Zeynep Busra Zengin
Hospital ResidentCards
About
Research
Publications
2025
Microbiome Modulation for the Treatment of Solid Neoplasms
Barragan-Carrillo R, Zengin Z, Pal S. Microbiome Modulation for the Treatment of Solid Neoplasms. Journal Of Clinical Oncology 2025, 43: 2734-2738. PMID: 40644647, PMCID: PMC12352565, DOI: 10.1200/jco-25-00374.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerImmune checkpoint inhibitorsRenal cell carcinomaResponse to immune checkpoint inhibitorsImmune checkpoint inhibitor benefitImmune checkpoint inhibitor initiationTreatment of solid neoplasmsICI-based regimensCell lung cancerDietary fiber intakeAssociated with higher ratesFecal microbiota transplantationMicrobiome modulationCheckpoint inhibitorsGut microbiomeCell carcinomaSolid neoplasmsPrimary resistanceShorter survivalClinical outcomesPreclinical studiesTreatment responseFiber intakeLung cancerClinical activityLong-term clinical outcomes with nivolumab/ipilimumab with or without Clostridium butyricum MIYAIRI588 in metastatic renal cell carcinoma (mRCC): A randomized phase Ib clinical trial.
Zugman M, Ebrahimi H, Meza L, Barragan-Carrillo R, Li X, Llamas-Quitiquit M, Hsu J, Zengin Z, Castro D, Mercier B, Jaime-Casas S, Chehrazi-Raffle A, Trent J, Lee P, Takahashi M, Dorff T, Caporaso G, Lee K, Pal S, Dizman N. Long-term clinical outcomes with nivolumab/ipilimumab with or without Clostridium butyricum MIYAIRI588 in metastatic renal cell carcinoma (mRCC): A randomized phase Ib clinical trial. Journal Of Clinical Oncology 2025, 43: 4550-4550. DOI: 10.1200/jco.2025.43.16_suppl.4550.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaProgression-free survivalClinical outcomesOverall survivalMedian progression-free survivalRandomized phase I trialTime of data cutoffPhase Ib clinical trialLong-term follow-up dataLong-term clinical outcomesObjective response rateDisease control ratePhase I trialRenal cell carcinomaSystemic immune responsesNewly diagnosed patientsFollow-up dataImproving clinical outcomesMedian OSSarcomatoid histologyCell histologyData cutoffIntermediate/high riskCell carcinomaI trialGenomic landscape and clinical characteristics of patients (pts) with neuroendocrine prostate cancer (NEPC) with or without aggressive variant prostate cancer characterized by molecular signature (AVPC-MS).
Ebrahimi H, Barragan-Carrillo R, Zugman M, Jaime-Casas S, Shah K, Castro D, Mercier B, Zengin Z, Meza L, Li X, Hsu J, Zang P, Dizman N, Nguyen C, Tripathi A, Dorff T, Pal S, Chehrazi-Raffle A. Genomic landscape and clinical characteristics of patients (pts) with neuroendocrine prostate cancer (NEPC) with or without aggressive variant prostate cancer characterized by molecular signature (AVPC-MS). Journal Of Clinical Oncology 2025, 43: 5087-5087. DOI: 10.1200/jco.2025.43.16_suppl.5087.Peer-Reviewed Original ResearchNeuroendocrine prostate cancerTumor mutational burdenClinical characteristicsProstate cancerAggressive variant prostate cancerPrevalence of genomic alterationsHigh tumor mutational burdenClinical characteristics of patientsAndrogen receptor inhibitorsPersonalized treatment approachesFisher's exact testCharacteristics of patientsMicrosatellite instability-highIndividuals aged >Mutational burdenPathological confirmationPTEN alterationsReceptor inhibitorsNo significant differenceAggressive subtypeGenomic surrogateExact testGenomic alterationsClinical trialsTwo-proportion z-testComparative Genomic Characterization of Small Cell Carcinoma of the Bladder Compared With Urothelial Carcinoma and Small Cell Lung Carcinoma
