Li Wen, MD, PhD
Professor of Medicine (Endocrinology)DownloadHi-Res Photo
Cards
Appointments
Endocrinology
Primary
Additional Titles
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Endocrinology
Primary
Additional Titles
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Endocrinology
Primary
Additional Titles
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Contact Info
About
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Titles
Professor of Medicine (Endocrinology)
Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
Appointments
Endocrinology
ProfessorPrimary
Other Departments & Organizations
- Diabetes Research Center
- Discovery to Cure Internship
- Endocrinology
- Fellowship Training
- Human and Translational Immunology Program
- Internal Medicine
Education & Training
- Postdoctoral Associate and Fellow
- Yale University (1997)
- PhD
- University of London (1992)
- MD
- Capital University of Medicine (1983)
Research
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Overview
Medical Research Interests
Antigen-Presenting Cells; Antigens, CD20; Autoimmune Diseases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; Hypersensitivity; Immune Tolerance; Immunity, Humoral; Immunity, Innate; Inflammasomes; Islets of Langerhans; Liver; Microbiota; Obesity; T-Lymphocytes, Regulatory; Toll-Like Receptors
ORCID
0000-0002-8805-2934
Research at a Glance
Yale Co-Authors
Frequent collaborators of Li Wen's published research.
Publications Timeline
A big-picture view of Li Wen's research output by year.
Research Interests
Research topics Li Wen is interested in exploring.
Juan Huang
Ningwen Tai, PhD
Jian Peng
Xin Yang
Former YSMYoujia Hu, PhD
Jianlei Gu
129Publications
5,830Citations
Diabetes Mellitus, Type 1
CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Islets of Langerhans
Autoimmune Diseases
Immune Tolerance
Publications
2026
Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia
Yang B, He L, Liu T, Ma S, Wu Y, Wen L, Emu B. Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia. Neuropsychopharmacology 2026, 1-12. PMID: 41986467, PMCID: PMC13215341, DOI: 10.1038/s41386-026-02407-0.Peer-Reviewed Original ResearchCitationsAltmetricIL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation
Pearson J, Li Y, Huang J, Peng J, Wong F, Wen L. IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation. Frontiers In Immunology 2026, 16: 1728313. PMID: 41613137, PMCID: PMC12850519, DOI: 10.3389/fimmu.2025.1728313.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Is the NOD mouse a good model for type 1 diabetes?
Wong F, Pearson J, Wen L. Is the NOD mouse a good model for type 1 diabetes? Diabetologia 2025, 69: 3-19. PMID: 41206392, PMCID: PMC12686005, DOI: 10.1007/s00125-025-06579-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricPdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice
Zhang L, Xing Y, Wang P, Gu J, Peng J, Huang J, Pearson J, Hu Y, Zhao H, Wong F, Wen L. Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice. Frontiers In Endocrinology 2025, 16: 1630979. PMID: 41234234, PMCID: PMC12605365, DOI: 10.3389/fendo.2025.1630979.Peer-Reviewed Original ResearchAltmetricToll-like receptors in B cells and obesity
Wang P, Hou C, Wong F, Wen L. Toll-like receptors in B cells and obesity. Trends In Molecular Medicine 2025, 31: 1114-1123. PMID: 40527636, DOI: 10.1016/j.molmed.2025.05.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricExtracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks
Kawiková I, Špička V, Lai J, Askenase P, Wen L, Kejík Z, Jakubek M, Valeš K, Španiel F. Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks. Frontiers In Immunology 2025, 16: 1454306. PMID: 40264776, PMCID: PMC12011847, DOI: 10.3389/fimmu.2025.1454306.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsGut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome
Geng L, Yang X, Sun J, Ran X, Zhou D, Ye M, Wen L, Wang R, Chen M. Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome. Advanced Science 2025, 12: 2412558. PMID: 40192074, PMCID: PMC12120758, DOI: 10.1002/advs.202412558.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.
Kawikova I, Hakenova K, Lebedeva M, Kleteckova L, Jakob L, Spicka V, Wen L, Spaniel F, Vales K. Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic. Physiological Research 2024, 73: s615-s639. PMID: 39589306, PMCID: PMC11627263, DOI: 10.33549/physiolres.935501.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsRegulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes
Kakabadse D, Chen D, Fishman S, Weinstein-Marom H, Davies J, Wen L, Gross G, Wong F. Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes. Frontiers In Immunology 2024, 15: 1463971. PMID: 39351219, PMCID: PMC11439686, DOI: 10.3389/fimmu.2024.1463971.Peer-Reviewed Original ResearchCitationsAltmetricBile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice
Yang X, Xu Y, Li J, Ran X, Gu Z, Song L, Zhang L, Wen L, Ji G, Wang R. Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice. MSystems 2024, 9: e00127-24. PMID: 38934542, PMCID: PMC11265269, DOI: 10.1128/msystems.00127-24.Peer-Reviewed Original ResearchCitations
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News
- September 16, 2024
Treating Obesity with Gut Microbiota
- August 14, 2024
A Link Between the Immune System and Obesity
- December 07, 2022
New Professors in Department of Internal Medicine (December 2022)
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