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Manisha Juthani, MD

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Professor of Medicine (Infectious Diseases)

Titles

Professor, Epidemiology of Microbial Diseases

About

Titles

Professor of Medicine (Infectious Diseases)

Professor, Epidemiology of Microbial Diseases

Biography

Dr. Juthani is a Professor of Medicine and an Infectious Diseases physician at Yale School of Medicine. She completed her undergraduate training at the University of Pennsylvania, attended Cornell University Medical College, completed residency training at New York-Presbyterian Hospital/Weill Cornell Campus, and was a Chief Resident at Memorial-Sloan Kettering Cancer Center. She arrived at Yale School of Medicine in 2002 for Infectious Diseases Fellowship Training and joined the full-time faculty in 2006. She assumed the role of Infectious Diseases Fellowship Program Director in 2012. During the COVID-19 pandemic, she has been instrumental in leading the ID efforts at Yale School of Medicine and Yale New Haven Hospital. Her federally funded research focused on infections in older adults, specifically urinary tract infections and pneumonia. Most notably, she was the Principal Investigator of an R01-funded research project that resulted in the 2016 JAMA publication entitled, “Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial.” This publication received widespread attention in the lay press, including The New York Times and CNN to name a few, and achieved an Almetric Attention Score of 1546, placing it in the top 5% of all research outputs scored by Altmetric. In December 2016, The New Yorker identified this research as one of the most notable medical findings of 2016, and Dr. Juthani was interviewed and featured in the GeriPal and Gastropod podcasts. Additionally, in her parallel work with pneumonia prevention, she was the first author on the 2015 Clinical Infectious Diseases publication entitled, “A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders.” In addition to her academic responsibilities, Dr. Juthani enjoys talking and writing about medical topics in the lay press. During the COVID-19 pandemic, she has been featured on CNN, WTNH, ABC's 20/20, CT Public Radio/NPR, BBC's News Hour, The Wall Street Journal, The New York Times, USA Today, and CGTN. Her written pieces have been featured in The Boston Globe, The Huffington Post, Pacific Standard, and Next Avenue. Her most recent area of research interest was at the interface of infectious diseases and palliative care, specifically the role of antibiotics at the end of life. Additional areas of interest include antibiotic resistant organisms, the emergence and spread of resistant organisms, hospital epidemiology, and medical education. Since 2021, Dr. Juthani has been on a leave for public service to serve as Commissioner of the Connecticut Department of Public Health.

Appointments

  • Epidemiology of Microbial Diseases

    Professor
    Secondary

Other Departments & Organizations

Education & Training

Fellow
Yale University School of Medicine (2005)
Chief Resident
Memorial Sloan Kettering Cancer Center (2002)
Intern and Resident
New York-Presbyterian Hospital, Weill Cornell (2001)
Assistant Chief Resident
New York-Presbyterian Hospital, Weill Cornell (2001)
MD
Cornell University Medical College (1998)
BA
University of Pennsylvania (1994)

Research

Overview

Dr. Juthani has focused her investigative efforts on improving the diagnosis, management, and prevention of infections in older adults. Her federally funded research program has conducted studies on improving the diagnosis and management of UTI in nursing home residents. She was the Principal Investigator for a clinical trial of cranberry capsules vs placebo for the reduction of UTI in nursing home women published in JAMA. In addition, she was an investigator on a cluster randomized controlled trial to prevent pneumonia in nursing home elders. These avenues of investigation have led to her current interests in the role of antimicrobial therapy at the end of life. Her overlying research interests include hospital epidemiology, hospital acquired infections, and multi drug resistant organisms.

Additionally, this research experience has led her to a new avenue of investigation regarding the use of antibiotics with cancer patients at the end of life. Her long-term cancer goals include: 1) to have patient preferences regarding use of antibiotics addressed early on and sequentially in the trajectory of a cancer patient’s care; 2) to develop a symptom guided algorithm towards the judicious use of antimicrobial agents at the end of life; 3) to reduce hospital readmissions for infections in cancer patients where the goal of care is primarily comfort.



Medical Subject Headings (MeSH)

Aging; Infectious Disease Medicine; Nursing Homes; Palliative Care; Pneumonia; Urinary Tract Infections

Research at a Glance

Yale Co-Authors

Frequent collaborators of Manisha Juthani's published research.

Publications

2024

2023

2022

2020

Academic Achievements and Community Involvement

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    Leadership Institute, Community of Leaders

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    Reviewer

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Clinical Care

Overview

Manisha Juthani, MD, specializes in the diagnosis, management and prevention of infections in older adults. “My interest in palliative care makes me uniquely qualified to help address goals of care with older patients with underlying diseases who have recurrent infections,” she says.

Getting to know patients and the challenges they face in their home lives can go a long way, says Dr. Juthani, who recalls one patient who had end-stage renal disease, as well as a teenager at home and an ill husband. “When I took the time to understand her frustration with the recurrence of her infection and the challenging home situation, she immediately developed confidence in my care of her,” she says.

An associate professor of medicine (infectious diseases) at Yale School of Medicine, Dr. Juthani also pursues federally funded research to learn more about infections in older adults, specifically urinary tract infections and pneumonia. Her most recent area of interest is at the interface of infectious diseases and palliative care, including the role of antibiotics at the end of life.

Clinical Specialties

Internal Medicine; Infectious Diseases

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