2020
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy. Translational Oncology 2020, 13: 100839. PMID: 32763504, PMCID: PMC7408331, DOI: 10.1016/j.tranon.2020.100839.Peer-Reviewed Original ResearchHuman lung cancer cellsA549 human lung cancer cellsMolecular MRI techniqueTumor-bearing miceLung cancer cellsClonogenic survival assaysVivo radiosensitizationRadiation therapySolid tumorsTumor cell metabolismTumorsEnhanced radiosensitivityTumor cellsMR imagingSurvival assaysMRI techniquesCancer cellsTreatment planningRadiotherapyTumor coreGeneral hallmarkRadiotherapy treatment planningRadiosensitivityPeptide deliveryDelivery
2017
Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH
Rao JU, Coman D, Walsh JJ, Ali MM, Huang Y, Hyder F. Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH. Scientific Reports 2017, 7: 7865. PMID: 28801587, PMCID: PMC5554228, DOI: 10.1038/s41598-017-07609-7.Peer-Reviewed Original ResearchConceptsU251 tumorsTumor microenvironmentT2-weighted MRITherapeutic responseUntreated ratsTumor volumeRat brainTumor growthTherapeutic influenceGlioma growthPeritumoral regionRatsApoptosis inductionTumorsGliomasTumor corePhysiological readoutsExtracellular pHAcidic pHeTumor boundariesProliferationMicroenvironment