2024
Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana
Gyane F, Modey E, Maya E, Bonney E, Abaidoo-Myles A, Paintsil E, Torpey K. Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana. PLOS ONE 2024, 19: e0303535. PMID: 38814956, PMCID: PMC11139324, DOI: 10.1371/journal.pone.0303535.Peer-Reviewed Original ResearchConceptsTertiary health facilityHealth facilitiesInterviewer-administered questionnaireAnalytical cross-sectional studyCervical cancer screeningCervical cancerPrevention of cervical cancerCross-sectional studyRisk factor assessmentHR-HPVAttending HIV clinicsCancer screeningHIV diagnosisLogistic regression analysisDemographic data collectionHigh-risk human papillomavirus infectionPrevalence of HR-HPVHIV clinicHigher oddsWLWHDescriptive statisticsStudy participantsHigh-risk patient groupsMultiple HPV genotypesPrevalence of HPVScreening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence
Adu-Gyamfi R, Enos J, Yeboah K, Shabanova V, Hawley N, Ogum D, Nkansah A, Paintsil E, Torpey K. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. PLOS ONE 2024, 19: e0302016. PMID: 38701070, PMCID: PMC11068165, DOI: 10.1371/journal.pone.0302016.Peer-Reviewed Original ResearchConceptsTheory-based interventionsImplementation of clinical practice guidelinesClinic visitsProvision of job aidsHealthcare workers' adherenceCluster randomized trialAvailability of guidelinesClinical practice guidelinesBehavior-based interventionsCluster-randomized studyAntiretroviral therapy sitesCardiovascular disease-related morbidityBlood pressureAIDS-related deathsIntervention facilitiesGreater Accra Region of GhanaAccra Region of GhanaGuideline adherenceHypertension screeningAntiretroviral careWorker adherenceIncidence of hypertensionHypertension riskGreater Accra RegionJob aidsClinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV
Amegashie E, Asamoah P, Ativi L, Adusei-Poku M, Bonney E, Tagoe E, Paintsil E, Torpey K, Quaye O. Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV. Experimental Biology And Medicine 2024, 249: 10059. PMID: 38628843, PMCID: PMC11020089, DOI: 10.3389/ebm.2024.10059.Peer-Reviewed Original ResearchConceptsLevels of inflammatory markersResponse to SARS-CoV-2 infectionClinical outcomesSARS-CoV-2 infectionCo-infectionInflammatory markersSARS-CoV-2HIV patients co-infectedImmune response to SARS-CoV-2 infectionCD4<sup>+</sup> countInitiation of ARTT cell exhaustionPatients co-infectedSevere outcomesAssociated with severe outcomesStudy assessed risk factorsMono-infected individualsResponse to SARS-CoV-2Respiratory tract infectionsImmunological response to SARS-CoV-2Immunological response to SARS-CoV-2 infectionAfrican American raceChronic kidney diseaseIntensive care unitPositive conversion rateEditorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce
Paintsil E. Editorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce. Current Opinion In Pediatrics 2024, 36: 133-135. PMID: 38446143, DOI: 10.1097/mop.0000000000001328.Peer-Reviewed Original ResearchConceptsPediatric infectious diseasesInternational Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward
