Shaili Gupta, MBBS
Cards
Appointments
Titles
Director of Diversity, Equity and Inclusivity, GME, VA; Associate Program Director, Internal Medicine Residency Program, Department of Medicine; Vice-Chair of DEI at VACHS, Veterans Affairs Healthcare System of CT
Contact Info
General Internal Medicine
950 Campbell Avenue, Bldg 1, Floor 5, Department of Medicine
West Haven, CT 06516
United States
Appointments
Titles
Director of Diversity, Equity and Inclusivity, GME, VA; Associate Program Director, Internal Medicine Residency Program, Department of Medicine; Vice-Chair of DEI at VACHS, Veterans Affairs Healthcare System of CT
Contact Info
General Internal Medicine
950 Campbell Avenue, Bldg 1, Floor 5, Department of Medicine
West Haven, CT 06516
United States
Appointments
Titles
Director of Diversity, Equity and Inclusivity, GME, VA; Associate Program Director, Internal Medicine Residency Program, Department of Medicine; Vice-Chair of DEI at VACHS, Veterans Affairs Healthcare System of CT
Contact Info
General Internal Medicine
950 Campbell Avenue, Bldg 1, Floor 5, Department of Medicine
West Haven, CT 06516
United States
About
Titles
Associate Professor of Medicine (General Medicine)
Director of Diversity, Equity and Inclusivity, GME, VA; Associate Program Director, Internal Medicine Residency Program, Department of Medicine; Vice-Chair of DEI at VACHS, Veterans Affairs Healthcare System of CTBiography
Dr Gupta is a clinician-educator with expertise in clinical virology, and diversity, equity and inclusion in healthcare education. Her primary interests are in clinical research, medical education, and enhancement of equity for learners, faculty, as well as patients. She is an Associate Program Director for Yale Internal Medicine residency program, and Vice-Chair and Director of DEI at VA Connecticut. She is faculty leader for the Race, Bias and Advocacy in Medicine, a Distinction Pathway track in Internal Medicine Residency Program. Dr. Gupta has been serving as research supervisor, thesis advisor and mentor to students, residents, fellows and faculty for more than a decade, and is passionate about career development for her mentees. She completed her fellowship training at Yale in 2008, and currently divides her time between providing patient care for veterans admitted to the VA hospital, education for trainees, administrative efforts for DEI enhancement, and clinical research.
Appointments
General Internal Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
- General Internal Medicine
- Internal Medicine
- Orange College Affiliates
Education & Training
- Fellowship
- Yale University School of Medicine (2008)
- Residency
- University of Maryland, Union Memorial Hospital (2006)
- MBBS
- Sawai Man Singh Medical College (1998)
Board Certifications
Infectious Diseases
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2018
- Original Certification Date
- 2008
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2016
- Original Certification Date
- 2006
Research
Overview
Dr. Gupta has extensive experience in viral variants and mutations that impact clinical outcomes of viral diseases. Her research work has ranged from investigation of minority resistant variants of HIV and the management of treatment-experienced HIV+ individuals, to evaluation of clinical outcomes among multidrug resistant HIV+ individuals, patients co-infected with HIV and viral Hepatitis, and individuals with bacterial pyogenic arthritis. She has written on rapid diagnostic platforms for bloodstream infections, and has been conducting research on DEI-related perceptions in healthcare settings. Since the onset of COVID-19 pandemic, her research has been focused on evaluating genomic and immunological interplay of SARS-CoV-2. She has been conducting epidemiologic and outcomes analyses on veterans diagnosed with COVID-19 across the six New England states through her active clinical and virologic repository, including dynamic evaluation of SARS-CoV-2 variants. She has also been conducting research into the clinical and demographic correlations of vaccine-generated immune responses.
