Elijah Paintsil, FAAP, MD
Professor Adjunct in PediatricsCards
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Professor of Pediatrics (Infectious Diseases), Pediatrics
Professor, Epidemiology of Microbial Diseases
Professor of Pharmacology, Molecular Medicine, Pharmacology, and Physiology
Professor of Management, School of Management
Contact Info
Pediatric Infectious Diseases
PO Box 208064
New Haven, CT 06520-8064
United States
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Professor of Pediatrics (Infectious Diseases), Pediatrics
Professor, Epidemiology of Microbial Diseases
Professor of Pharmacology, Molecular Medicine, Pharmacology, and Physiology
Professor of Management, School of Management
Contact Info
Pediatric Infectious Diseases
PO Box 208064
New Haven, CT 06520-8064
United States
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Professor of Pediatrics (Infectious Diseases), Pediatrics
Professor, Epidemiology of Microbial Diseases
Professor of Pharmacology, Molecular Medicine, Pharmacology, and Physiology
Professor of Management, School of Management
Contact Info
Pediatric Infectious Diseases
PO Box 208064
New Haven, CT 06520-8064
United States
About
Titles
Professor Adjunct in Pediatrics
Affiliated Faculty, Yale Institute for Global Health; Professor of Pediatrics (Infectious Diseases), Pediatrics; Professor, Epidemiology of Microbial Diseases; Professor of Pharmacology, Molecular Medicine, Pharmacology, and Physiology; Professor of Management, School of Management
Biography
The Paintsil laboratory focuses on increasing our understanding of the host determinants of individual differences in response to antiretroviral therapy; biomarkers and pathogenesis of increasing incidence of cancers in HIV treatment-experienced individuals.
Appointments
Pharmacology
ProfessorSecondarySchool of Management
ProfessorSecondary
Other Departments & Organizations
- African Studies
- Cancer Prevention and Control
- Center for Interdisciplinary Research on AIDS
- Global Health Studies
- Office of Global Health Education
- Pediatric Immunology Program
- Pediatric Infectious Diseases Consultation Program
- Pediatrics
- Pharmacology
- School of Management
- Virology Laboratories
- Yale Cancer Center
- Yale Institute for Global Health
- Yale Ventures
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
Education & Training
- Fellow
- Yale University School of Medicine (2005)
- Resident
- Lincoln Medical Center, Bronx, NY (2002)
- Intern
- Lincoln Medical Center, Bronx, NY (2000)
- Intern
- Korle-Bu Teaching Hospital, Accra, Ghana (1994)
- MD
- Ghana Medical School
Research
Overview
Our research focuses on understanding the determinants of individual differences in response to antiretroviral therapy (ART) (e.g., virologic suppression, resistance evolution, and clinical toxicities). This research interest was fostered by an NIH career development award (K08) from 2008 to 2013. During this period, we studied various host determinants such as individual differences in the intracellular concentrations of antiretroviral drugs, cellular kinases involved in the phosphorylation of nucleoside analogs, and ATP-binding Cassette (ABC) transport proteins, and effect of treatment on mitochondrial function. These findings challenged the existing paradigm that only nucleoside reverse transcriptase inhibitors (NRTIs) caused mitochondrial dysfunction through inhibition of mitochondrial DNA polymerase gamma (Pol-ɣ) – the “Pol-ɣ hypothesis.” The studies identified other Pol-ɣ-independent pathways that can lead to mitochondrial dysfunction such as depletion of nucleotide pool and mitochondria DNA mutations. This led to the development of the novel hypothesis that ART causes mitochondrial dysfunction through both pol-γ-dependent and pol-γ-independent mechanisms, which results in a decrease in cellular dNTP and rNTP pools and genomic instability resulting in clinical toxicity and aging-related disorders in HIV-infected.
Medical Research Interests
ORCID
0000-0002-8283-4564
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Carlos R Oliveira, MD, PhD
Veronika Shabanova, PhD
Christine Miller, DO
Cynthia Brandt, MD, MPH
Geliang Gan, MPH, PhD
Linda Niccolai, PhD
Ghana
Pediatrics
Publications
2024
Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study
Afrane A, Alhassan Y, Amoah L, Nyarko M, Addo-Lartey A, Paintsil E, Torpey K. Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study. BMC Infectious Diseases 2024, 24: 1144. PMID: 39394078, PMCID: PMC11470549, DOI: 10.1186/s12879-024-09974-x.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsVirological non-suppressionAsymptomatic malaria parasitaemiaKorle Bu Teaching HospitalLow transmission areasMalaria parasitaemiaAntiretroviral therapyNon-suppressionCross-sectional studyUndetectable viral load levelsProportion of HIV-infected childrenStudy populationBackgroundHuman immunodeficiency virusHIV-infected childrenPaediatric HIV clinicMalaria preventive behaviorsResultsThe median ageViral load levelsLow-level viraemiaTransmission areasMethodsThis cross-sectional studyAsymptomatic malariaMalaria parasitemiaMalaria casesChi-square testProportion of childrenAntibiotic resistance and draft genome profiles of 10 Streptococcus pneumoniae and 3 Streptococcus pseudopneumoniae strains isolated from the nasopharynx of people living with human immunodeficiency virus in Ghana.
