2015
Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks
Kannurpatti SS, Sanganahalli BG, Herman P, Hyder F. Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR In Biomedicine 2015, 28: 1579-1588. PMID: 26439799, PMCID: PMC4621005, DOI: 10.1002/nbm.3421.Peer-Reviewed Original ResearchConceptsSimilar dose-dependent decreaseDose-dependent decreaseCaudate putamenBrain regionsBlood oxygen level-dependent fluctuationsBrain energy metabolismLevel-dependent fluctuationsBrain functional organizationSomatosensory cortexAnesthetized ratsDifferent functional networksFunctional organizationDrug treatmentVascular densityHippocampal regionThalamic regionsDifferent physiological impactsBOLD fluctuationsRSFC networksIntrinsic activityState fMRINeural signalingBrain networksPutamenFMRI brain networks
2004
Glutamate-induced differential mitochondrial response in young and adult rats
Kannurpatti S, Sanganahalli B, Mishra S, Joshi P, Joshi N. Glutamate-induced differential mitochondrial response in young and adult rats. Neurochemistry International 2004, 44: 361-369. PMID: 14643754, DOI: 10.1016/s0197-0186(03)00164-5.Peer-Reviewed Original ResearchConceptsAdult ratsLDH releaseYoung ratsIntracellular calciumLactate dehydrogenaseReactive oxygen speciesExcitatory amino acid glutamateIntracellular calcium changesGlutamate-induced increaseTreatment of slicesGlutamate-induced decreaseAge groupsInfluence of glutamateMitochondrial depolarizationAmino acid glutamateMitochondrial inhibitor rotenoneCortical slicesCalcium changesReactive oxygen species formationNeuronal cell deathGlutamate stimulationGlutamate treatmentMitochondrial functionAcid glutamateCa(2+