Yiwei Xiong
Associate Research Scientist in Cell BiologyDownloadHi-Res Photo
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Cell Biology
Primary
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Associate Research Scientist in Cell Biology
Appointments
Cell Biology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Liverpool, Institute of Integrative Biology
- MSc
- Sun Yat-sen University, Pharmaceutical Sciences
- BS
- Sun Yat-sen University, Pharmaceutical Sciences
Research
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Overview
Medical Research Interests
Immunotherapy; Signal Transduction
ORCID
0000-0002-6205-4691- View Lab Website
Xiaolei Su Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yiwei Xiong's published research.
Research Interests
Research topics Yiwei Xiong is interested in exploring.
Xiaolei Su, PhD
Kazuki Sato, PhD
Longhui Zeng
Former YSMMaohan Su
Xinyan Zhang
Former YSM
Signal Transduction
Publications
2026
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine
Xiong Y, Tomares D, Guo J, Sato K, Zeng L, Tian Y, Su M, Albis A, Pant A, Pappu R, Su X. Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine. Nature Chemical Biology 2026, 22: 1120-1131. PMID: 41760814, PMCID: PMC13010460, DOI: 10.1038/s41589-026-02165-6.Peer-Reviewed Original ResearchThis study investigates how mast cell extracellular granules form via interactions between heparin and polyamines, creating unique microenvironments that enhance immune mediator activity.
2025
Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance
Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Kogure Y, Kataoka K, Ogawa S, Sondek J, Su X. Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance. EMBO Reports 2025, 26: 4563-4586. PMID: 40796680, PMCID: PMC12457681, DOI: 10.1038/s44319-025-00546-x.Peer-Reviewed Original ResearchCitations
2023
The physical landscape of CAR-T synapse
Xiong Y, Libby K, Su X. The physical landscape of CAR-T synapse. Biophysical Journal 2023, 123: 2199-2210. PMID: 37715447, PMCID: PMC11331049, DOI: 10.1016/j.bpj.2023.09.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2022
ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia
Xiong Y, Li Y, Cui X, Zhang L, Yang X, Liu H. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Cellular & Molecular Immunology 2022, 19: 898-912. PMID: 35637282, PMCID: PMC9149338, DOI: 10.1038/s41423-022-00881-2.Peer-Reviewed Original ResearchCitationsAltmetric
2021
ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages.
Yang N, Xiong Y, Wang Y, Yi Y, Zhu J, Ma F, Li J, Liu H. ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages. The Journal Of Immunology 2021, 206: 814-826. PMID: 33431658, DOI: 10.4049/jimmunol.2000569.Peer-Reviewed Original ResearchCitations
2020
T cell subset profile and inflammatory cytokine properties in the gut-associated lymphoid tissues of chickens during infectious bursal disease virus (IBDV) infection
Ruan Y, Wang Y, Guo Y, Xiong Y, Chen M, Zhao A, Liu H. T cell subset profile and inflammatory cytokine properties in the gut-associated lymphoid tissues of chickens during infectious bursal disease virus (IBDV) infection. Archives Of Virology 2020, 165: 2249-2258. PMID: 32696270, DOI: 10.1007/s00705-020-04735-y.Peer-Reviewed Original ResearchCitationsMeSH KeywordsAnimalsAntigens, CDB-Lymphocyte SubsetsBirnaviridae InfectionsBursa of FabriciusCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChickensCTLA-4 AntigenGene Expression RegulationInfectious bursal disease virusInterferon-betaInterferon-gammaInterleukin-10Intestinal MucosaLymphocyte Activation Gene 3 ProteinPalatine TonsilPoultry Diseases
2019
Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells.
Xiong Y, Yi Y, Wang Y, Yang N, Rudd C, Liu H. Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells. The Journal Of Immunology 2019, 203: 3023-3036. PMID: 31666306, DOI: 10.4049/jimmunol.1900556.Peer-Reviewed Original ResearchCitations
2018
STAU1 binds to IBDV genomic double‐stranded RNA and promotes viral replication via attenuation of MDA5‐dependent β interferon induction
Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, Chen M, Luan S, Zhang E, Liu H. STAU1 binds to IBDV genomic double‐stranded RNA and promotes viral replication via attenuation of MDA5‐dependent β interferon induction. The FASEB Journal 2018, 33: 286-300. PMID: 29979632, DOI: 10.1096/fj.201800062rr.Peer-Reviewed Original ResearchCitations
2017
Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion
Xiong Y, Ye C, Yang N, Li M, Liu H. Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. The Journal Of Immunology 2017, 199: 4142-4154. PMID: 29127148, DOI: 10.4049/jimmunol.1700572.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsApoptosis Regulatory ProteinsCell AdhesionCell MembraneChlorocebus aethiopsCOS CellsEnzyme ActivationGene Knockdown TechniquesHumansIntegrinsJurkat CellsLymphocyte Function-Associated Antigen-1MiceModels, ImmunologicalMonomeric GTP-Binding ProteinsPhosphoproteinsPhosphorylationProtein BindingProtein Processing, Post-Translationalrac1 GTP-Binding Proteinrap1 GTP-Binding ProteinsReceptors, Antigen, T-CellRecombinant Fusion ProteinsRNA, Small InterferingSignal TransductionT-LymphocytesUbiquitin-Conjugating Enzyme UBC9Ubiquitin-Conjugating Enzymes
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