Santiago Clocchiatti-Tuozzo, MD, MHS
About
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Titles
Hospital Resident
Biography
Santiago Clocchiatti-Tuozzo, MD, MHS, is a Neurology Resident at Yale New Haven Hospital. He completed his medical degree at the University of Buenos Aires and a Master of Health Science in Bioinformatics at Yale. Before residency, he was a T32 Postdoctoral Fellow in Geriatric Clinical Epidemiology and Aging-Related Research in the Department of Neurology at Yale.
Dr. Clocchiatti-Tuozzo’s research lies at the intersection of neurology, aging, and data science, with a focus on genetic epidemiology and bioinformatics. His work explores how genetic variation and related phenotypes—such as cardiovascular and neurological risk factors—shape brain health and aging-related outcomes, including dementia and cognitive decline, besides vascular-related outcomes, like ischemic stroke, cerebral small vessel disease, and intracerebral hemorrhage. A central emphasis of his research is understanding heterogeneity of treatment effects and pharmacological responses in neurological disease. He integrates multiple data sources, including genomic datasets, neuroimaging, electronic health records, and other -omics technologies, to advance precision medicine approaches in neurology.
Departments & Organizations
Education & Training
- MHS
- Yale School of Public Health, Bioinformatics (2024)
- MD
- University of Buenos Aires (2021)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-5377-434X- View Lab Website
Falcone Labs
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Cyprien Rivier, MD, MSc
Guido J. Falcone, MD, ScD, MPH
Kevin Sheth, MD
Shufan Huo, MD, PhD
Daniela Brenda Renedo, MD
Adam de Havenon, MD, MSCI
Stroke
Dementia
Publications
Featured Publications
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionBrain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, PMCID: PMC11760050, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessmentAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseAPOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation
Renedo D, Rivier C, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Wu K, Torres-Lopez V, Huo S, Gunel M, de Havenon A, Sheth K, Matouk C, Falcone G. APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation. JAMA Network Open 2024, 7: e2355368. PMID: 38363572, PMCID: PMC10873768, DOI: 10.1001/jamanetworkopen.2023.55368.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApolipoprotein E e4Participants of European ancestryRisk of intracerebral hemorrhageHigh risk of intracerebral hemorrhageCross-sectional studyUK BiobankEuropean ancestryHigh riskUs Research ProgramUK Biobank participantsInternational Classification of DiseasesAssociated with higher risk of ICHCross-sectional study of patientsAPOE e4 statusClassification of diseasesApolipoprotein ENinth Revision and Tenth RevisionAssociated with higher riskIndividual-level dataMultivariate logistic regressionIntracerebral hemorrhage riskBrain arteriovenous malformationsIntracerebral hemorrhageBiobank participantsTenth RevisionThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete data
2025
Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts
de Havenon A, Littig L, Clocchiatti‐Tuozzo S, Johnson I, Constantinescu S, Rivier C, Huo S, Kimberly W, Gomez‐Isla T, Kim Y, Stulberg E, Smith E, Rosand J, Falcone G, Sheth K, Brickman A. Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts. Annals Of Neurology 2025 PMID: 41267647, DOI: 10.1002/ana.78103.Peer-Reviewed Original ResearchAltmetricConceptsIncident all-cause dementiaDementia incidence ratesAll-cause dementiaApolipoprotein E e4 statusE4 statusHazard ratioRisk of incident all-cause dementiaRisk of incident dementiaWhite matter hyperintensitiesIncidence rateVascular risk managementDelay dementia onsetAdjusted hazard ratiosProspective cohort studyEffects of white matter hyperintensityApolipoprotein EAt-risk individualsCox proportional hazards modelsIncident dementiaDementia riskDementia onsetProportional hazards modelWhite matter hyperintensities burdensAtherosclerosis RiskARICSLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study.
