2019
On the magnetic field dependence of deuterium metabolic imaging
de Graaf R, Hendriks AD, Klomp DWJ, Kumaragamage C, Welting D, de Castro C, Brown PB, McIntyre S, Nixon TW, Prompers JJ, De Feyter HM. On the magnetic field dependence of deuterium metabolic imaging. NMR In Biomedicine 2019, 33: e4235. PMID: 31879985, PMCID: PMC7141779, DOI: 10.1002/nbm.4235.Peer-Reviewed Original Research
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approachMinimum echo time PRESS‐based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses
Kumaragamage C, Madularu D, Mathieu AP, Lupinsky D, de Graaf R, Near J. Minimum echo time PRESS‐based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses. Magnetic Resonance In Medicine 2018, 80: 1279-1288. PMID: 29427395, DOI: 10.1002/mrm.27119.Peer-Reviewed Original Research
2013
In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Coman D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.Peer-Reviewed Original ResearchConceptsK-spaceNonexchanging protonsThree-dimensional molecular imagingParamagnetic lanthanide ionsRedundant deviationChemical shift imagingField of viewMolecular imaging capabilitiesMolecular imagingRapid data acquisitionProton detectionLanthanide ionsTens of minutesImaging capabilitiesMacrocyclic chelatesSpectroscopic signalsMacrocyclicCSI experimentsRelaxation timeHigh spatiotemporal resolutionParamagnetic agents
2012
In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy
van der Hel W, van Eijsden P, Bos IW, de Graaf R, Behar KL, van Nieuwenhuizen O, de Graan P, Braun KP. In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy. NMR In Biomedicine 2012, 26: 132-140. PMID: 22806932, DOI: 10.1002/nbm.2828.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyStatus epilepticusSynthase immunoreactivityNeuronal lossHippocampal pathologyLobe epilepsyDevelopment of TLECholine-containing compound concentrationsChildhood status epilepticusPre-epileptic stateSpontaneous recurrent seizuresVivo MRSJuvenile rat modelHippocampal injuryChronic epilepsyRecurrent seizuresSpontaneous seizuresNeurotransmitter imbalanceParvalbumin immunoreactivityVivo immunohistochemistryInhibitory neurotransmissionΓ-aminobutyric acidEpileptogenic processMRS findingsNeuronal death
2011
Dynamic multi-coil shimming of the human brain at 7T
Juchem C, Nixon TW, McIntyre S, Boer VO, Rothman DL, de Graaf RA. Dynamic multi-coil shimming of the human brain at 7T. Journal Of Magnetic Resonance 2011, 212: 280-288. PMID: 21824794, PMCID: PMC3183127, DOI: 10.1016/j.jmr.2011.07.005.Peer-Reviewed Original Research
2009
In vivo neurochemical profiling of rat brain by 1H‐[13C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission
Van Eijsden P, Behar KL, Mason GF, Braun KP, De Graaf RA. In vivo neurochemical profiling of rat brain by 1H‐[13C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission. Journal Of Neurochemistry 2009, 112: 24-33. PMID: 19818103, PMCID: PMC2843425, DOI: 10.1111/j.1471-4159.2009.06428.x.Peer-Reviewed Original ResearchConceptsGABAergic neurotransmissionRat brainGlutamatergic/GABAergic neurotransmissionLow GABA concentrationsInhibitory neurotransmissionGlutamatergic neurotransmissionCerebral energeticsGABA concentrationNeurotransmissionBrain functionNeurotransmitter fluxEnergy metabolismNeurochemical profilingVivoBrainHigh magnetic fieldsGABAergicExcitatoryMagnetic fieldIn situ 3D magnetic resonance metabolic imaging of microwave‐irradiated rodent brain: a new tool for metabolomics research
De Graaf RA, Chowdhury GM, Brown PB, Rothman DL, Behar KL. In situ 3D magnetic resonance metabolic imaging of microwave‐irradiated rodent brain: a new tool for metabolomics research. Journal Of Neurochemistry 2009, 109: 494-501. PMID: 19200336, PMCID: PMC2843429, DOI: 10.1111/j.1471-4159.2009.05967.x.Peer-Reviewed Original Research
2003
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity
PATEL AB, DE GRAAF R, MASON GF, ROTHMAN DL, SHULMAN RG, BEHAR KL. Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity. Annals Of The New York Academy Of Sciences 2003, 1003: 452-453. PMID: 14684486, DOI: 10.1196/annals.1300.050.Peer-Reviewed Original Research
2001
Single‐shot diffusion trace 1H NMR spectroscopy
de Graaf R, Braun K, Nicolay K. Single‐shot diffusion trace 1H NMR spectroscopy. Magnetic Resonance In Medicine 2001, 45: 741-748. PMID: 11323799, DOI: 10.1002/mrm.1101.Peer-Reviewed Original Research
2000
In Vivo 31P-NMR Diffusion Spectroscopy of ATP and Phosphocreatine in Rat Skeletal Muscle