Ativi L, Adusei-Poku M, Boateng W, Owusu-Nyantantakyi C, Kwesi Danso J, Oclu A, Bortey A, Rabbi Amuasi G, Kofi Adu Tabi B, Paintsil E, Torpey K, Dzifa Dayie N, Egyir B. Antibiotic resistance and draft genome profiles of 10 Streptococcus pneumoniae and 3 Streptococcus pseudopneumoniae strains isolated from the nasopharynx of people living with human immunodeficiency virus in Ghana. Microbiology Resource Announcements 2024, e0050524. PMID: 39365088, DOI: 10.1128/mra.00505-24.Peer-Reviewed Original ResearchConceptsAntimicrobial resistanceWhole-genome profilingGenomic dataAntibiotic resistanceBacteria speciesStreptococcus pneumoniae</i>Streptococcus speciesGenomic profilingHuman immunodeficiency virusSpeciesStreptococcus pneumoniaeAntimicrobial resistance surveillance effortsImmunodeficiency virusSurveillance effortsMiddle-income countriesStrainResistancePrevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana
Gyane F, Modey E, Maya E, Bonney E, Abaidoo-Myles A, Paintsil E, Torpey K. Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana. PLOS ONE 2024, 19: e0303535. PMID: 38814956, PMCID: PMC11139324, DOI: 10.1371/journal.pone.0303535.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTertiary health facilityHealth facilitiesInterviewer-administered questionnaireAnalytical cross-sectional studyCervical cancer screeningCervical cancerPrevention of cervical cancerCross-sectional studyRisk factor assessmentHR-HPVAttending HIV clinicsCancer screeningHIV diagnosisLogistic regression analysisDemographic data collectionHigh-risk human papillomavirus infectionPrevalence of HR-HPVHIV clinicHigher oddsWLWHDescriptive statisticsStudy participantsHigh-risk patient groupsMultiple HPV genotypesPrevalence of HPVScreening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence
Adu-Gyamfi R, Enos J, Yeboah K, Shabanova V, Hawley N, Ogum D, Nkansah A, Paintsil E, Torpey K. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. PLOS ONE 2024, 19: e0302016. PMID: 38701070, PMCID: PMC11068165, DOI: 10.1371/journal.pone.0302016.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTheory-based interventionsImplementation of clinical practice guidelinesClinic visitsProvision of job aidsHealthcare workers' adherenceCluster randomized trialAvailability of guidelinesClinical practice guidelinesBehavior-based interventionsCluster-randomized studyAntiretroviral therapy sitesCardiovascular disease-related morbidityBlood pressureAIDS-related deathsIntervention facilitiesGreater Accra Region of GhanaAccra Region of GhanaGuideline adherenceHypertension screeningAntiretroviral careWorker adherenceIncidence of hypertensionHypertension riskGreater Accra RegionJob aidsClinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV
Amegashie E, Asamoah P, Ativi L, Adusei-Poku M, Bonney E, Tagoe E, Paintsil E, Torpey K, Quaye O. Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV. Experimental Biology And Medicine 2024, 249: 10059. PMID: 38628843, PMCID: PMC11020089, DOI: 10.3389/ebm.2024.10059.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLevels of inflammatory markersResponse to SARS-CoV-2 infectionClinical outcomesSARS-CoV-2 infectionCo-infectionInflammatory markersSARS-CoV-2HIV patients co-infectedImmune response to SARS-CoV-2 infectionCD4<sup>+</sup> countInitiation of ARTT cell exhaustionPatients co-infectedSevere outcomesAssociated with severe outcomesStudy assessed risk factorsMono-infected individualsResponse to SARS-CoV-2Respiratory tract infectionsImmunological response to SARS-CoV-2Immunological response to SARS-CoV-2 infectionAfrican American raceChronic kidney diseaseIntensive care unitPositive conversion rateEditorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce
Paintsil E. Editorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce. Current Opinion In Pediatrics 2024, 36: 133-135. PMID: 38446143, DOI: 10.1097/mop.0000000000001328.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPediatric infectious diseasesInternational Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward
