John Elefteriades, MD
William W.L. Glenn Professor of Surgery (Cardiac)Cards
Contact Info
Cardiac Surgery
P.O. Box 208039
New Haven, CT 06520-8039
United States
About
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Titles
William W.L. Glenn Professor of Surgery (Cardiac)
Biography
Dr. John Elefteriades is the William W.L. Glenn Professor of Cardiothoracic Surgery and former Chief of Cardiothoracic Surgery at Yale University and Yale New-Haven Hospital. He has been among the most clinically active academic surgeons in the country.
Dr. Elefteriades graduated magna cum laude with a triple concentration in Physics, French and Psychology from Yale University. He received his MD degree from the Yale University School of Medicine. He trained at Yale in both general surgery and cardiothoracic surgery. After completing his training, he joined the faculty at the Yale University School of Medicine.
He has performed all aspects of adult cardiac and thoracic surgery. He is a recognized authority in interventions for the failing left ventricle, including coronary artery bypass grafting, left ventricular aneurysmectomy, and artificial heart implantation. Dr. Elefteriades directs the Aortic Institute at Yale, one of the nation's largest facilities for treatment of the dilated thoracic aorta. He conducts laboratory research in new techniques of heart transplantation. Among his research projects, he is working to identify the genetic mutations responsible for thoracic aortic aneurysms.
Dr. Elefteriades serves on multiple scientific advisory and editorial boards. He is a past President of the Connecticut Chapter of the American College of Cardiology and member of the national Board of Governors of the College. Dr. Elefteriades is also past President of the International College of Angiology. He serves on the editorial board of the American Journal of Cardiology, the Journal of Cardiac Surgery, Cardiology, and the Journal of Thoracic and Cardiovascular Surgery as well as being Editor-in-Chief of the journal AORTA. He has been a member of the Thoracic Surgery Director's Association and has been named consistently in The Best Doctors in America. He is a frequently requested international lecturer, visiting professor and guest surgeon. He is the author of over 400 scientific publications on a wide range of cardiac and thoracic topics. He was selected as one of the ten best doctors in America by Men’s Health magazine. He has been featured in many dozens of print, radio, and television presentations. He has received the Walter Bleifeld Memorial Award for Distinguished Contribution in Clinical Research in Cardiology and the John B. Chang Research Achievement Award. In 2005 he was selected to lecture at the Leadership in Biomedicine Series at the Yale University School of Medicine. In 2006, he received the Socrates Award from the Thoracic Residents Association, Thoracic Surgery Directors' Association, and the Society of Thoracic Surgeons, recognizing exceptional achievement in teaching and mentorship of residents.
Dr. Elefteriades was named the William W.L. Glenn Professor of Cardiothoracic Surgery in 2006. This endowed chair honors the memory of Dr. Elefteriades’ mentor, Dr. Glenn. Dr. Elefteriades is the author of the books House Officer Guide to ICU Care (1st, 2nd, and 3rd Editions), Advanced Treatment Options for the Failling Left Ventricle, Your Heart: The Owner's Guide, Acute Aortic Disease, Extraordinary Hearts: A Journey of Cardiac Medicine and the Human Spirit, The Woman's Heart: An Owner's Guide, and the medical ethics thriller Transplant.
In 2017, Dr. Elefteriades was awarded an Honorary Phd degree from the University of Liege (Belgium) in recognition of his work in diagnosis and treatment of aortic diseases.
In 2020, Dr. Elefteriades was recognized by expertscape as the top aortic specialist in the world.
Appointments
Cardiac Surgery
ProfessorPrimary
Other Departments & Organizations
- Cardiac Surgery
- Surgery
- Yale Center for Thoracic Aortic Disease
- Yale Medicine
- Yale Ventures
Education & Training
- Chief Resident
- Yale-New Haven Hospital (1983)
- Resident
- Yale-New Haven Hospital (1982)
- Chief Resident
- Yale-New Haven Hospital (1981)
- Resident
- Yale-New Haven Hospital (1980)
- MD
- Yale University (1976)
- BA
- Yale University, Psychology (1972)
- Fellow
- Yale-New Haven Hospital, New Haven, CT
Board Certifications
Thoracic & Cardiac Surgery
- Certification Organization
- AB of Thoracic Surgery
- Latest Certification Date
- 2014
- Original Certification Date
- 1985
Research
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Overview
Dr. Elefteriades and his team at the Aortic Institute have contributed to our understanding of when (at what size) aneurysms are likely to rupture and when surgery is necessary. They have elucidated the family patterns of aneurysm disease, as well as determined the exact changes in "letters" of the genetic alphabet that allow aneurysms to develop. They have developed and advanced the techniques for safe, effective surgery on the thoracic aorta.