de Graaf R, van Kranenburg A, Nicolay K. In Vivo 31P-NMR Diffusion Spectroscopy of ATP and Phosphocreatine in Rat Skeletal Muscle. Biophysical Journal 2000, 78: 1657-1664. PMID: 10733948, PMCID: PMC1300762, DOI: 10.1016/s0006-3495(00)76717-8.Peer-Reviewed Original Research
1999
Magnetic coupling of creatine/phosphocreatine protons in rat skeletal muscle, as studied by 1H‐magnetization transfer MRS
Kruiskamp M, de Graaf R, van Vliet G, Nicolay K. Magnetic coupling of creatine/phosphocreatine protons in rat skeletal muscle, as studied by 1H‐magnetization transfer MRS. Magnetic Resonance In Medicine 1999, 42: 665-672. PMID: 10502754, DOI: 10.1002/(sici)1522-2594(199910)42:4<665::aid-mrm7>3.0.co;2-9.Peer-Reviewed Original ResearchOff‐resonance metabolite magnetization transfer measurements on rat brain in situ
de Graaf R, van Kranenburg A, Nicolay K. Off‐resonance metabolite magnetization transfer measurements on rat brain in situ. Magnetic Resonance In Medicine 1999, 41: 1136-1144. PMID: 10371445, DOI: 10.1002/(sici)1522-2594(199906)41:6<1136::aid-mrm9>3.0.co;2-g.Peer-Reviewed Original ResearchSpatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain
Dijkhuizen R, de Graaf R, Garwood M, Tulleken K, Nicolay K. Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 376-379. PMID: 10197507, DOI: 10.1097/00004647-199904000-00003.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaFocal ischemic rat brainAcute focal cerebral ischemiaIschemic rat brainMagnetic resonance spectroscopic imaging techniquesTherapeutic intervention strategiesBorderzone areasIschemic penumbraIschemic coreSalvageable penumbraLactate formationRat modelRat brainEarly identificationIschemiaViable tissueIntervention strategiesInfusionPenumbraImaging techniquesLactateEnrichment of lactateIn vivo observation of lactate methyl proton magnetization transfer in rat C6 glioma
Luo Y, Rydzewski J, de Graaf R, Gruetter R, Garwood M, Schleich T. In vivo observation of lactate methyl proton magnetization transfer in rat C6 glioma. Magnetic Resonance In Medicine 1999, 41: 676-685. PMID: 10332842, DOI: 10.1002/(sici)1522-2594(199904)41:4<676::aid-mrm5>3.0.co;2-d.Peer-Reviewed Original ResearchChanges in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain
Dijkhuizen R, de Graaf R, Tulleken K, Nicolay K. Changes in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 341-349. PMID: 10078886, DOI: 10.1097/00004647-199903000-00012.Peer-Reviewed Original ResearchConceptsNeonatal rat brainMetabolite apparent diffusion coefficientsGlobal ischemiaApparent diffusion coefficientADC dropExcitotoxic injuryRat brainN-methyl-D-aspartate (NMDA) injectionAcute cerebral ischemiaDiffusion-weighted magnetic resonance imagingBrain metabolite levelsMagnetic resonance imagingBrain temperature changesTissue deoxygenationCerebral ischemiaNMDA injectionContralateral valuesCytotoxic edemaMetabolites taurineBrain tissue waterN-acetylaspartateIschemiaWater apparent diffusion coefficientResonance imagingEarly alterations
1998
In vivo 1H MR spectroscopic imaging and difusion weighted mri in experimental hydrocephalus
Braun K, de Graaf R, Vandertop W, Gooskens R, Tulleken K, Nicolay K. In vivo 1H MR spectroscopic imaging and difusion weighted mri in experimental hydrocephalus. Magnetic Resonance In Medicine 1998, 40: 832-839. PMID: 9840827, DOI: 10.1002/mrm.1910400608.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingExperimental hydrocephalusApparent diffusion coefficientInjection of kaolinIschemic metabolic changesWhite matter edemaDegree of ventriculomegalyHigher lactate levelsGray matter regionsProgressive ventriculomegalyCerebral edemaCerebral ischemiaVentricular enlargementHydrocephalic ratsKaolin injectionRat modelAccumulation of lactateDifferent time coursesLactate levelsCerebrospinal fluidCisterna magnaVentricular expansionHydrocephalusWhole brainSpectroscopic imagingAdiabatic water suppression using frequency selective excitation
de Graaf R, Nicolay K. Adiabatic water suppression using frequency selective excitation. Magnetic Resonance In Medicine 1998, 40: 690-696. PMID: 9797151, DOI: 10.1002/mrm.1910400508.Peer-Reviewed Original Research
1997
Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study
Braun K, Dijkhuizen R, de Graaf R, Nicolay K, Vandertop W, Gooskens R, Tulleken K. Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study. Brain Research 1997, 757: 295-298. PMID: 9200761, DOI: 10.1016/s0006-8993(97)00345-4.Peer-Reviewed Original Research