Research at a Glance
Yale Co-Authors
Publications Timeline
Naseema Merchant, FCCP, FACP, FHM, MBBS
Craig Gunderson, MD, SFHM
Sheldon Campbell, MD, PhD
Louise-Marie Dembry, MD, FACP, MS, MBA, FIDSA, BS
Tassos C. Kyriakides, PhD
Chantal Vogels, PhD
Publications
2022
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)
Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell responsesAnti-spike IgGVisit 3SARS-CoV-2Older PWHVisit 2Immune responseSingle-center longitudinal observational studyVirus-specific T cell responsesVaccine-induced humoral immunityLong-term protective immunityT cell immune responsesOlder peopleMedian age 61RBD IgG levelsPrimary study outcomeCOVID-19 vaccinationImmune response evaluationLongitudinal observational studyCOVID-19 vaccineWilcoxon signed-rank testBNT162b2 boosterBNT162b2 vaccinationCD8 responsesDetectable CD4Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population
Zhao M, Slotkin R, Sheth AH, Pischel L, Kyriakides TC, Emu B, McNamara C, Shi Q, Delgobbo J, Xu J, Marhoffer E, Mercer-Falkoff A, Holleck J, Ardito D, Sutton RE, Gupta S. Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population. Clinical Infectious Diseases 2022, 76: e391-e399. PMID: 35639598, PMCID: PMC9278145, DOI: 10.1093/cid/ciac416.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMonth postboosterRNA vaccinationClinical variablesNeutralization responseEnd-stage renal diseaseBooster dose responsePrimary series vaccinationPrimary vaccine seriesMultiple clinical factorsSystemic steroid useDoses of vaccinePrior COVID-19Maximal inhibitory concentration valuesHalf maximal inhibitory concentration (IC50) valuesSeries vaccinationVaccine seriesVaccine regimensClinical factorsDiabetes mellitusRenal diseaseComorbid conditionsSteroid useCOVID infectionImmune responseUS populationDevelopment of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2
Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2. Cell Reports Methods 2022, 2: 100252. PMID: 35757815, PMCID: PMC9213030, DOI: 10.1016/j.crmeth.2022.100252.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-spike monoclonal antibodiesTransmission assaysTherapeutic antiviral drugsSARS-CoV-2Quantitative readoutVirus-cell bindingRapid quantificationConvalescent seraNeutralization assaysAntiviral drugsResearch reagentsSmall molecule drugsClinical settingViral replicationPseudotyped particlesMonoclonal antibodiesLaboratory equipmentQuantitative assayClinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states
Lee M, Cosentino D, Kyriakides TC, Cavallaro T, Stack G, Gupta S. Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states. Journal Of Hospital Medicine 2022, 17: 534-538. PMID: 35661577, PMCID: PMC9348310, DOI: 10.1002/jhm.12852.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCOVID-19Intensive care unit admissionVeterans Administration Healthcare SystemCare unit admissionNonpsychiatric hospitalizationsVirologic factorsFull vaccinationUnit admissionICU careClinical outcomesPoor outcomeMean ageRetrospective analysisD614G mutationHealthcare systemVeteransNew England statesHospitalizationOlder cohortOutcomesViral epidemiologyVaccinationDemographic factorsG mutationAgePancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites
Ilagan-Ying YC, Park EY, Lam R, Gupta S. Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites. Journal Of General Internal Medicine 2022, 37: 2082-2085. PMID: 35260958, PMCID: PMC9198176, DOI: 10.1007/s11606-022-07463-y.Peer-Reviewed Original ResearchCitationsAltmetric
2021
COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective Analysis
Lee M, Sallah YH, Petrone M, Ringer M, Cosentino D, Vogels CBF, Fauver JR, Alpert TD, Grubaugh ND, Gupta S. COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective Analysis. JMIRx Med 2021, 2: e31503. PMID: 35014989, PMCID: PMC8722526, DOI: 10.2196/31503.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSARS-CoV-2 infectionPeak disease severityCOVID-19 outcomesChart reviewMean ageDisease severityHigher comorbidity burdenRetrospective chart reviewSARS-CoV-2 RNACohort of veteransGeneral US populationNon-white raceCOVID-19 infectionManual chart reviewSARS-CoV-2Multivariate regression analysisO2 requirementsNon-white veteransSARS-CoV-2 lineagesComorbidity burdenVirologic factorsD614G substitutionMultiple SARS-CoV-2 lineagesVirologic characteristicsClinical outcomesFalling Through the Cracks
Gupta S, Klebanoff MJ, Pathak A, Unaka NI, Herbst B. Falling Through the Cracks. Journal Of Hospital Medicine 2021, 16: 694-698. PMID: 34328836, DOI: 10.12788/jhm.3578.Peer-Reviewed Original ResearchAltmetric
2020
Advances in rapid diagnostics for bloodstream infections
Briggs N, Campbell S, Gupta S. Advances in rapid diagnostics for bloodstream infections. Diagnostic Microbiology And Infectious Disease 2020, 99: 115219. PMID: 33059201, DOI: 10.1016/j.diagmicrobio.2020.115219.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsSARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent?
