2025
Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?
Amegashie E, Sikeola R, Tagoe E, Paintsil E, Torpey K, Quaye O. Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution? Health Science Reports 2025, 8: e70824. PMID: 40330761, PMCID: PMC12054717, DOI: 10.1002/hsr2.70824.Peer-Reviewed Original ResearchHuman immunodeficiency virusAntiretroviral therapyMemory CD4 T cell responsesCD4 T cell responsesReducing human immunodeficiency virusOxidative stressAnimal modelsAntiretroviral therapy controlsLatent HIV infectionHIV-positive smokersT cell responsesReactive oxygen speciesCell linesT cell agingOxidation protein productsLow levels of antioxidantsIncreased oxidative stressWell-being of PLWHAntioxidant levelsHIV infectionImmunodeficiency virusOxidative stress levelsImmune overactivationOxygen speciesOverproduction of reactive oxygen speciesLipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoringIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysisSynchronicity of climate change and outbreaks of infectious diseases in children
Paintsil E. Synchronicity of climate change and outbreaks of infectious diseases in children. Current Opinion In Pediatrics 2025, 37: 113-115. PMID: 40040447, DOI: 10.1097/mop.0000000000001443.Peer-Reviewed Original ResearchP-551. The Effects of Antiretroviral Therapy on Immune Activation, Inflammation, Cellular Changes and Clinical Outcomes in Elite Controllers
Chan E, Zhou L, Emu B, Paintsil E, Barakat L. P-551. The Effects of Antiretroviral Therapy on Immune Activation, Inflammation, Cellular Changes and Clinical Outcomes in Elite Controllers. Open Forum Infectious Diseases 2025, 12: ofae631.750. PMCID: PMC11777457, DOI: 10.1093/ofid/ofae631.750.Peer-Reviewed Original ResearchEffects of antiretroviral therapyAntiretroviral therapyElite controllersViral loadIL-6Inflammatory markersImmune activationReactive oxygen speciesReactive oxygen species productionAdverse effects of ARTMitochondrial membrane potentialBenefits of antiretroviral therapyAntiretroviral Therapy ToxicitiesInflammatory markers IL-6Antiretroviral therapy groupHIV viral loadMembrane potentialCurrent published dataUtilization of antiretroviral therapyCellular inflammatory markersCompared to baselineViremic controllersClinical outcomesCRP decreaseLevels of mtDNA deletions
2024
Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study
Afrane A, Alhassan Y, Amoah L, Nyarko M, Addo-Lartey A, Paintsil E, Torpey K. Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study. BMC Infectious Diseases 2024, 24: 1144. PMID: 39394078, PMCID: PMC11470549, DOI: 10.1186/s12879-024-09974-x.Peer-Reviewed Original ResearchConceptsVirological non-suppressionAsymptomatic malaria parasitaemiaKorle Bu Teaching HospitalLow transmission areasMalaria parasitaemiaAntiretroviral therapyNon-suppressionCross-sectional studyUndetectable viral load levelsProportion of HIV-infected childrenStudy populationBackgroundHuman immunodeficiency virusHIV-infected childrenPaediatric HIV clinicMalaria preventive behaviorsResultsThe median ageViral load levelsLow-level viraemiaTransmission areasMethodsThis cross-sectional studyAsymptomatic malariaMalaria parasitemiaMalaria casesChi-square testProportion of childrenAntibiotic resistance and draft genome profiles of 10 Streptococcus pneumoniae and 3 Streptococcus pseudopneumoniae strains isolated from the nasopharynx of people living with human immunodeficiency virus in Ghana