Medical Research Interests
ORCID
0000-0001-6255-8139- View Lab Website
Aortic Institute at Yale
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Mohammad Abdullah Zafar, MBBS
George Tellides, MD, PhD
Hamid Mojibian, MD
Sandip Mukherjee, MD, FACC
Wanda Popescu, MD
Lynda Rosenfeld, MD
Aortic Aneurysm, Thoracic
Coronary Artery Bypass
Heart Aneurysm
Publications
2025
Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology
Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz R, Elefteriades J, Grewal N. Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology. Cardiovascular Pathology 2025, 80: 107789. PMID: 41177471, DOI: 10.1016/j.carpath.2025.107789.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTAV patientsBAV patientsElastic lamellaeAortic wallValve morphologyAortic valve morphologyAscending thoracic aortaAortic wall samplesFiber pathologyClinical outcomesThoracic aortaAbdominal aortaPathological featuresAortaAdult aortaPatientsTricuspidAge groupsAortopathyIntimal layerAdult humansBAVLiterature reviewAgeLamellar countThromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era
Strachan S, Zafar M, Ziganshin B, Elefteriades J. Thromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era. Annals Of Thoracic Surgery Short Reports 2025 DOI: 10.1016/j.atssr.2025.07.015.Peer-Reviewed Original ResearchAltmetricEfficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. Vascular Pharmacology 2025, 159: 107494. PMID: 40204023, DOI: 10.1016/j.vph.2025.107494.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsThoracic aortic aneurysmRandomized Controlled TrialsPooled risk ratioB-blockersAortic dissectionClinical outcomesAortic aneurysmRisk ratioRisk of aortic dissectionMeta-analysis of randomized controlled trialsControlled TrialsB-blocker treatmentCompared to placeboBeta-blocking agentsCochrane Risk of Bias 2 toolRisk of Bias 2 toolRobust randomized controlled trialsInverse variance-weighted random-effects modelRisk of bias assessmentRandom-effects modelEvidence of benefitSystematic literature searchAortic eventsEvidence-based recommendationsFollow-upPotential Protective Role of Diabetes Mellitus on Aortic Aneurysms
Epstein E, Elefteriades J. Potential Protective Role of Diabetes Mellitus on Aortic Aneurysms. Aorta 2025, 13: 039-045. PMID: 40759177, PMCID: PMC12472811, DOI: 10.1055/a-2624-0594.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAbdominal aortic aneurysmGrowth of abdominal aortic aneurysmsAortic aneurysmDiabetes mellitusRisk of mortalityPotential protective roleAbdominal aortic aneurysm repairHigh riskAbdominal aortic aneurysm ruptureD-dimer levelsHigher risk of mortalityStatistically significant differenceDiabetic aortaDiabetes protectionAneurysm diameterD-dimerLower homocysteineAneurysmLow riskPatientsMellitusSignificant differenceProtective effectMortality
2024
Protective biomechanical and histological changes in the false lumen wall in chronic type B aortic dissection
Dong H, Liu M, Cebull H, Chhabra A, Zhou Y, Piccinelli M, Oshinski J, Elefteriades J, Gleason R, Leshnower B. Protective biomechanical and histological changes in the false lumen wall in chronic type B aortic dissection. JTCVS Open 2024, 23: 60-68. PMID: 40061520, PMCID: PMC11883685, DOI: 10.1016/j.xjon.2024.11.012.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChronic phaseChronic type B aortic dissectionType B aortic dissectionHistological changesB aortic dissectionIncreased Aortic StiffnessAcute to chronic phaseAortic stiffnessDecreased elastinIncreased collagenQuantification of collagenBiaxial tension testsStress-strain curvesBiomechanical stiffnessTension testsAssess stiffnessHuman tissuesCollagenGenetics of aortic aneurysm disease: 10 key points for the practitioner
Elefteriades J, Zafar M, Ziganshin B. Genetics of aortic aneurysm disease: 10 key points for the practitioner. JTCVS Open 2024, 21: 58-63. PMID: 39534337, PMCID: PMC11551243, DOI: 10.1016/j.xjon.2024.07.014.Peer-Reviewed Original ResearchCitationsEditorial: Novel biomarkers in acute aortic dissection
Georgiadou P, Sbarouni E, Elefteriades J. Editorial: Novel biomarkers in acute aortic dissection. Frontiers In Cardiovascular Medicine 2024, 11: 1457521. PMID: 39087070, PMCID: PMC11288941, DOI: 10.3389/fcvm.2024.1457521.Peer-Reviewed Original ResearchThe use of 4-dimensional flow magnetic resonance imaging and fluid structure interaction analysis to predict failure of medical therapy in acute uncomplicated type B aortic dissection