Federman DG, Gupta S, Stack G, Campbell SM, Peaper DR, Dembry LM, Fisher A, Tarabar AF, Kozal M, Ruser CB. SARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent? PLOS ONE 2020, 15: e0237127. PMID: 32756602, PMCID: PMC7406068, DOI: 10.1371/journal.pone.0237127.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMRSA swabsViral swabSARS-CoV-2 PCR testingCopan ESwabSevere acute respiratory syndromeMRSA nasal swabSARS-CoV-2 assayAcute respiratory syndromeCOVID-19SARS-CoV-2SARS-CoV-2 detectionNasopharyngeal swabsCoronavirus 2Nasal swabsRespiratory syndromePCR testingSwab collectionSwabsSwab samplesCepheid Xpert XpressXpert XpressWidespread testingCollection kitHealthcare systemViral mediaHospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System
Gupta S, Federman DG. Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System. Postgraduate Medicine 2020, 132: 489-494. PMID: 32331509, PMCID: PMC7212542, DOI: 10.1080/00325481.2020.1761668.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVeterans Affairs Connecticut Healthcare SystemPandemic coronavirus disease 2019Healthcare systemCoronavirus disease 2019Department of MedicineSurge of patientsMore patientsHealthcare workersDisease 2019Hospital preparednessEpidemiologic predictionsPandemic preparednessHospital systemCOVID-19PatientsCOVID-19 pandemicPandemicHospitalPreparednessCare
Academic Achievements and Community Involvement
activity Member
Peer Review Groups and Grant Study SectionsVeterans Affairs Healthcare SystemsDetails2012 - PresentDescriptionHuman Investigation Committee, VACT, West Haven, CTactivity Member
CommitteesVeterans Affairs Healthcare SystemsDetails2015 - PresentDescriptionAntibiotic Stewardship Committee at VACT, West Haven, CTactivity Co-Chair
CommitteesYale Internal Medicine Program Evaluation CommitteeDetails2015 - Presentactivity Reviewer
Journal ServicePlos OneDetails2018 - Presentactivity Reviewer
Journal ServiceAnnals of Internal MedicineDetails2019 - Present
Links & Media
News
- March 15, 2024
Announcing the New Residents in the Yale-Waterbury Internal Medicine Residency Program!
- March 15, 2024
Announcing the Incoming Residents in the Internal Medicine Traditional Residency Program!
- December 13, 2023
New Web App for COVID-19 Immune Antibody to Help Guide Vaccine Uptake and Timing
- November 20, 2023
Fellow Focus in Four: Neima Briggs, MD, PhD, Infectious Diseases
Get In Touch
Contacts
General Internal Medicine
950 Campbell Avenue, Bldg 1, Floor 5, Department of Medicine
West Haven, CT 06516
United States
Events
Yale Only Shaili Gupta, MBBS - Benjamin Mba, MBBS