Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsSummer L Thompson, PhD, MS
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Titles
Assistant Professor Adjunct in Psychiatry
Biography
Dr. Thompson’s research investigates integrative mechanisms underlying environmental influences on reward-related behaviors that are altered in neuropsychiatric conditions. She earned her PhD in 2017 in Neurobiology from the University Chicago, where she trained under Dr. Stephanie Dulawa. Her graduate work used models of compulsive-like behavior to investigate mechanisms and therapeutic targets. She received a travel award for this work. She then accepted a postdoctoral position in the laboratory of Dr. Jane Taylor in the Department of Psychiatry at Yale University where she received training in operant and computational modeling approaches for the study of reward-driven behaviors that are altered in neuropsychiatric conditions including compulsive disorders and alcohol use.
In 2021, Dr. Thompson was promoted to Associate Research Scientist at Yale. She was then awarded a pathway to independence career development award from NIAAA (K99/R00) to study the role of the gut microbiota in alcohol use behaviors and decision making under the co-mentorship of Dr. Taylor and Dr. Noah Palm (Department of Immunobiology). She has received several additional awards for her work, including pilot awards from the Center for the Translational Neuroscience of Alcoholism and from the Yale/NIDA Neuroproteomics Core. Her ongoing and future research focus on the mediating role of the gut in environmental influences on reward-driven behaviors by integrating sophisticated behavioral paradigms, computational modeling and statistical analyses, and multi-organ molecular biology techniques including "omics" and bioinformatics.
Appointments
Psychiatry
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- The University of Chicago, Neurobiology (2017)
- Visiting Graduate Student
- University of California San Diego (2017)
- MS
- The University of Chicago, Molecular Pathogenesis and Molecular Medicine (2014)
- BA
- Pomona College, Neuroscience (2011)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-1922-1201
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Jane Rebecca Taylor, PhD
Stephanie Groman, PhD
Ethan Foscue
John Krystal, MD
Ralph DiLeone, PhD
Alexa-Nicole Leverington
Compulsive Behavior
Decision Making
Publications
Featured Publications
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchCitationsAltmetricKetogenic diet enhances the effects of oxycodone in mice
Trinko R, Diaz D, Foscue E, Thompson S, Taylor J, DiLeone R. Ketogenic diet enhances the effects of oxycodone in mice. Scientific Reports 2023, 13: 7507. PMID: 37160959, PMCID: PMC10170077, DOI: 10.1038/s41598-023-33458-8.Peer-Reviewed Original ResearchCitationsAltmetricReinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling
Huang G, Thompson SL, Taylor JR. MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling. Alcohol Clinical And Experimental Research 2021, 45: 732-742. PMID: 33587295, PMCID: PMC8076072, DOI: 10.1111/acer.14576.Peer-Reviewed Original ResearchCitationsMeSH KeywordsAnimalsBinge DrinkingDose-Response Relationship, DrugDrug Evaluation, PreclinicalExcitatory Amino Acid AntagonistsFemaleHomer Scaffolding ProteinsMaleMAP Kinase Signaling SystemMice, Inbred C57BLMitogen-Activated Protein Kinase 1Nucleus AccumbensPyridinesReceptor, Metabotropic Glutamate 5Septal NucleiSex CharacteristicsKetamine induces immediate and delayed alterations of OCD-like behavior
Thompson SL, Welch AC, Iourinets J, Dulawa SC. Ketamine induces immediate and delayed alterations of OCD-like behavior. Psychopharmacology 2020, 237: 627-638. PMID: 31927606, DOI: 10.1007/s00213-019-05397-8.Peer-Reviewed Original ResearchCitationsAltmetricBtbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchCitationsAltmetricDissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice
Thompson SL, Dulawa SC. Dissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice. PLOS ONE 2019, 14: e0211239. PMID: 30721232, PMCID: PMC6363181, DOI: 10.1371/journal.pone.0211239.Peer-Reviewed Original ResearchCitations
2026
Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder
Lee C, Hwang A, McRiley D, Lee J, Thibodeau G, Duman C, Zhang X, Skarica M, Coudriet J, Xu S, Terwilliger R, Sliby A, Wang J, Nguyen T, Liu Y, Li H, Dai Y, Duan Z, Lei Y, Lin Y, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Xu K, Zhou H, Zhao H, Thompson S, Krystal J, Che A, Taylor J, Zhang J, Girgenti M. Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder. Nature Communications 2026, 17: 1634. PMID: 41554730, PMCID: PMC12905162, DOI: 10.1038/s41467-026-68351-1.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Effects of alcohol use on the gut, inflammation, and organ injury: A summary of the 2025 Alcohol and Immunology Research Interest Group (AIRIG) meeting
Tschann M, Brown J, Thompson S, Kumari A, Peer A, Mandrekar P, Romesh N, Hwang C, Yeligar S, Kovacs E, Choudhry M. Effects of alcohol use on the gut, inflammation, and organ injury: A summary of the 2025 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 2025, 130: 28-32. PMID: 41274585, PMCID: PMC13112174, DOI: 10.1016/j.alcohol.2025.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2024
Xylazine induces dopamine release and augments the effects of fentanyl
Trinko J, Foscue E, Kong E, Basu A, Corstens A, Thompson S, Kaye A, Taylor J, DiLeone R. Xylazine induces dopamine release and augments the effects of fentanyl. Journal Of Clinical Investigation 2024, 134: e183354. PMID: 39545408, PMCID: PMC11563672, DOI: 10.1172/jci183354.Peer-Reviewed Original ResearchCitationsAltmetric
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