2020
Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior
Xu J, Galardi MM, Pok B, Patel KK, Zhao CW, Andrews JP, Singla S, McCafferty CP, Feng L, Musonza ET, Kundishora AJ, Gummadavelli A, Gerrard JL, Laubach M, Schiff ND, Blumenfeld H. Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior. Journal Of Neuroscience 2020, 40: 7343-7354. PMID: 32826310, PMCID: PMC7534908, DOI: 10.1523/jneurosci.1370-20.2020.Peer-Reviewed Original ResearchConceptsDeep brain stimulationCentral lateral nucleusBilateral deep brain stimulationCortical slow-wave activityPostictal stateSlow wave activityPostictal periodImpaired consciousnessRefractory epilepsyLateral nucleusBrain stimulationNatural slow-wave sleepModest behavioral improvementCortical slow wavesNovel therapeutic strategiesSlow-wave sleepDisorders of consciousnessBehavioral tasksDepressed consciousnessDBS treatmentThalamic stimulationElectrical hippocampal stimulationFemale ratsHigh success rateRat model
2000
Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networks