Brackel C, Noij L, Vijverberg S, Legghe C, Maitland-van der Zee A, van Goudoever J, Buonsenso D, Munblit D, Sigfrid L, McFarland S, Anmyr L, Ashkenazi-Hoffnung L, Bellinat A, Dias N, Edwards A, Fashina T, Juraški R, Gonçalves A, Hansted E, Herczeg V, Hertting O, Jankauskaite L, Kaswandani N, Kevalas R, Krivácsy P, Lorenz M, Malone L, McVoy M, Miller D, Morrow A, Nugawela M, Oliveira C, Oliveira P, Osmanov I, Overmars I, Paintsil E, Pinto Pereira S, Prawira Y, Putri N, Ramos R, Rasche M, Ryd-Rinder M, De Rose C, Samitova E, Jovanović T, Say D, Scott J, Shachar-Lavie I, Shafran R, Shmueli E, Snipaitiene A, Stephenson T, Ténai N, Tosif S, Turkalj M, Valentini P, Vasconcelos L, Villard L, Vilser D, Hashimoto S, Terheggen-Lagro S. International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward. Pediatric Research 2024, 1-6. PMID: 38287106, DOI: 10.1038/s41390-023-03015-0.Peer-Reviewed Original ResearchCare programPost-COVID conditionsPhysical therapyPsychological supportIn-person visitsDiagnostic testsCare pathwaysLack of standardized careFramework of prioritiesGuideline developmentStandard careIn-personMultidisciplinary teamIdentified prioritiesDaily lifeCareResearch cohortManagement of childrenAggregate dataClinically treated childrenLong-term COVID-19 sequelaePatient characteristicsConcentration difficultiesReal-life managementSpecific diagnostic testsHigh prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana
Ayanful‐Torgby R, Shabanova V, Essuman A, Boafo E, Aboagye F, Al‐Mahroof Y, Amponsah J, Tetteh J, Amoah L, Paintsil E. High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana. HIV Medicine 2024, 25: 577-586. PMID: 38240173, PMCID: PMC11078607, DOI: 10.1111/hiv.13614.Peer-Reviewed Original ResearchPrevalence of impaired glucose metabolismWaist-to-hip ratioBody mass indexFasting blood sugarImpaired glucose metabolismHOMA-IRCorrelations of Waist-to-hip ratioSub-Saharan AfricaAged 6Glucose metabolismDevelopment of metabolic syndrome in adulthoodAntiretroviral treatment clinicsAssociated with fasting blood sugarWaist-to-hipHighest prevalenceAge groupsCross-sectional studyMetabolic syndrome in adulthoodInsulin resistancePathogenesis of impaired glucose metabolismOlder age groupsEastern Region of GhanaSub-SaharanSyndrome in adulthoodGlucose metabolism markersHepatitis B vaccine birth dose coverage among hepatitis B-exposed and hepatitis B-unexposed infants: evidence from the Healthy Beginning Initiative program in Benue State, Nigeria
Olakunde B, Itanyi I, Onyeka T, Paintsil E, Torpey K, Lasebikan N, Chigbu C, Ezeanolue E. Hepatitis B vaccine birth dose coverage among hepatitis B-exposed and hepatitis B-unexposed infants: evidence from the Healthy Beginning Initiative program in Benue State, Nigeria. Pan African Medical Journal 2024, 47: 67. PMID: 38681098, PMCID: PMC11055182, DOI: 10.11604/pamj.2024.47.67.40466.Peer-Reviewed Original ResearchHepB-BDAntenatal careInfants of mothersSecondary analysis of dataInstitutional deliveryHepB-BD coverageInitial programBirth dose coverageObstetric factorsSociodemographic characteristicsLess-educated mothersSecondary analysisControl of hepatitis BDose coverageAnalysis of dataPost-delivery surveysImmunization questionsHepatitis BHealthyCareHepBInfantsMothersHepatitisWomen
2023
Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience
Shabanova V, Emuren L, Gan G, Antwi S, Renner L, Amissah K, Kusah J, Lartey M, Reynolds N, Paintsil E. Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 371-380. PMID: 37643414, PMCID: PMC10617661, DOI: 10.1097/qai.0000000000003292.Peer-Reviewed Original ResearchConceptsHIV disclosure interventionsVirologic outcomesCD4 percentWeek 48HIV statusIntervention groupHIV disclosureDisclosure interventionDetectable viral loadWorld Health OrganizationAntiretroviral therapyImmunologic outcomesClinical outcomesIntervention armViral loadControl armClinical trialsTrial experienceSecondary analysisDisclosure statusHealth OrganizationCategorical variablesWeeksLinear mixed modelsBaselineHigh prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?
Kisitu G, Shabanova V, Naiga F, Nakagwa M, Kekitiinwa A, Elyanu P, Paintsil E. High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome? HIV Medicine 2023, 25: 262-275. PMID: 37879630, DOI: 10.1111/hiv.13570.Peer-Reviewed Original ResearchInternational Diabetes FederationLow high-density lipoprotein cholesterolHigh-density lipoprotein cholesterolPrevalence of MetSInsulin resistanceLipoprotein cholesterolMetabolic syndromeAdult Treatment Panel criteriaHomeostatic model assessment indexCross-sectional pilot studyFrequency of MetSModel assessment indexHOMA-IR indexOlder age groupsAge-dependent prevalenceAssociated health problemsATPIII criteriaCentral obesityBlood pressureDiabetes FederationPrimary outcomeClinical centersLifetime riskPanel criteriaHigh prevalenceAlmajiri health; a scoping review on disease, health literacy and space for participatory research
Muhammad M, Abdulsalam A, Petit-Clair F, Acquaye A, Nobles A, Fleischer B, Konkwo C, Ransome Y, Paintsil E. Almajiri health; a scoping review on disease, health literacy and space for participatory research. PLOS Global Public Health 2023, 3: e0001641. PMID: 37819921, PMCID: PMC10566680, DOI: 10.1371/journal.pgph.0001641.Peer-Reviewed Original ResearchPoor oral hygieneUrinary tract infectionCase-control studyCross-sectional studyHigh rateOral healthTract infectionsIntestinal parasitosisOral hygieneUrinary schistosomiasisHealth literacyPsychiatric disordersRabies awarenessHealth determinantsHealth outcomesHealth problemsHealth statusMale childrenOccupational injuriesSocio-ecological modelDemographic featuresInfectious diseasesStudy designMental healthN. meningitidisSupporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States
Mohammed A, Idris-Dantata H, Okwor T, Tanui P, Paintsil E, Kabwe P, Alimi Y, Tajudeen R, Mankoula W, Ilesanmi O, Balogun M, Ihekweazu C, Hornsey E, Ogbuagu O. Supporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States. Global Health Science And Practice 2023, 11: e2300121. PMID: 37903581, PMCID: PMC10615240, DOI: 10.9745/ghsp-d-23-00121.Peer-Reviewed Original ResearchA continent-wide effort and solidarity at curbing COVID-19 pandemic: the Africa task force for novel coronavirus (AFTCOR) infection prevention and control technical working group’s experience
Paintsil E, Alimi Y, Abdulaziz M, Ogbuagu O, Ogunsola F, Kessy S, Horsney E, Lee C, Brundney K, Okwor T, Kabwe P, Waheed A, Vondran A, Bigirimana R, Ilesanmi O, Nsubuga D, Raji T, Mankoula W, Ihekweazu C, Nkengasong J. A continent-wide effort and solidarity at curbing COVID-19 pandemic: the Africa task force for novel coronavirus (AFTCOR) infection prevention and control technical working group’s experience. BMC Public Health 2023, 23: 893. PMID: 37189137, PMCID: PMC10184057, DOI: 10.1186/s12889-023-15706-8.Peer-Reviewed Original ResearchConceptsInfection preventionCDC websiteNovel coronavirus disease (COVID-19) outbreakService delivery pointsCoronavirus disease (COVID-19) outbreakTask ForceIPC trainingResearch subgroupsIPC programIPC measuresHealth personnelDisease controlWorking GroupImplementation researchOutbreaks of diseaseSubgroupsPreventionCOVID-19COVID-19 pandemicTechnical Working GroupAfrica CentrePerson trainingTraining subgroupFocal personsDisease outbreaks
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original ResearchCommunity engagement in Ebola outbreaks in sub-Saharan Africa and implications for COVID-19 control: A scoping review
Frimpong S, Paintsil E. Community engagement in Ebola outbreaks in sub-Saharan Africa and implications for COVID-19 control: A scoping review. International Journal Of Infectious Diseases 2022, 126: 182-192. PMID: 36462575, DOI: 10.1016/j.ijid.2022.11.032.Peer-Reviewed Original ResearchConceptsEbola virus disease outbreakSaharan AfricaCommunity-based interventionsVirus disease outbreakCOVID-19 preventionCase seriesTreatment uptakeEmbase databasesCase detectionObservational studyCOVID-19 controlCOVID-19 pandemic preventionCase findingSurvival rateEVD outbreakFinal reviewStudy typeQuasiexperimental studyPreventionReview criteriaEbola outbreakPandemic preventionDisease outbreaksOutbreakTotal
2021
Knowledge, Attitude and Risk Perception of COVID-19 in Rural Ghana: A Viewpoint
O Frimpong S, Hilton S, Seidu M, Dorcoo-Attipoe S, Ransome Y, Paintsil E, Brayne C. Knowledge, Attitude and Risk Perception of COVID-19 in Rural Ghana: A Viewpoint. Journal Of Clinical Immunology & Microbiology 2021, 02 DOI: 10.46889/jcim.2021.2307.Peer-Reviewed Original Research
