2024
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
Sieu L, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse R, Perrenoud Q, Picciotto M, Cardin J, Blumenfeld H. Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Cell Reports 2024, 43: 115012. PMID: 39643969, DOI: 10.1016/j.celrep.2024.115012.Peer-Reviewed Original ResearchCortical slow wavesFocal seizuresBehavioral responsesAuditory stimuliImpaired behavioral responsesFocal temporal lobe seizuresImpaired consciousnessMouse modelAwake mouse modelResponses to auditory stimuliBehavioral responses to auditory stimuliDecreased cortical arousalImpaired behaviorSlow wavesTemporal lobe seizuresCholinergic releaseModel of focal seizuresHigh-frequency activityCortical functionCortical arousalDepressed cortical functionSubcortical arousalArousalAcetylcholine releaseRat model
2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal system