesNeuroendocrine tumorigenesisGenetic alterationsDeletionPTENTrp53MeninHomozygous deletionExpressing cellsPathwayPRBSignificant roleMiceTumorigenesisPreclinical murine modelsMechanism