2019
Immunoepidemiology of Human Immunodeficiency
Paintsil E. Immunoepidemiology of Human Immunodeficiency. 2019, 165-178. DOI: 10.1007/978-3-030-25553-4_10.Peer-Reviewed Original ResearchAcquired Immunodeficiency SyndromeSimian immunodeficiency virusHIV-1Retrovirus human immunodeficiency virus type 1Immunodeficiency virus type 1Class I human leukocyte antigenHIV-1 diseaseHIV-2 infectionHIV-1 infectionHuman leukocyte antigenHost immune factorsHIV-1 researchImmune selection pressureHost restriction factorsVirus type 1New human hostHuman β-defensinLikelihood of transmissionEnzyme catalytic polypeptideImmunodeficiency syndromeAIDS patientsImmunodeficiency virusLeukocyte antigenHIV-2Preventative vaccine
2018
2247. Antiretrovirals Perturb Cholesterol Biosynthesis in PBMCs of HIV-Infected Individuals
Sopeyin A, Li M, Paintsil E. 2247. Antiretrovirals Perturb Cholesterol Biosynthesis in PBMCs of HIV-Infected Individuals. Open Forum Infectious Diseases 2018, 5: s664-s665. PMCID: PMC6252475, DOI: 10.1093/ofid/ofy210.1900.Peer-Reviewed Original ResearchAntiretroviral therapyMetabolic syndromeTenofovir/emtricitabine/efavirenzEffect of ARTHispanic whitesCholesterol biosynthesisZidovudine/lamivudineCase-control studyLow-density lipoprotein receptorSterol regulatory element-binding protein 2Non-Hispanic whitesDensity lipoprotein receptorRace/ethnicityAge of participantsART regimenWilcoxon rank testMetabolic derangementsViral loadHealthy controlsCardiovascular diseaseCopies/High prevalenceTherapeutic benefitSide effectsLipoprotein receptorDesire for improved disclosure, community and bonding among young adults with perinatally acquired HIV
Wang’ondu R, Samuels S, Andiman W, Paintsil E, Barakat L, Langs-Barlow A. Desire for improved disclosure, community and bonding among young adults with perinatally acquired HIV. Cogent Social Sciences 2018, 4: 1463816. DOI: 10.1080/23311886.2018.1463816.Peer-Reviewed Original ResearchHuman immunodeficiency virus programmeNumber of patientsHealth care providersYears of ageBiological mothersFear of stigmaHIV statusHIV knowledgeHIV disclosureHigh-income countriesCare providersPHIVPatientsYoung adultsBrief Resilience ScaleComprehensive interviewFeelings of isolationResilience ScaleImproved disclosureSharing of experiencesMothersAdulthoodLived experienceMedicationsHIV
2015
Predictors of trends were similar for absolute and percentage CD4+ T-lymphocytes in HIV-infected children in Ghana
Renner L, Ghebremichael M, Goka B, Lartey M, Kwara A, Paintsil E. Predictors of trends were similar for absolute and percentage CD4+ T-lymphocytes in HIV-infected children in Ghana. Journal Of Pediatric Infectious Diseases 2015, 06: 007-015. DOI: 10.3233/jpi-2011-0293.Peer-Reviewed Original ResearchPercentage CD4T lymphocytesResource-limited settingsAbsolute CD4Human immune deficiency virus (HIV) infectionWorld Health Organization (WHO) clinical stagingKorle-Bu Teaching HospitalPaediatric HIV cohortsPredictors of trendsT-lymphocyte countsHIV cohortPediatric HIVClinical stagingPatient referralTeaching hospitalRetrospective analysisVirus infectionCD4HIVPredictorsChildrenMixed modelsSubsequent valuesHospitalReferral
2014
Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition
Selvaraj S, Ghebremichael M, Li M, Foli Y, Langs-Barlow A, Ogbuagu A, Barakat L, Tubridy E, Edifor R, Lam W, Cheng Y, Paintsil E. Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition. Clinical Pharmacology & Therapeutics 2014, 96: 110-120. PMID: 24637942, PMCID: PMC4065195, DOI: 10.1038/clpt.2014.64.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsATP-Binding Cassette TransportersCase-Control StudiesDeoxyribonucleotidesDNA Polymerase gammaDNA, MitochondrialDNA-Directed DNA PolymeraseFemaleGene DosageHIV InfectionsHumansMaleMiddle AgedMitochondriaNucleic Acid Synthesis InhibitorsNucleotide Transport ProteinsNucleotidesReverse Transcriptase InhibitorsRibonucleotidesConceptsAntiretroviral therapyPeripheral blood mononuclear cellsMitochondrial toxicityBlood mononuclear cellsNegative controlMitochondrial DNA copy numberMononuclear cellsDNA copy numberMitochondrial dysfunctionHigh expression levelsPotential mechanismsGroup differencesExpression levelsPositive controlTherapyMedian valueToxicityDeoxyribonucleotide poolsCellular kinasesCassette proteinCellsDysfunctionTriphosphateControl