Renedo D, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Huo S, Acosta J, Hebert R, Gunel M, Sansing L, Sheth K, Falcone G, Matouk C, Rivier C. SLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study. Stroke 2025 PMID: 41221640, DOI: 10.1161/strokeaha.125.052604.Peer-Reviewed Original ResearchAltmetricConceptsMendelian randomizationSubarachnoid hemorrhage riskIncident SAH casesNontraumatic subarachnoid hemorrhageSubarachnoid hemorrhageUK BiobankSmoking statusClinical priorityPrevention strategiesCellular expression profilesCox proportional hazards analysisProportional hazards analysisRisk predictionCis-protein quantitative trait lociCD4 naive cellsSAH casesRisk biomarkersSubarachnoid hemorrhage pathophysiologyAdaptive immune responsesHuman hematopoietic progenitorsFollow-upQuantitative trait lociSingle-cell transcriptome analysisRiskCerebrovascular eventsDifferential results of genetic risk scoring for multiple sclerosis in European and African American populations
Rivier C, Xu L, Clocchiatti-Tuozzo S, Zhao H, Ohno-Machado L, Hafler D, Falcone G, Longbrake E. Differential results of genetic risk scoring for multiple sclerosis in European and African American populations. Multiple Sclerosis Journal 2025, 31: 1304-1313. PMID: 40991630, PMCID: PMC12633797, DOI: 10.1177/13524585251377607.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsGenetic risk scoreInternational ClassificationSystematized Nomenclature of MedicineAfrican ancestryRisk scoreCross-sectional studyHigh-risk individualsMultiple sclerosisSystematized NomenclatureAfrican American populationAfrican ancestry groupMS prevalenceAncestry groupsMS riskNomenclature of MedicineAmerican populationParticipantsAfrican participantsAncestryEuropean populationsClinical trialsDifferentiation resultsScoresIndividualsPopulationCharacterizing Stroke Clots Using Single‐Cell Sequencing
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single‐Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha/2025/041738-t. PMID: 40878981, PMCID: PMC12553457, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion strokePolygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program
Huo S, Rivier C, Clocchiatti‐Tuozzo S, Renedo D, Petersen N, de Havenon A, Meeker D, Zhao H, Ohno‐Machado L, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program. Annals Of Neurology 2025 PMID: 40827941, DOI: 10.1002/ana.78009.Peer-Reviewed Original ResearchCitationsAltmetricConceptsUs Research ProgramUncontrolled hypertensionSystolic BPGenetic riskSusceptibility to hypertensionRates of uncontrolled hypertensionPolygenic risk scoresAssociated with higher systolic BPOdds of uncontrolled hypertensionCox proportional hazards regressionUnited Kingdom BiobankGenetic association studiesHigh-risk individualsHigher systolic BPProportional hazards regressionBlood pressure treatmentIncident strokeStroke hazardBlood pressureHigher RatesSystolic blood pressureHypertensive adultsDiagnosed hypertensionBP medicationsHazards regression
Academic Achievements & Community Involvement
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Activities
activity American Heart Association
08/24/2022 - PresentProfessional OrganizationsMemberactivity American Academy of Neurology
2022 - PresentProfessional OrganizationsMemberactivity American Geriatrics Society
11/30/2022 - PresentProfessional OrganizationsMemberactivity Gerontological Society of America
06/15/2023 - PresentProfessional OrganizationsMemberactivity Stroke, American Heart Association
2023 - PresentJournal ServiceReviewer
Honors
honor Futures in Neurologic Research Scholarship
04/13/2024National AwardAmerican Academy of Neurology (AAN)DetailsUnited Stateshonor Junior Investigator Travel Grant, International Stroke Conference
02/07/2024National AwardAmerican Heart AssociationDetailsUnited Stateshonor Butler-Williams Scholars Program
08/23/2023National AwardNational Institute on Aging (NIA), National Institutes of Health (NIH).DetailsUnited Stateshonor Bernard J. Tyson Career Development Award and Underrepresented Racial and Ethnic Groups Travel Grant
02/08/2023National AwardAmerican Heart AssociationDetailsUnited Stateshonor HEADS-UP: Health Equity and Actionable Disparities in Stroke Travel Award
02/08/2023National AwardAmerican Heart AssociationDetailsUnited States
News & Links
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News
- August 21, 2025
Study Ties Genetics and Common Anticoagulant to Risk of Intracranial Hemorrhage
- June 13, 2024Source: MedPage Today
APOE Genotypes and Dementia
- May 07, 2024
Santiago Clocchiatti-Tuozzo, MD, Wins 2024 Futures in Neurologic Research Scholarship
- January 29, 2024
Poor Sleep May Increase Markers of Poor Brain Health, New Study Finds
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