Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJames Clune, MD
Associate Professor AdjunctAbout
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Titles
Associate Professor Adjunct
Leader, Multidisciplinary Care, Melanoma Program
Biography
Dr. James Clune is an Associate Professor of Surgery and Plastic and Reconstructive Surgery at the Yale School of Medicine and member of the Yale Cancer Center. Dr. Clune specializes in the reconstruction and treatment of patients with complex malignancies. He works closely with the surgical oncologists, orthopedic oncologists, neurosurgeons, gynecologic oncologists and dermatologists to provide comprehensive cancer care within the cancer center. He is a member of multiple cancer tumor boards and is a multidisciplinary team leader. In addition, he also specializes in procedures for the treatment of tumors of the upper extremity, brachial plexus tumors, brachial plexus reconstruction and peripheral nerves. Research interests include reconstructive targeted muscle reinnervation after amputation for sarcoma, oncoplastic reconstruction techniques and understanding quality outcomes for patients after cancer reconstruction.
Dr. Clune graduated from Wesleyan University and attained his medical degree from the George Washington University School of Medicine. He then completed a post-doctoral research fellowship at Children's Hospital Boston in craniofacial reconstruction. His specialty training in Plastic and Reconstructive surgery was completed at Yale with a special research focus in cancer reconstruction. He then completed a fellowship in upper extremity surgery at the University of California and Shriners Hospital for Children Los Angeles with Dr. Neil Ford Jones, where he focused on microsurgical reconstruction of the upper extremity, soft tissue tumors of the extremities, and peripheral nerve and brachial plexus reconstruction.
After completion of his fellowship in California, additional training was completed in adult and pediatric brachial plexus reconstruction at the Hospital Universitario La Paz in Madrid, Spain with Dr. Aleksandar Lovic and reconstructive microsurgery in Santander, Spain with Dr. Francisco Pinal.
Dr. Clune has been named one of the "Top Doctors" for Reconstructive Oncology in Connecticut Magazine for the past 3 years.
Appointments
Plastic & Reconstructive Surgery
Associate Professor AdjunctPrimary
Other Departments & Organizations
- Hand and Microsurgery Program
- Plastic & Reconstructive Surgery
- Surgery
Education & Training
- Fellowship Upper Extremity Reconstruction
- Shriners Hospital for Children/University of California (2016)
- Resident Plastic Surgery
- Yale New Haven Hospital, Yale School of Medicine (2015)
- Post-Doctoral Fellow
- Children's Hospital Boston, Harvard Medical School (2009)
- MD
- George Washington School of Medicine (2008)
- BA
- Wesleyan University (1999)
Research
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Overview
Tumor immunology; Tumor genetics
Medical Research Interests
ORCID
0000-0002-2398-4634
Research at a Glance
Yale Co-Authors
Publications Timeline
Harriet Kluger, MD
Kelly Olino, MD, FACS
Thuy Tran, MD, PhD
Jeffrey Ishizuka, MD, DPhil
Mario Sznol, MD
Sajid A Khan, MD, FACS, FSSO
Publications
2025
Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma
Frey A, Clulo K, Fei Y, Dumit T, Scallo F, Williams J, Chang E, Perry C, Wirth L, Jacobs D, Braun D, Bosenberg M, Tran T, Clune J, Kluger H, Olino K, Ishizuka J. Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma. Cell Reports 2025, 44: 116359. PMID: 41042672, DOI: 10.1016/j.celrep.2025.116359.Peer-Reviewed Original ResearchAltmetricConceptsMerkel cell carcinomaMRNA vaccinesCell carcinomaCD8+ T cell memoryAntigen-specific T cell expansionTumor cell expressionT cell expansionT cell memoryTumor cell survivalTumor controlMemory differentiationAntigen lossResponse durabilityMurine studiesAntigen exposureIL-7Mouse modelOptimal vaccine targetsCell expressionMRNA technologyPatient samplesMRNA therapeuticsStrong antigensTumorViral oncoproteinsReal-world outcomes with T-VEC in patients with anti-PD-1 resistant in-transit disease from melanoma and Merkel cell carcinoma
