Jonas Christian Schupp, MD
Assistant Professor AdjunctCards
About
Research
Publications
2024
On the Ultrastructure of Aberrant Basaloid Cells in Idiopathic Pulmonary Fibrosis.
Schipke J, Panpeng S, Wrede C, Hegermann J, Ruwisch J, Werlein C, Jonigk D, Shin H, Schupp J, Mühlfeld C, Knudsen L. On the Ultrastructure of Aberrant Basaloid Cells in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2024, 71: 746-750. PMID: 39601536, DOI: 10.1165/rcmb.2024-0218le.Peer-Reviewed Original ResearchSingle-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.
Zhao A, Unterman A, Abu Hussein N, Sharma P, Nikola F, Flint J, Yan X, Adams T, Justet A, Sumida T, Zhao J, Schupp J, Raredon M, Ahangari F, Deluliis G, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling A, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 1252-1266. PMID: 38924775, DOI: 10.1164/rccm.202401-0078oc.Peer-Reviewed Original ResearchFibrotic hypersensitivity pneumonitisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsBronchoalveolar lavage cellsBlood mononuclear cellsClassical monocytesHypersensitivity pneumonitisPulmonary fibrosisT cellsImmune perturbationsLavage cellsMononuclear cellsCD8+ T cellsCytotoxic T cellsInterstitial lung diseaseHypersensitivity pneumonitis patientsCytotoxic CD4Immune aberrationsPneumonic patientsPneumonitisLung diseaseHealthy controlsImmune mechanismsPatient cellsSingle-cell transcriptomicsStudying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report
Hough R, Alvira C, Bastarache J, Erzurum S, Kuebler W, Schmidt E, Shimoda L, Abman S, Alvarez D, Belvitch P, Bhattacharya J, Birukov K, Chan S, Cornfield D, Dudek S, Garcia J, Harrington E, Hsia C, Islam M, Jonigk D, Kalinichenko V, Kolb T, Lee J, Mammoto A, Mehta D, Rounds S, Schupp J, Shaver C, Suresh K, Tambe D, Ventetuolo C, Yoder M, Stevens T, Damarla M. Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2024, 71: 388-406. PMID: 39189891, PMCID: PMC11450313, DOI: 10.1165/rcmb.2024-0330st.Peer-Reviewed Original ResearchVascular diseaseEndothelial cell injuryAmerican Thoracic SocietyEndothelial cell functionPulmonary endotheliumMechanical propertiesLung endotheliumChronic vascular diseaseEndothelial functionPathophysiological mechanismsHealth and DiseaseVascular locationThoracic SocietyCell injuryEndotheliumCell functionTissue compartmentsDiseaseVascular circuitBidirectional signalingTranslation of discoveriesBloodDissecting the immune cell niche in pulmonary sarcoidosis – CXCL10+ monocyte-derived macrophages are potential drivers of TH17.1 inflammation
Ruwisch J, Schupp J, Bartkute B, Artysh N, Kaminski N, Prasse A. Dissecting the immune cell niche in pulmonary sarcoidosis – CXCL10+ monocyte-derived macrophages are potential drivers of TH17.1 inflammation. 2024, oa953. DOI: 10.1183/13993003.congress-2024.oa953.Peer-Reviewed Original ResearchSingle-nuclei RNA-seq reveals aberrant cell populations in restrictive allograft syndrome after lung transplantation
Leiber L, Christian L, Neubert L, Yilmaz H, Kamp J, Plucinski E, Welte T, Falk C, Kaminski N, Jonigk* D, Gottlieb* J, Schupp* J. Single-nuclei RNA-seq reveals aberrant cell populations in restrictive allograft syndrome after lung transplantation. 2024, oa985. DOI: 10.1183/13993003.congress-2024.oa985.Peer-Reviewed Original ResearchNovel insight into alveolar capillary dysplasia from multi-omics and 3D imaging
Park D, Kamp J, Neubert L, Freitag H, Schupp J, Braubach P, Christoph W, Florian L, Salditt T, Reichmann J, Welte T, Ruhparwar A, Ius F, Schwerk N, Bergmann A, Von Hardenberg S, Griese M, Rapp C, Olsson K, Fuge J, Hoeper M, Jonigk D, Knudsen L, Kuehnel M. Novel insight into alveolar capillary dysplasia from multi-omics and 3D imaging. 2024, oa1900. DOI: 10.1183/13993003.congress-2024.oa1900.Peer-Reviewed Original Research129Xe magnetic resonance imaging for monitoring lung function and microstructure in patients on treatment for progressive fibrosing interstitial lung disease
Kern A, Voskrebenzev A, Klimeš F, Pink I, Schupp J, Seeliger B, Konietzke M, Peter D, Risse F, Welte T, Wacker F, Hohlfeld J, Shin H, Prasse A, Vogel-Claussen J. 129Xe magnetic resonance imaging for monitoring lung function and microstructure in patients on treatment for progressive fibrosing interstitial lung disease. 2024, oa5465. DOI: 10.1183/13993003.congress-2024.oa5465.Peer-Reviewed Original ResearchSingle-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.
Unterman A, Zhao A, Neumark N, Schupp J, Ahangari F, Cosme C, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida T, Gomez J, Herazo-Maya J, Dela Cruz C, Herzog E, Kaminski N. Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 484-496. PMID: 38717443, PMCID: PMC11351796, DOI: 10.1164/rccm.202306-0979oc.Peer-Reviewed Original ResearchStable idiopathic pulmonary fibrosisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsProgressive idiopathic pulmonary fibrosisPeripheral immune systemT cellsPulmonary fibrosisCohort of IPF patientsAssociated with decreased survivalIdiopathic pulmonary fibrosis patientsPeripheral blood mononuclear cell samplesPeripheral blood cell populationsImmune systemFraction of TregsRegulatory T cellsBlood mononuclear cellsBlood cell populationsFlow cytometry analysisImmune aberrationsIPF patientsTregsMononuclear cellsSingle-cell RNA sequencingLung homogenatesMonocyte chemoattractantCellular Mechanisms Underlying the Pathogenetic Role of the Primary Cilium in Pulmonary Arterial Hypertension
Melnikov A, Solymosi P, Pennitz P, Schupp J, Nouailles G, Perret P, Gallo K, Hegemann N, Nambiar Veetil N, Klepetko W, Sinn K, Erfinanda L, Simmons S, Kucherenko M, Knosalla C, Preissner R, Kwapiszewska G, Witzenrath M, Kuebler W. Cellular Mechanisms Underlying the Pathogenetic Role of the Primary Cilium in Pulmonary Arterial Hypertension. 2024, a6790-a6790. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6790.Peer-Reviewed Original ResearchsnRNAseq of IPF Stromal Cells Reveals Dysfunctional Gene Co-expression Profile
Sharma P, Taylor S A, Anderson S, Nekola F, Giuseppe D, Yan X, Schupp J, Balayev A, Justet A, Wuyts W, Vanaudenaerde B, Kaminski N. snRNAseq of IPF Stromal Cells Reveals Dysfunctional Gene Co-expression Profile. 2024, a4903-a4903. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4903.Peer-Reviewed Original Research