1999
Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain
Dijkhuizen R, de Graaf R, Garwood M, Tulleken K, Nicolay K. Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 376-379. PMID: 10197507, DOI: 10.1097/00004647-199904000-00003.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaFocal ischemic rat brainAcute focal cerebral ischemiaIschemic rat brainMagnetic resonance spectroscopic imaging techniquesTherapeutic intervention strategiesBorderzone areasIschemic penumbraIschemic coreSalvageable penumbraLactate formationRat modelRat brainEarly identificationIschemiaViable tissueIntervention strategiesInfusionPenumbraImaging techniquesLactateEnrichment of lactate
1998
In vivo 1H MR spectroscopic imaging and difusion weighted mri in experimental hydrocephalus
Braun K, de Graaf R, Vandertop W, Gooskens R, Tulleken K, Nicolay K. In vivo 1H MR spectroscopic imaging and difusion weighted mri in experimental hydrocephalus. Magnetic Resonance In Medicine 1998, 40: 832-839. PMID: 9840827, DOI: 10.1002/mrm.1910400608.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingExperimental hydrocephalusApparent diffusion coefficientInjection of kaolinIschemic metabolic changesWhite matter edemaDegree of ventriculomegalyHigher lactate levelsGray matter regionsProgressive ventriculomegalyCerebral edemaCerebral ischemiaVentricular enlargementHydrocephalic ratsKaolin injectionRat modelAccumulation of lactateDifferent time coursesLactate levelsCerebrospinal fluidCisterna magnaVentricular expansionHydrocephalusWhole brainSpectroscopic imaging