Sandeep Kumar Mishra, PhD
Associate Research ScientistDownloadHi-Res Photo
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Magnetic Resonance Research Center
300 Cedar Street, The Anlyan Center (TAC) N147
New Haven, CT 06519
United States
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Titles
Associate Research Scientist
Appointments
Radiology & Biomedical Imaging
Associate Research ScientistPrimary
Other Departments & Organizations
- Bioimaging Sciences
- Magnetic Resonance Research Center
- Magnetic Resonance Spectroscopy
- Radiology & Biomedical Imaging
Education & Training
- Postdoctoral Associate
- Yale University (2024)
- PhD
- Pondicherry University (2017)
Research
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Overview
Medical Research Interests
Carcinoma, Hepatocellular; Contrast Media; Glioblastoma; Macrocyclic Compounds; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Stroke
ORCID
0000-0002-1016-0206
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sandeep Kumar Mishra's published research.
Publications Timeline
A big-picture view of Sandeep Kumar Mishra's research output by year.
Research Interests
Research topics Sandeep Kumar Mishra is interested in exploring.
Daniel Coman, PhD
D. S. Fahmeed Hyder, PhD
Justus Verhagen, PhD
Peter Herman, MD, PhD
Basavaraju G. Sanganahalli, PhD
Hal Blumenfeld, MD, PhD
31Publications
655Citations
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Contrast Media
Carcinoma, Hepatocellular
Publications
2025
Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging
Herman P, Sanggaard S, James S, Akif A, Mishra S, Sanganahalli B, Verhagen J, Blumenfeld H, Hyder F. Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging. Cerebral Cortex 2025, 35: bhaf165. PMID: 40624899, DOI: 10.1093/cercor/bhaf165.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCerebral blood volumeNeuronal activityNeurometabolic couplingAlterations of neuronal activityNeurovascular couplingImaging of metabolic activityCerebral blood volume changesBolus injectionGlucose uptakeMultimodal optical imagingBlood volumeCalcium indicatorNear-infrared spectroscopyOptical imagingSimultaneous imagingBlood volume changesNear-infrared spectroscopy recordingsTraumatic brain injuryBrain injuryMultiplexed optical imagingGlucose analogMetabolic activityGECIsOptical systemCa2Transmembrane pH imaging distinguishes glycolytic and oxidative phenotypes in gliomas
Coman D, Mishra S, Kurdi S, Santana J, Hyder F. Transmembrane pH imaging distinguishes glycolytic and oxidative phenotypes in gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3064.Peer-Reviewed Original ResearchTransition metal based phosphonated macrocyclics for pH biosensing
Mishra S, Kurdi S, Coman D, Hyder F. Transition metal based phosphonated macrocyclics for pH biosensing. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3861.Peer-Reviewed Original ResearchConceptsSorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation rate
2024
Complexes of Iron(II), Cobalt(II), and Nickel(II) with DOTA-Tetraglycinate for pH and Temperature Imaging Using Hyperfine Shifts of an Amide Moiety
Mishra S, Zakaria A, Mihailovic J, Maritim S, Mercado B, Coman D, Hyder F. Complexes of Iron(II), Cobalt(II), and Nickel(II) with DOTA-Tetraglycinate for pH and Temperature Imaging Using Hyperfine Shifts of an Amide Moiety. Inorganic Chemistry 2024, 63: 22559-22571. PMID: 39533962, DOI: 10.1021/acs.inorgchem.4c04023.Peer-Reviewed Original ResearchCitationsAltmetricConceptsParamagnetic complexesDivalent transition-metal ionsNitrogen donor atomsLanthanide metal ionsComplexes of iron(IITransition-metal ionsChemical exchange saturation transferDonor atomsAmide moietyCrystallographic dataCoordination numberHyperfine shiftsMetal ionsPH sensitivityMoietyProtonIonsLow cytotoxicityPH imagingSaturation transferMagnetic resonanceCobalt(IINickel(IIIron(IILanthanideEditorial: Engineered medicines to mitigate resistance to cancer immunotherapy
Ranjan K, Dube P, Mishra S. Editorial: Engineered medicines to mitigate resistance to cancer immunotherapy. Frontiers In Medicine 2024, 11: 1452812. PMID: 39165370, PMCID: PMC11333442, DOI: 10.3389/fmed.2024.1452812.Peer-Reviewed Original ResearchAltmetricFe(II), Co(II) and Ni(II) complexed DOTA-tetraglycinates as pH and temperature biosensors
Mishra S, Zakaria A, Mihailovic J, Maritim S, Coman D, Hyder F. Fe(II), Co(II) and Ni(II) complexed DOTA-tetraglycinates as pH and temperature biosensors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3207.Peer-Reviewed Original ResearchEffect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell infiltrationCD8+ T cellsMatrix metalloproteinase inhibitionT cellsHepatocellular carcinomaMatrix metalloproteinase inhibitorsMatrix metalloproteinasesResidual tumorCXCR3+ CD8+ T cellsCytotoxic CD8+ T cell infiltrationIntratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8+ T cell infiltrationMouse model of hepatocellular carcinomaEarly-stage hepatocellular carcinomaImage-guided tumor ablationUnpaired Student's t testModel of hepatocellular carcinomaFirst-line therapyMurine hepatocellular carcinomaT cell subsetsTumor-associated macrophagesMurine HCC modelLocal immune responseFemale BALB/c miceTransmembrane pH gradient imaging in rodent glioma models
Mishra S, Santana J, Mihailovic J, Hyder F, Coman D. Transmembrane pH gradient imaging in rodent glioma models. NMR In Biomedicine 2024, 37: e5102. PMID: 38263680, PMCID: PMC10987279, DOI: 10.1002/nbm.5102.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNormal tissuesRodent glioma modelsGL261 gliomasU87 gliomasTumor microenvironmentPotential therapeutic targetGlioma modelTumor survivalExtracellular acidosisTumorMetabolic reprogrammingRegulate drug deliveryIntracellular pHRat brainExtracellular pHTherapeutic targetGliomaMouse brainDrug deliveryIntracellular milieuTransmembrane pH gradientBrainSubmillimeter resolutionTissueCells
2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic waste
Academic Achievements & Community Involvement
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activity Dean's Faculty Advisory Council (FAC) Rep
11/01/2024 - PresentCommitteesAd-hoc MemberDetailsAs an elected member of the Faculty Advisory Council (FAC) at Yale School of Medicine, Sandeep serves as a vital conduit between faculty and the Dean’s office. His role involves attending regularly scheduled meetings with YSM administration to discuss new ideas and address faculty concerns. Representing his department, Sandeep actively engages with colleagues to understand their perspectives, advocate for their needs, and communicate key updates from the FAC. Through this role, he contributes to fostering a collaborative environment, ensuring that faculty voices are heard, and driving initiatives that enhance the academic, professional, and institutional goals of Yale School of Medicine.
Activities
activity Frontiers in Imaging
07/01/2025 - PresentJournal ServiceAssociate Editoractivity Frontiers in Medicine
07/01/2023 - PresentJournal ServiceGuest Editoractivity World Molecular Imaging Society
2021 - PresentProfessional OrganizationsAbstract Revieweractivity The International Society for Magnetic Resonance in Medicine
2023 - PresentProfessional OrganizationsAbstract Reviewer
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- February 28, 2024
YCC Research Publications
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Magnetic Resonance Research Center
300 Cedar Street, The Anlyan Center (TAC) N147
New Haven, CT 06519
United States