Cebull H, Liu M, Piccinelli M, Dong H, Naeem M, Du Y, Oshinski J, Gleason R, Elefteriades J, Leshnower B. The use of 4-dimensional flow magnetic resonance imaging and fluid structure interaction analysis to predict failure of medical therapy in acute uncomplicated type B aortic dissection. JTCVS Techniques 2024, 27: 40-44. PMID: 39478892, PMCID: PMC11519730, DOI: 10.1016/j.xjtc.2024.06.019.Peer-Reviewed Original ResearchCitationsAltmetricPilot study exploring artificial intelligence for facial-image-based diagnosis of Marfan syndrome
Saksenberg D, Mukherjee S, Zafar M, Ziganshin B, Elefteriades J. Pilot study exploring artificial intelligence for facial-image-based diagnosis of Marfan syndrome. Heliyon 2024, 10: e33858. PMID: 39055814, PMCID: PMC11269824, DOI: 10.1016/j.heliyon.2024.e33858.Peer-Reviewed Original ResearchCitationsAltmetricConceptsConvolutional neural networkFacial imagesArtificial intelligenceF1 scoreNeural networkUtilization of convolutional neural networksAccuracy of neural networksPotential of artificial intelligenceTest setMarfan syndromeFacial featuresIntelligenceOverall accuracyNetworkAccuracyDiagnosis of Marfan syndromeImagesROC curveDegree of accuracyArea under the ROC curveMarfan's diseaseClinical recognitionPilot studyThoracic aortaMarfan4D Flow MRI-Derived Hemodynamic Parameters Related to Growth in Acute Type B Aortic Dissections
Cebull H, Liu M, Dong H, Elefteriades J, Gleason R, Piccinelli M, Oshinski J, Leshnower B. 4D Flow MRI-Derived Hemodynamic Parameters Related to Growth in Acute Type B Aortic Dissections. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/4770.Peer-Reviewed Original ResearchConceptsType B aortic dissectionAcute type B aortic dissectionB aortic dissectionAortic growthHigh-risk patientsPreemptive treatmentSurgical outcomesTBAD patientsIn vivo hemodynamicsStratify riskHemodynamic parametersImprove outcomesHemodynamic markersAcute patientsPatientsDissectionFlow MRIHemodynamic metricsTearsMRI dataOutcomes
Academic Achievements & Community Involvement
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Activities
activity Neither extreme LV dilation nor lack of ischemia on stress testing should contradict CABG for advanced ischemic cardiomyopathy
01/01/2000 - PresentLectureInvited Lecture, “Neither extreme LV dilation nor lack of ischemia on stress testing should contradict CABG for advanced ischemic cardiomyopathy,” 3rd International Congress on Coronary Artery Disease- From Prevention to InterventionDetailsLyon, Auvergne-Rhône-Alpes, FranceAbstract/SynopsisInvited Lecture, “Neither extreme LV dilation nor lack of ischemia on stress testing should contradict CABG for advanced ischemic cardiomyopathy,” 3rd International Congress on Coronary Artery Disease- From Prevention to Intervention
activity Scientific Executive Committee
01/01/1999 - PresentResearchDetailsWashington, Georgia, United StatesAbstract/Synopsis1st International Congress on Heart Disease, International Academy of Cardiology
Honors
honor "top expert in Aortic Aneurysm in the world"
10/15/2020National AwardexpertscapeDetailsUnited Stateshonor Connecticut Magazine Top Docs 2015
04/01/2016Regional AwardConnecticut MagazineDetailsUnited Stateshonor Connecticut Magazine Top Docs 2016
04/03/2015Regional AwardConnecticut MagazineDetailsUnited Stateshonor Socrates Award
01/22/2006National AwardThoracic Residents Association, Thoracic Surgery Directors' Association, and Society of Thoracic Surgeons (Chicago, IL), recognizing exceptional achievement in teaching and mentorship of residents.DetailsUnited Stateshonor Most Outstanding Invited Faculty Presentation- "The Aneurysmatic Patient: From Large to Multifocal."
10/01/2005International Award6th International Advances in Understanding Aortic Diseases MeetingDetailsUnited States
News & Links
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Media
- This image from our Scientific American article conveys vividly the threat represented by aneurysms of the ascending aorta, which are silent until they tear or rupture. If you have a family history of such aneurysms, you should be investigated.
- If you can cross your thumb all the way over the edge of your flat palm, it is possible that you have aneurysm disease. This Thumb-Palm Sign is evidence that the long bones are excessive and the joints are lax.. This should be called to the attention of your doctor. An ECHO or CT scan of your thoracic aorta will probably be needed.
News
- February 28, 2025Source: Yale Ventures
YSM Faculty Win Awards From the Blavatnik Fund for Innovation at Yale
- August 12, 2024
AI Accurately Diagnoses a Genetic Condition From Facial Photographs
- January 02, 2024Source: Medscape
Ascending Thoracic Aortic Aneurysms: A 'Silver Lining'?
- August 17, 2022
AHA Scientific Sessions 2022: Latest updates from Yale Cardiovascular Medicine
Get In Touch
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Contacts
Cardiac Surgery
P.O. Box 208039
New Haven, CT 06520-8039
United States