Joao P. De Aquino, MD

Featured Publications

• Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies

  De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

  Altmetric

  MeSH Keywords

• Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans

  Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D’Souza D. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.

  Peer-Reviewed Original Research

  Citations

  Altmetric

  MeSH Keywords

• Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic

  De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.

  Peer-Reviewed Original Research

  Citations

  Altmetric

  MeSH Keywords

• From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder

  Weleff J, Nunes J, Costa G, Sofuoglu M, MacLean R, De Aquino J. From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3036-3053. PMID: 38627909, PMCID: PMC11480258, DOI: 10.1111/bcp.16045.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

  Altmetric

• Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations

  Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024, 90: 2985-3002. PMID: 38556851, DOI: 10.1111/bcp.16055.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

  Altmetric

• The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies

  Costa G, Nunes J, Heringer D, Anand A, De Aquino J. The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies. The American Journal Of Drug And Alcohol Abuse 2024, 50: 12-26. PMID: 38225727, DOI: 10.1080/00952990.2023.2287406.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

  Altmetric

  MeSH Keywords

• Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility

  De Aquino J. Fatty Acid Amide Hydrolase, Neurodevelopment, and Alcohol: Illuminating the Intricacies of the Endocannabinoid System in Addiction Susceptibility. Biological Psychiatry 2023, 94: e19-e21. PMID: 37558315, DOI: 10.1016/j.biopsych.2023.06.027.

  Peer-Reviewed Original Research

  Citations

  MeSH Keywords

• Quantitative sensory testing of pain in persons with opioid use disorder on opioid agonist treatment: a scoping review

  Oliveira D, Costa G, Fontenele R, Córdoba-Delgado M, Funaro M, Campbell C, Fiellin D, Angarita G, De Aquino J. Quantitative sensory testing of pain in persons with opioid use disorder on opioid agonist treatment: a scoping review. Pain Medicine 2025, 27: 243-253. PMID: 40990827, PMCID: PMC13017201, DOI: 10.1093/pm/pnaf132.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

• Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study

  De Aquino J, Costa G, Nunes J, Hudak J, Odette M, Garland E. Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study. Drug And Alcohol Dependence 2025, 275: 112812. PMID: 40779835, PMCID: PMC12396927, DOI: 10.1016/j.drugalcdep.2025.112812.

  Peer-Reviewed Original Research

  Altmetric

  MeSH Keywords

• The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder

  Costa G, Ra J, Meyerovich J, Pittman B, Nunes J, De Aquino J. The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder. Journal Of Addiction Medicine 2025, 20: 351-358. PMID: 40728216, PMCID: PMC13166079, DOI: 10.1097/adm.0000000000001553.

  Peer-Reviewed Original Research

  Altmetric