Ativi L, Adusei-Poku M, Boateng W, Owusu-Nyantantakyi C, Danso J, Oclu A, Bortey A, Amuasi G, Tabi B, Paintsil E, Torpey K, Dayie N, Egyir B. Antibiotic resistance and draft genome profiles of 10 Streptococcus pneumoniae and 3 Streptococcus pseudopneumoniae strains isolated from the nasopharynx of people living with human immunodeficiency virus in Ghana. Microbiology Resource Announcements 2024, 13: e00505-24. PMID: 39365088, PMCID: PMC11556032, DOI: 10.1128/mra.00505-24.Peer-Reviewed Original ResearchAntimicrobial resistanceWhole-genome profilingGenomic dataAntibiotic resistanceBacteria speciesStreptococcus pneumoniae</i>Streptococcus speciesGenomic profilingHuman immunodeficiency virusSpeciesStreptococcus pneumoniaeAntimicrobial resistance surveillance effortsImmunodeficiency virusSurveillance effortsMiddle-income countriesStrainResistancePrevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana
Gyane F, Modey E, Maya E, Bonney E, Abaidoo-Myles A, Paintsil E, Torpey K. Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana. PLOS ONE 2024, 19: e0303535. PMID: 38814956, PMCID: PMC11139324, DOI: 10.1371/journal.pone.0303535.Peer-Reviewed Original ResearchConceptsTertiary health facilityHealth facilitiesInterviewer-administered questionnaireAnalytical cross-sectional studyCervical cancer screeningCervical cancerPrevention of cervical cancerCross-sectional studyRisk factor assessmentHR-HPVAttending HIV clinicsCancer screeningHIV diagnosisLogistic regression analysisDemographic data collectionHigh-risk human papillomavirus infectionPrevalence of HR-HPVHIV clinicHigher oddsWLWHDescriptive statisticsStudy participantsHigh-risk patient groupsMultiple HPV genotypesPrevalence of HPVScreening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence
Adu-Gyamfi R, Enos J, Yeboah K, Shabanova V, Hawley N, Ogum D, Nkansah A, Paintsil E, Torpey K. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. PLOS ONE 2024, 19: e0302016. PMID: 38701070, PMCID: PMC11068165, DOI: 10.1371/journal.pone.0302016.Peer-Reviewed Original ResearchConceptsTheory-based interventionsImplementation of clinical practice guidelinesClinic visitsProvision of job aidsHealthcare workers' adherenceCluster randomized trialAvailability of guidelinesClinical practice guidelinesBehavior-based interventionsCluster-randomized studyAntiretroviral therapy sitesCardiovascular disease-related morbidityBlood pressureAIDS-related deathsIntervention facilitiesGreater Accra Region of GhanaAccra Region of GhanaGuideline adherenceHypertension screeningAntiretroviral careWorker adherenceIncidence of hypertensionHypertension riskGreater Accra RegionJob aidsClinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV
Amegashie E, Asamoah P, Ativi L, Adusei-Poku M, Bonney E, Tagoe E, Paintsil E, Torpey K, Quaye O. Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV. Experimental Biology And Medicine 2024, 249: 10059. PMID: 38628843, PMCID: PMC11020089, DOI: 10.3389/ebm.2024.10059.Peer-Reviewed Original ResearchConceptsLevels of inflammatory markersResponse to SARS-CoV-2 infectionClinical outcomesSARS-CoV-2 infectionCo-infectionInflammatory markersSARS-CoV-2HIV patients co-infectedImmune response to SARS-CoV-2 infectionCD4<sup>+</sup> countInitiation of ARTT cell exhaustionPatients co-infectedSevere outcomesAssociated with severe outcomesStudy assessed risk factorsMono-infected individualsResponse to SARS-CoV-2Respiratory tract infectionsImmunological response to SARS-CoV-2Immunological response to SARS-CoV-2 infectionAfrican American raceChronic kidney diseaseIntensive care unitPositive conversion rateEditorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce
Paintsil E. Editorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce. Current Opinion In Pediatrics 2024, 36: 133-135. PMID: 38446143, DOI: 10.1097/mop.0000000000001328.Peer-Reviewed Original ResearchConceptsPediatric infectious diseasesInternational Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward
Brackel C, Noij L, Vijverberg S, Legghe C, Maitland-van der Zee A, van Goudoever J, Buonsenso D, Munblit D, Sigfrid L, McFarland S, Anmyr L, Ashkenazi-Hoffnung L, Bellinat A, Dias N, Edwards A, Fashina T, Juraški R, Gonçalves A, Hansted E, Herczeg V, Hertting O, Jankauskaite L, Kaswandani N, Kevalas R, Krivácsy P, Lorenz M, Malone L, McVoy M, Miller D, Morrow A, Nugawela M, Oliveira C, Oliveira P, Osmanov I, Overmars I, Paintsil E, Pinto Pereira S, Prawira Y, Putri N, Ramos R, Rasche M, Ryd-Rinder M, De Rose C, Samitova E, Jovanović T, Say D, Scott J, Shachar-Lavie I, Shafran R, Shmueli E, Snipaitiene A, Stephenson T, Ténai N, Tosif S, Turkalj M, Valentini P, Vasconcelos L, Villard L, Vilser D, Hashimoto S, Terheggen-Lagro S. International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward. Pediatric Research 2024, 96: 319-324. PMID: 38287106, DOI: 10.1038/s41390-023-03015-0.Peer-Reviewed Original ResearchCare programPost-COVID conditionsPhysical therapyPsychological supportIn-person visitsDiagnostic testsCare pathwaysLack of standardized careFramework of prioritiesGuideline developmentStandard careIn-personMultidisciplinary teamIdentified prioritiesDaily lifeCareResearch cohortManagement of childrenAggregate dataClinically treated childrenLong-term COVID-19 sequelaePatient characteristicsConcentration difficultiesReal-life managementSpecific diagnostic testsHigh prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana
Ayanful‐Torgby R, Shabanova V, Essuman A, Boafo E, Aboagye F, Al‐Mahroof Y, Amponsah J, Tetteh J, Amoah L, Paintsil E. High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana. HIV Medicine 2024, 25: 577-586. PMID: 38240173, PMCID: PMC11078607, DOI: 10.1111/hiv.13614.Peer-Reviewed Original ResearchPrevalence of impaired glucose metabolismWaist-to-hip ratioBody mass indexFasting blood sugarImpaired glucose metabolismHOMA-IRCorrelations of Waist-to-hip ratioSub-Saharan AfricaAged 6Glucose metabolismDevelopment of metabolic syndrome in adulthoodAntiretroviral treatment clinicsAssociated with fasting blood sugarWaist-to-hipHighest prevalenceAge groupsCross-sectional studyMetabolic syndrome in adulthoodInsulin resistancePathogenesis of impaired glucose metabolismOlder age groupsEastern Region of GhanaSub-SaharanSyndrome in adulthoodGlucose metabolism markersHepatitis B vaccine birth dose coverage among hepatitis B-exposed and hepatitis B-unexposed infants: evidence from the Healthy Beginning Initiative program in Benue State, Nigeria
Olakunde B, Itanyi I, Onyeka T, Paintsil E, Torpey K, Lasebikan N, Chigbu C, Ezeanolue E. Hepatitis B vaccine birth dose coverage among hepatitis B-exposed and hepatitis B-unexposed infants: evidence from the Healthy Beginning Initiative program in Benue State, Nigeria. Pan African Medical Journal 2024, 47: 67. PMID: 38681098, PMCID: PMC11055182, DOI: 10.11604/pamj.2024.47.67.40466.Peer-Reviewed Original ResearchHepB-BDAntenatal careInfants of mothersSecondary analysis of dataInstitutional deliveryHepB-BD coverageInitial programBirth dose coverageObstetric factorsSociodemographic characteristicsLess-educated mothersSecondary analysisControl of hepatitis BDose coverageAnalysis of dataPost-delivery surveysImmunization questionsHepatitis BHealthyCareHepBInfantsMothersHepatitisWomen
2023
Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience
Shabanova V, Emuren L, Gan G, Antwi S, Renner L, Amissah K, Kusah J, Lartey M, Reynolds N, Paintsil E. Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 371-380. PMID: 37643414, PMCID: PMC10617661, DOI: 10.1097/qai.0000000000003292.Peer-Reviewed Original ResearchConceptsHIV disclosure interventionsVirologic outcomesCD4 percentWeek 48HIV statusIntervention groupHIV disclosureDisclosure interventionDetectable viral loadWorld Health OrganizationAntiretroviral therapyImmunologic outcomesClinical outcomesIntervention armViral loadControl armClinical trialsTrial experienceSecondary analysisDisclosure statusHealth OrganizationCategorical variablesWeeksLinear mixed modelsBaselineHigh prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?
