Meghan Van Zandt
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2026
PIP4K2A/2B inhibitor suppresses tumor growth in a xenograft model of NSCLC
He Z, Chen S, Bosenberg M, Muthusamy V, Xi Y, Wang H, Micheli F, Cianciulli A, Beato C, Van Zandt M, Ellman J, Ha Y. PIP4K2A/2B inhibitor suppresses tumor growth in a xenograft model of NSCLC. IScience 2026, 29: 115952. PMID: 42205699, PMCID: PMC13206749, DOI: 10.1016/j.isci.2026.115952.Peer-Reviewed Original Research
2025
Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
Baro M, Lee H, Kelley V, Lou R, Phoomak C, Politi K, Zeiss C, Van Zandt M, Contessa J. Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation. Cell Chemical Biology 2025, 32: 839-853.e6. PMID: 40494352, PMCID: PMC13107401, DOI: 10.1016/j.chembiol.2025.05.005.Peer-Reviewed Original ResearchMolecular insights into de novo small-molecule recognition by an intron RNA structure
Liu T, Xu L, Chung K, Sisto L, Hwang J, Zhang C, Van Zandt M, Pyle A. Molecular insights into de novo small-molecule recognition by an intron RNA structure. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502425122. PMID: 40339124, PMCID: PMC12088405, DOI: 10.1073/pnas.2502425122.Peer-Reviewed Original ResearchNovel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns
Fedorova O, Luo M, Jagdmann G, Van Zandt M, Sisto L, Pyle A. Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. ACS Chemical Biology 2025, 20: 378-385. PMID: 39824511, PMCID: PMC11851433, DOI: 10.1021/acschembio.4c00631.Peer-Reviewed Original Research
2022
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity
Li J, Chen L, Billedeau R, Stanton T, Chiang J, Lee C, Li W, Steggerda S, Emberley E, Gross M, Bhupathi D, Che X, Chen J, Dang R, Huang T, Ma Y, MacKinnon A, Makkouk A, Marguier G, Neou S, Sotirovska N, Spurlock S, Zhang J, Zhang W, van Zandt M, Yuan L, Savoy J, Parlati F, Sjogren E. Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity. Journal Of Medicinal Chemistry 2022, 66: 345-370. PMID: 36529947, DOI: 10.1021/acs.jmedchem.2c01287.Peer-Reviewed Original Research