Su D, McNamara M, Kaszycki M, Frey A, Ishizuka J, Costa P, Tran T, Kluger H, Clune J, Weiss S, Olino K. Real-world outcomes with T-VEC in patients with anti-PD-1 resistant in-transit disease from melanoma and Merkel cell carcinoma. Surgical Oncology Insight 2025, 2: 100120. DOI: 10.1016/j.soi.2024.100120.Peer-Reviewed Original ResearchCitationsConceptsMerkel cell carcinomaMerkel cell carcinoma casesT-VECCell carcinomaMedian numberAnti-PD-1 blockadeStage IIIB-IV melanomaAdvanced Merkel cell carcinomaIn-Transit MelanomaIn-transit diseaseICI therapyTalimogene laherparepvecAdvanced melanomaCancer immunotherapyMetastatic sitesPartial responseIn-transitRegional metastasesMedian ageGrade 3Adverse eventsTreatment cyclesDisease progressionMelanomaPatientsThe Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students
Kersh L, Serrato P, Anderson C, Raguveer V, Peck C, Ally S, Gondi I, Subhedar S, Rollins A, Hauser B, Jayaram A, Hill S, Wariso B, Rehman S, Alliance G, Clune J. The Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students. Journal Of Surgical Education 2025, 82: 103441. PMID: 39894006, DOI: 10.1016/j.jsurg.2025.103441.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMedical school experienceGlobal surgeryMedical studentsMedical schoolsSurgical mission tripsCross-sectional survey studyAssociated with lower oddsMission tripsAssociated with increased oddsMedical school curriculumGlobal health researchU.S. medical studentsCareer planningSurgery researchGlobal surgery educationResponding medical studentsMultivariate regression modelHealth researchSurgery opportunitiesLower oddsSchool experiencesSurgeryOddsSurgery educationMedical institutionsAnatomic variation of the spinal accessory innervation pattern of the sternocleidomastoid muscle: A cadaveric study
Noel O, Allam O, Vafa A, Gonzalez L, Lapre P, Jackie Oh S, Hodelin C, Clune J. Anatomic variation of the spinal accessory innervation pattern of the sternocleidomastoid muscle: A cadaveric study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 102: 142-144. PMID: 39921925, DOI: 10.1016/j.bjps.2025.01.042.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSpinal accessory nerveSAN courseNeck dissectionAnatomical coursePosterior triangle of the neckCadaveric studySternocleidomastoid (SCMPosterior triangleSternocleidomastoid muscleIndian patientsAccessory nerveClinical studiesIatrogenic injurySternocleidomastoidAnatomical variationsNeckInnervation patternDissectionNerveAnatomy
2024
The Perceived Impact of Global Surgery Engagement on Career Advancement among US Medical Students
Serrato P, Solaiman R, Vohra H, Hu K, Jain A, Alamdeen Y, Fagla B, Peck C, Hill S, Wariso B, Rehman S, Subhedar S, Kersh L, Anderson C, Clune J, Alliance G. The Perceived Impact of Global Surgery Engagement on Career Advancement among US Medical Students. Journal Of Surgical Education 2024, 82: 103404. PMID: 39740592, DOI: 10.1016/j.jsurg.2024.103404.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAssociated with increased oddsGlobal surgeryResidency applicantsMultivariate logistic regression modelGlobal surgery programsAcademic global surgeryLogistic regression modelsUS medical studentsMultivariate analysisSurgeryMedical studentsSurgery interest groupSurgery programsSurgery trainingPerceived impactCross-sectional survey studyMedical school curriculumSurgeonsMedical institutionsMedical students' perceptionsSurgery participantsHealth equityOddsCareer advancementMedical schoolsComplications following open treatment of frontal sinus fracture: A nationwide analysis of 1492 patients
Kammien A, Noel O, Aregbe A, Clune J. Complications following open treatment of frontal sinus fracture: A nationwide analysis of 1492 patients. Journal Of Cranio-Maxillofacial Surgery 2024, 53: 129-133. PMID: 39592374, DOI: 10.1016/j.jcms.2024.11.012.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsTreatment of frontal sinus fracturesFrontal sinus fracturesCerebrospinal fluid leakSinus fracturesFrontal sinus obliterationSurgical site infectionOpen treatmentSinus obliterationBrain abscessComplication rateSite infectionFluid leakConcomitant fracturesDays of follow-upSingle-institution studyDay of surgeryType of fractureAssociated with increased likelihoodPosterior tableAdult patientsConcomitant injuriesIncreased injury severityNationwide cohortFollow-upMultivariate analysisRisk factors and outcomes after surgery for malignant neoplasm of the parotid gland: An ACS-NSQIP study