Kisitu G, Shabanova V, Naiga F, Nakagwa M, Kekitiinwa A, Elyanu P, Paintsil E. High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome? HIV Medicine 2023, 25: 262-275. PMID: 37879630, DOI: 10.1111/hiv.13570.Peer-Reviewed Original ResearchInternational Diabetes FederationLow high-density lipoprotein cholesterolHigh-density lipoprotein cholesterolPrevalence of MetSInsulin resistanceLipoprotein cholesterolMetabolic syndromeAdult Treatment Panel criteriaHomeostatic model assessment indexCross-sectional pilot studyFrequency of MetSModel assessment indexHOMA-IR indexOlder age groupsAge-dependent prevalenceAssociated health problemsATPIII criteriaCentral obesityBlood pressureDiabetes FederationPrimary outcomeClinical centersLifetime riskPanel criteriaHigh prevalenceAlmajiri health; a scoping review on disease, health literacy and space for participatory research
Muhammad M, Abdulsalam A, Petit-Clair F, Acquaye A, Nobles A, Fleischer B, Konkwo C, Ransome Y, Paintsil E. Almajiri health; a scoping review on disease, health literacy and space for participatory research. PLOS Global Public Health 2023, 3: e0001641. PMID: 37819921, PMCID: PMC10566680, DOI: 10.1371/journal.pgph.0001641.Peer-Reviewed Original ResearchPoor oral hygieneUrinary tract infectionCase-control studyCross-sectional studyHigh rateOral healthTract infectionsIntestinal parasitosisOral hygieneUrinary schistosomiasisHealth literacyPsychiatric disordersRabies awarenessHealth determinantsHealth outcomesHealth problemsHealth statusMale childrenOccupational injuriesSocio-ecological modelDemographic featuresInfectious diseasesStudy designMental healthN. meningitidisSupporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States
Mohammed A, Idris-Dantata H, Okwor T, Tanui P, Paintsil E, Kabwe P, Alimi Y, Tajudeen R, Mankoula W, Ilesanmi O, Balogun M, Ihekweazu C, Hornsey E, Ogbuagu O. Supporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States. Global Health Science And Practice 2023, 11: e2300121. PMID: 37903581, PMCID: PMC10615240, DOI: 10.9745/ghsp-d-23-00121.Peer-Reviewed Original ResearchA continent-wide effort and solidarity at curbing COVID-19 pandemic: the Africa task force for novel coronavirus (AFTCOR) infection prevention and control technical working group’s experience
Paintsil E, Alimi Y, Abdulaziz M, Ogbuagu O, Ogunsola F, Kessy S, Horsney E, Lee C, Brundney K, Okwor T, Kabwe P, Waheed A, Vondran A, Bigirimana R, Ilesanmi O, Nsubuga D, Raji T, Mankoula W, Ihekweazu C, Nkengasong J. A continent-wide effort and solidarity at curbing COVID-19 pandemic: the Africa task force for novel coronavirus (AFTCOR) infection prevention and control technical working group’s experience. BMC Public Health 2023, 23: 893. PMID: 37189137, PMCID: PMC10184057, DOI: 10.1186/s12889-023-15706-8.Peer-Reviewed Original ResearchConceptsInfection preventionCDC websiteNovel coronavirus disease (COVID-19) outbreakService delivery pointsCoronavirus disease (COVID-19) outbreakTask ForceIPC trainingResearch subgroupsIPC programIPC measuresHealth personnelDisease controlWorking GroupImplementation researchOutbreaks of diseaseSubgroupsPreventionCOVID-19COVID-19 pandemicTechnical Working GroupAfrica CentrePerson trainingTraining subgroupFocal personsDisease outbreaks
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original Research
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