Jaime-Casas S, Chawla N, Salgia N, Mercier B, Govindarajan A, Li X, Castro D, Ebrahimi H, Barragan-Carrillo R, Zang P, LeVee A, Zugman M, Dizman N, Hsu J, Meza L, Zengin Z, Chehrazi-Raffle A, Dorff T, Pal S, Tripathi A. Comparative Genomic Characterization of Small Cell Carcinoma of the Bladder Compared With Urothelial Carcinoma and Small Cell Lung Carcinoma. JCO Precision Oncology 2025, 9: e2400947. PMID: 40209138, DOI: 10.1200/po-24-00947.Peer-Reviewed Original ResearchConceptsSmall cell bladder cancerSmall cell lung cancerUrothelial carcinomaGenomic alterationsBladder cancerSmall cell lung cancer patientsSmall cell lung carcinomaSmall cell carcinomaRare histologic variantCell lung carcinomaAggressive disease courseCell lung cancerPathogenic genomic alterationsImproving clinical outcomesTreated with approachesHistological variantsCell carcinomaHistological groupsLung carcinomaClinical outcomesPoor outcomeRetrospective natureDisease courseLung cancerGenomic profilingEligibility Criteria in Advanced Urothelial Cancer Clinical Trials: An Assessment of Modernization and Inclusion
Mercier B, Govindarajan A, Castro D, Li X, Philip E, Feng M, Prajapati S, Chan E, Lee K, Sehgal I, Patel J, O'Dell A, Chehrazi‐Raffle A, Ebrahimi H, Rock A, Zengin Z, Meza L, Dizman N, Hsu J, Liu S, Dorff T, Pal S, Tripathi A. Eligibility Criteria in Advanced Urothelial Cancer Clinical Trials: An Assessment of Modernization and Inclusion. Cancer Medicine 2025, 14: e70696. PMID: 40145383, PMCID: PMC11947756, DOI: 10.1002/cam4.70696.Peer-Reviewed Original ResearchConceptsHepatitis B/C infectionHIV infectionClinical trialsConcurrent malignancyBrain metastasesVariant histologyEligibility criteriaPresence of brain metastasesAmerican Society of Clinical OncologyMetastatic urothelial cancerFisher's exact testType of therapyContemporary clinical trialsFriends of Cancer ResearchInclusion of patientsUrothelial cancerExact testClinical OncologyTherapy efficacyCancer clinical trialsCancer trialsHIVPatientsExclusion criteriaInfectionImpact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma
Castro D, Gebrael G, Meza L, Li X, Tripathi N, Tandar C, Sayegh N, Zengin Z, Chehrazi-Raffle A, Govindarajan A, Dizman N, Barragan-Carrillo R, Ebrahimi H, Mercier B, Chawla N, Jaime-Casas S, Salgia N, Zugman M, Hsu J, Philip E, Bergerot C, Agarwal N, Pal S. Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma. JCO Oncology Advances 2025 DOI: 10.1200/oa.24.00015.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaProgression-free survivalImpact of insurance statusOverall survivalRenal cell carcinomaSurvival outcomesCell carcinomaAssociated with significantly better PFSAssociated with significantly better survival outcomesAssociated with better progression-free survivalInsurance statusFirst-line systemic therapyMedicaid/no insuranceBetter survival outcomesKaplan-Meier methodLog-rank testAssociated with lower riskSystemic therapyPrimary insurance typeNo significant differenceNational Cancer Institute-designated cancer centerInstitutional databasePrivate insuranceCancer CenterLow riskReal-Time Monitoring in Renal Cell Carcinoma With Circulating Tumor DNA: A Step Forward, But How Far?
Zengin Z, Kotecha R. Real-Time Monitoring in Renal Cell Carcinoma With Circulating Tumor DNA: A Step Forward, But How Far? JCO Precision Oncology 2025, 9: e2500053. PMID: 40020208, DOI: 10.1200/po-25-00053.Peer-Reviewed Original ResearchLocal definitive therapy (LDT) utilization patterns and outcomes in chromophobe renal cell carcinoma (chRCC) with metachronous metastasis: A multi-institution study.