Knoedler L, Knoedler S, Hoch C, Safi A, Wollenberg B, Alfertshofer M, Pomahac B, Kauke-Navarro M, Clune J. Risk factors and outcomes after surgery for malignant neoplasm of the parotid gland: An ACS-NSQIP study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 101: 264-274. PMID: 39448324, DOI: 10.1016/j.bjps.2024.09.067.Peer-Reviewed Original ResearchCitationsConceptsBlood urea nitrogenRisk factorsRenal failureParotid glandMalignant neoplasmsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseAssociated with higher creatinineNational Surgical Quality Improvement Program databaseMicrosurgical proceduresPre-operative risk factorsQuality Improvement Program databaseRisk of postoperative adverse eventsBlood urea nitrogen levelsHigher ASA classPostoperative adverse eventsOccurrence of complicationsPost-surgical outcomesTumor resectionComplication rateFlap surgeryPostoperative outcomesACS-NSQIPASA classHigher creatinineCauses of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era
Lee D, McNamara M, Yang A, Yaskolko M, Kluger H, Tran T, Olino K, Clune J, Sznol M, Ishizuka J. Causes of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era. Pigment Cell & Melanoma Research 2024, 37: 847-853. PMID: 39073002, PMCID: PMC11809125, DOI: 10.1111/pcmr.13188.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSite of metastasisPattern of metastatic diseaseMelanoma mortalityRetrospective observational cohort studyCause of cancer mortalityDistant lymph nodesObservational cohort studyDiagnosis to deathImmunotherapy eraAdvanced melanomaMetastatic diagnosisMetastatic diseaseMetastatic melanomaImmunotherapy treatmentRespiratory failureCause of deathMedian timeLymph nodesTherapeutic advancesCohort studyMelanomaImmunotherapyMechanism of deathPatientsEnd of lifeCharacteristics and Experiences Associated with Interest in Global Surgery: What Brings US Medical Students to the Field?
Brady N, Peck C, Anderson C, Shamim A, Kersh L, Gondi I, Rollins A, Subhedar S, Jayaram A, Hauser B, Hill S, Wariso B, Rehman S, Clune J, Alliance G. Characteristics and Experiences Associated with Interest in Global Surgery: What Brings US Medical Students to the Field? Journal Of Surgical Education 2024, 81: 1258-1266. PMID: 39013668, DOI: 10.1016/j.jsurg.2024.06.013.Peer-Reviewed Original ResearchAltmetricConceptsGlobal health experiencesAssociated with interestGlobal surgeryMedical studentsHealth experiencesCross-sectional survey studyExperiences of medical studentsUS medical studentsUS medical schoolsMiddle-income countriesMedical student interestInternational service experiencesUnited StatesMultivariate analysisSurgeryHispanic/Latino ethnicityBillion people lack accessDescriptive statisticsClinical experienceMedical educationSurgical careMedical schoolsMultivariate regressionDemographic factorsOnline surveyCauses of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era.
Lee D, Yang A, McNamara M, Kluger H, Tran T, Olino K, Clune J, Sznol M, Ishizuka J. Causes of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era. Journal Of Clinical Oncology 2024, 42: e21522-e21522. DOI: 10.1200/jco.2024.42.16_suppl.e21522.Peer-Reviewed Original ResearchAltmetricConceptsImmune checkpoint inhibitorsYale Cancer CenterAdvanced melanomaMetastatic diseaseMetastatic melanomaRespiratory failureSite of metastatic diseasePattern of metastatic diseaseDied of respiratory failureAnti-CTLA4 treatmentRetrospective observational cohort studyAnti-PD1 therapyDistant lymph nodesPatients aged >Site of diseaseSurvival of patientsObservational cohort studyMulti-system involvementDiagnosis to deathImmunotherapy eraAnti-PD1Checkpoint inhibitorsInstitutional review boardMetastatic sitesMetastatic diagnosis
Academic Achievements & Community Involvement
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Activities
activity National Plastic Surgery Advisory Board
09/12/2022 - PresentAdvisory BoardsMemberDetailsVA
Honors
honor Yale Cancer Center Clinician of the Year
04/03/2024Yale School of Medicine AwardSmilow Cancer HospitalDetailsUnited States
News
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News
- October 28, 2025
Yale Develops Dual-Action Vaccine to Combat Aggressive Merkel Cell Carcinoma
- May 14, 2025Source: NBC Connecticut (with Dr. James Clune)
May is Skin Cancer Awareness Month
- December 31, 2024
YCC Publications 2024
- November 28, 2024
Unexpected Findings in Study of T Cells, Considered Front-line Fighters Against Advanced Melanoma
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