Huey Cai
Research Scientist of Ophthalmology and Visual ScienceCards
About
Research
Publications
2025
Association of physical activity with gut microbiome among low-income black American adults in the Southern Community Cohort Study
Shi J, Nguyen S, Yu D, Wang L, Liu L, Cai H, Wu J, Long J, Cai Q, Shrubsole M, Zheng W, Shu X. Association of physical activity with gut microbiome among low-income black American adults in the Southern Community Cohort Study. Gut Microbes Reports 2025, 2: 2589861. DOI: 10.1080/29933935.2025.2589861.Peer-Reviewed Original ResearchModerate-vigorous PASouthern Community Cohort StudyPhysical activityCommunity Cohort StudyGut microbiomeAmerican adultsBlack American adultsA-diversityAbundance of individual speciesMetabolic pathwaysAssociation of physical activityShotgun metagenomic sequencingCohort studyBray-Curtis dissimilarityMicrobial metabolic pathwaysGeneralized linear regression modelsMetagenomic sequencingXyloglucan degradationBacterial speciesMicrobial compositionPA dataIndividual speciesBacteroides speciesCohort enrollmentLinear regression modelsHigher lung cancer risk among female never-smokers than males in a large married couple study
Cai H, Shu X, Wu S, Gao Y, Lan Q, Rothman N, Zheng W, Yang G. Higher lung cancer risk among female never-smokers than males in a large married couple study. Lung Cancer 2025, 210: 108836. PMID: 41237664, DOI: 10.1016/j.lungcan.2025.108836.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosAge-standardized incidence rateLung cancer riskHazard ratioCancer riskIncidence rateHigher lung cancer riskAge-standardized ratesIncident lung cancerIntensity of cigarette smokingFemale never-smokersDual-smoker couplesEver smokingNever smokersRate ratiosCox regression modelsNever-smokersCohort studyMultivariable adjustmentCigarette smokingLung cancerSex differencesRegression modelsCohortSmokingAssessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study.
DeMoulin D, Cai H, Cai Q, Zheng W, Shu X. Assessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study. Cancer Epidemiology Biomarkers & Prevention 2025, 34: 2104-2116. PMID: 40900641, PMCID: PMC12477761, DOI: 10.1158/1055-9965.epi-25-0342.Peer-Reviewed Original ResearchAssociated with colorectal cancerAssociated with lung cancerCancer riskColorectal cancerShanghai Men's Health StudyChinese menAssociated with cancer riskCancer risk factorsConfidence intervalsC-reactive proteinMen's Health StudyProspective cohort studyHigh-risk individualsPlasminogen activator inhibitor type 1Monocyte chemoattractant protein-1Health StudyTargeted interventionsLung cancerCox regression modelsCohort studyHazard ratioInterleukin-8Obesity biomarkersRisk factorsInflammation biomarkersAssociations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans
Xu S, Cai H, Wu J, Shi J, Courtney R, Yoon H, Shu X, Blot W, Zheng W, Cai Q. Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans. Carcinogenesis 2025, 46: bgaf052. PMID: 40879454, PMCID: PMC12504949, DOI: 10.1093/carcin/bgaf052.Peer-Reviewed Original ResearchLC riskOdds ratioSouthern Community Cohort StudyIncident LC casesAfrican AmericansConfidence intervalsCommunity Cohort StudyLung cancer riskSerum ALT levelsPotential effect modifiersConditional logistic regressionLiver enzyme levelsEuropean AmericansMatched ControlsALT levelsCancer riskInverse associationLow-incomeEffect modifiersStudy participantsBaseline serum alanine aminotransferaseBaseline serum alkaline phosphataseLowest tertileMedian follow-up timeCohort studySex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging
Fu J, Xu W, Yu D, Jiang Y, Wang L, Cai H, Xia Q, Shu X, Zheng W. Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging. Aging Cell 2025, 24: e70192. PMID: 40757475, PMCID: PMC12507401, DOI: 10.1111/acel.70192.Peer-Reviewed Original ResearchPatterns of gut microbiotaGut microbiotaBray-CurtisRRNA gene sequencesEcological indicatorsGroup of bacteriaMicrobial agingBray-Curtis distanceGene sequencesShanghai MePielou's evennessHealthy lifestyleMicrobial guildsChinese adultsChao1 indexHigher risk of type 2 diabetesHealthy lifestyle behaviorsMicrobiotaRisk of type 2 diabetesWomen's Health StudyUrban Chinese adultsCoherent groupsGuildsHigh riskLifestyle behaviorsAssociation Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium
Lee S, Ahn C, Abe S, Rahman S, Islam R, Saito E, An S, Sawada N, Shu X, Koh W, Cai H, Hozawa A, Kanemura S, Nagata C, You S, Kang D, Kanehara R, Gao Y, Yuan J, Wen W, Sugawara Y, Wada K, Chen C, Yoo K, Ahsan H, Chia K, Shin A, Kim J, Lee J, Matsuo K, Rothman N, Qiao Y, Zheng W, Boffetta P, Inoue M, Park S. Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium. Journal Of Epidemiology 2025, 35: 321-329. PMID: 40368779, PMCID: PMC12162181, DOI: 10.2188/jea.je20240362.Peer-Reviewed Original ResearchAsia Cohort ConsortiumCardiovascular disease mortalityAll-CauseHazard ratioCardiometabolic multimorbidityCohort ConsortiumPremature mortalityCardiovascular diseaseAge- and sex-adjusted hazard ratioSex-adjusted hazard ratioCardiometabolic diseasesRisk of premature mortalityCohort studyConfidence intervalsIndividual cardiometabolic diseasesProspective cohort studyBody mass indexHigh-risk conditionsPersonalized management strategiesAsian cohort studiesMultimorbiditySmoking statusIschemic heart diseaseMortality riskCox hazard regressionUrinary metabolites in association with kidney cancer risk
Al-Sayegh T, Song S, Lipworth L, Cai H, Lan Q, Gao Y, Rothman N, Cai Q, Zheng W, Shu X. Urinary metabolites in association with kidney cancer risk. Carcinogenesis 2025, 46: bgaf029. PMID: 40576378, PMCID: PMC12277705, DOI: 10.1093/carcin/bgaf029.Peer-Reviewed Original ResearchConceptsKidney cancer riskUrinary metabolitesAssociated with kidney cancerCancer riskMetabolomics studiesAssociated with kidney cancer riskKidney cancerCase-control studyMen's Health StudyKidney cancer casesKidney cancer incidenceUrine sample collectionUrine metabolitesCancer casesCancer associationCancer incidenceUrinary samplesMatched ControlsCancerLogistic regressionShanghai WomeKidneyCancer diagnosisHealth StudyUrineTopology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults
Fu J, Yu D, Zheng W, Jiang Y, Wang L, Cai H, Xia Q, Shu X, Xu W. Topology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults. Phenomics 2025, 5: 91-108. PMID: 40313606, PMCID: PMC12040777, DOI: 10.1007/s43657-024-00211-8.Peer-Reviewed Original ResearchOperational taxonomic unitsGut microbiotaDiversity of OTUsCo-abundance networksTaxonomic unitsAssociated with type 2 diabetesMicrobiota networkMicrobial networksGuild structureGut bacteriaGenus classificationMicro-ecosystemMicrobiotaGuildsShanghai MeGenusGutRelevant to diabetesStructural similarityBacteriaSparse CorrelationsChinese populationCO abundanceType 2 diabetesHuman healthReproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium.
Kazmi S, Shin A, Abe S, Islam M, Rahman M, Saito E, Cho S, Katagiri R, Merritt M, Choi J, Shu X, Sawada N, Tamakoshi A, Sakata R, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Cai H, Tsugane S, Kimura T, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D. Reproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium. Cancer Prevention Research 2025, 18: 209-221. PMID: 39846314, PMCID: PMC11961320, DOI: 10.1158/1940-6207.capr-24-0330.Peer-Reviewed Original ResearchConceptsThyroid cancer riskIncreased thyroid cancer riskAnalysis of prospective cohort studyAsia Cohort ConsortiumCancer riskProspective cohort studyCohort ConsortiumIncident thyroid cancer casesReproductive factorsAssociated with increased thyroid cancer riskCohort studyCohort-specific hazard ratiosHazard ratioConfidence intervalsPublic health strategiesYounger birth cohortsOlder ageThyroid cancer casesPooled analysisCox proportional hazards modelsBody mass indexRandom-effects modelPooled analysis of prospective cohort studiesProportional hazards modelThyroid cancer
2024
Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study.
DeMoulin D, Cai H, Vermeulen R, Zheng W, Lipworth L, Shu X. Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 1465-1474. PMID: 39145717, PMCID: PMC11530315, DOI: 10.1158/1055-9965.epi-24-0325.Peer-Reviewed Original ResearchConceptsRisk of leukemiaIncreased risk of leukemiaCancer riskStomach cancerShanghai Men's Health StudyAssociated with increased risk of leukemiaCancer associationAlcohol consumptionOccupational benzene exposureConfidence intervalsMen's Health StudyIncreased riskPopulation-based cohortJob-exposure matrixCumulative benzene exposureAssociated with increased riskMitigate cancer riskYears of follow-upKidney cancerLinear dose-response patternDose-response patternHealth StudyPotential confoundersBenzene exposureRisk association
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