Dizman N, Doshi S, Knezevic A, Feinaj A, Sayegh N, Hobeika C, Alaghehbandan R, Rives H, Zengin Z, Braun D, Zibelman M, McGregor B, Hammers H, Ged Y, Ornstein M, Msaouel P, Hahn A, Voss M. Local definitive therapy (LDT) utilization patterns and outcomes in chromophobe renal cell carcinoma (chRCC) with metachronous metastasis: A multi-institution study. Journal Of Clinical Oncology 2025, 43: 503-503. DOI: 10.1200/jco.2025.43.5_suppl.503.Peer-Reviewed Original ResearchLocal definitive therapySarcomatoid dedifferentiationMetachronous metastasesSystemic treatmentST cohortDuration of disease controlChromophobe renal cell carcinomaTreatment characteristics of patientsMetastatic disease diagnosisSingle-organ metastasisTreatment-free intervalTreatment-free survivalKaplan-Meier methodRenal cell carcinomaFisher's exact testCharacteristics of patientsMulti-institutional studyWilcoxon rank sum testRank sum testMetastatic sitesSurgical resectionDefinitive therapyRare subtypeMedian intervalCell carcinomaCabozantinib (cabo) and nivolumab (nivo) with or without CBM588 in patients with metastatic renal cell carcinoma: Updated clinical outcomes of a phase I study.
Ebrahimi H, Meza L, Dizman N, Barragan-Carrillo R, Li X, Llamas-Quitiquit M, Hsu J, Zengin Z, Castro D, Mercier B, Zugman M, Jaime-Casas S, Chehrazi-Raffle A, Trent J, Lee P, Takahashi M, Dorff T, Caporaso G, Lee K, Pal S. Cabozantinib (cabo) and nivolumab (nivo) with or without CBM588 in patients with metastatic renal cell carcinoma: Updated clinical outcomes of a phase I study. Journal Of Clinical Oncology 2025, 43: 543-543. DOI: 10.1200/jco.2025.43.5_suppl.543.Peer-Reviewed Original ResearchProgression-free survivalTreatment-related adverse eventsClinical benefitControl armTreatment armsFollow-upImproving progression-free survivalMedian progression-free survivalMetastatic renal cell carcinomaTime of data cutoffTarget lesion sizeTreatment naive patientsMedian Follow-UpPhase I studyKaplan-Meier methodSecondary clinical endpointsRenal cell carcinomaKarnofsky performance statusFisher's exact testMedian OSSarcomatoid featuresStable diseaseComplete responseData cutoffPapillary histologyEfficacy and toxicity profile of antibody-drug conjugate (ADC) based combination therapy in patients with advanced urothelial carcinoma (aUC): A systematic review of clinical trials.
Jaime-Casas S, Zugman M, Barragan-Carrillo R, Zang P, Ebrahimi H, Mercier B, Castro D, Yip W, Li X, Dizman N, Salgia N, Hsu J, Nguyen C, Chehrazi-Raffle A, Zengin Z, Meza L, Pal S, Tripathi A. Efficacy and toxicity profile of antibody-drug conjugate (ADC) based combination therapy in patients with advanced urothelial carcinoma (aUC): A systematic review of clinical trials. Journal Of Clinical Oncology 2025, 43: 813-813. DOI: 10.1200/jco.2025.43.5_suppl.813.Peer-Reviewed Original ResearchAny-grade adverse eventsAdvanced urothelial carcinomaObjective-response rateAntibody-drug conjugatesCombination regimensClinical trialsCheckpoint inhibitorsSafety/tolerability profileCombination therapyPublished prospective clinical trialsProspective clinical trialPeer-reviewed clinical trialsSystematic review of clinical trialsReview of clinical trialsRandom-effects modelEnfortumab vedotinSacituzumab govitecanUrothelial carcinomaProspective trialsTreatment landscapeMaculopapular rashEfficacy outcomesRetrospective studyToxicity profileCase report