Brackel C, Noij L, Vijverberg S, Legghe C, Maitland-van der Zee A, van Goudoever J, Buonsenso D, Munblit D, Sigfrid L, McFarland S, Anmyr L, Ashkenazi-Hoffnung L, Bellinat A, Dias N, Edwards A, Fashina T, Juraški R, Gonçalves A, Hansted E, Herczeg V, Hertting O, Jankauskaite L, Kaswandani N, Kevalas R, Krivácsy P, Lorenz M, Malone L, McVoy M, Miller D, Morrow A, Nugawela M, Oliveira C, Oliveira P, Osmanov I, Overmars I, Paintsil E, Pinto Pereira S, Prawira Y, Putri N, Ramos R, Rasche M, Ryd-Rinder M, De Rose C, Samitova E, Jovanović T, Say D, Scott J, Shachar-Lavie I, Shafran R, Shmueli E, Snipaitiene A, Stephenson T, Ténai N, Tosif S, Turkalj M, Valentini P, Vasconcelos L, Villard L, Vilser D, Hashimoto S, Terheggen-Lagro S. International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward. Pediatric Research 2024, 96: 319-324. PMID: 38287106, DOI: 10.1038/s41390-023-03015-0.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCare programPost-COVID conditionsPhysical therapyPsychological supportIn-person visitsDiagnostic testsCare pathwaysLack of standardized careFramework of prioritiesGuideline developmentStandard careIn-personMultidisciplinary teamIdentified prioritiesDaily lifeCareResearch cohortManagement of childrenAggregate dataClinically treated childrenLong-term COVID-19 sequelaePatient characteristicsConcentration difficultiesReal-life managementSpecific diagnostic testsHigh prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana
Ayanful‐Torgby R, Shabanova V, Essuman A, Boafo E, Aboagye F, Al‐Mahroof Y, Amponsah J, Tetteh J, Amoah L, Paintsil E. High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana. HIV Medicine 2024, 25: 577-586. PMID: 38240173, PMCID: PMC11078607, DOI: 10.1111/hiv.13614.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPrevalence of impaired glucose metabolismWaist-to-hip ratioBody mass indexFasting blood sugarImpaired glucose metabolismHOMA-IRCorrelations of Waist-to-hip ratioSub-Saharan AfricaAged 6Glucose metabolismDevelopment of metabolic syndrome in adulthoodAntiretroviral treatment clinicsAssociated with fasting blood sugarWaist-to-hipHighest prevalenceAge groupsCross-sectional studyMetabolic syndrome in adulthoodInsulin resistancePathogenesis of impaired glucose metabolismOlder age groupsEastern Region of GhanaSub-SaharanSyndrome in adulthoodGlucose metabolism markersHepatitis B vaccine birth dose coverage among hepatitis B-exposed and hepatitis B-unexposed infants: evidence from the Healthy Beginning Initiative program in Benue State, Nigeria
Olakunde B, Itanyi I, Onyeka T, Paintsil E, Torpey K, Lasebikan N, Chigbu C, Ezeanolue E. Hepatitis B vaccine birth dose coverage among hepatitis B-exposed and hepatitis B-unexposed infants: evidence from the Healthy Beginning Initiative program in Benue State, Nigeria. Pan African Medical Journal 2024, 47: 67. PMID: 38681098, PMCID: PMC11055182, DOI: 10.11604/pamj.2024.47.67.40466.Peer-Reviewed Original ResearchAltmetricConceptsHepB-BDAntenatal careInfants of mothersSecondary analysis of dataInstitutional deliveryHepB-BD coverageInitial programBirth dose coverageObstetric factorsSociodemographic characteristicsLess-educated mothersSecondary analysisControl of hepatitis BDose coverageAnalysis of dataPost-delivery surveysImmunization questionsHepatitis BHealthyCareHepBInfantsMothersHepatitisWomen
2023
Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience
Shabanova V, Emuren L, Gan G, Antwi S, Renner L, Amissah K, Kusah J, Lartey M, Reynolds N, Paintsil E. Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 371-380. PMID: 37643414, PMCID: PMC10617661, DOI: 10.1097/qai.0000000000003292.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHIV disclosure interventionsVirologic outcomesCD4 percentWeek 48HIV statusIntervention groupHIV disclosureDisclosure interventionDetectable viral loadWorld Health OrganizationAntiretroviral therapyImmunologic outcomesClinical outcomesIntervention armViral loadControl armClinical trialsTrial experienceSecondary analysisDisclosure statusHealth OrganizationCategorical variablesWeeksLinear mixed modelsBaseline
Academic Achievements & Community Involvement
activity Infectious Diseases Research
ResearchDetails01/01/2009 - PresentSao Paulo, Sao Paulo, BrazilAbstract/SynopsisCapacity building
honor American Academy of Pediatrics, Fellow
UnknownDetails01/01/2003United Stateshonor Infectious Diseases Society of America (IDSA), Member
UnknownDetails01/01/2003United Stateshonor Pediatric Infectious Diseases Society, Member
UnknownDetails01/01/2002United States
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- December 20, 2022
Million Dollar Endowment Helps Bring Global Biomedical Leadership Program to Yale School of Medicine
- November 08, 2022
Alumni Spotlight: Nanlesta Pilgrim, PhD, MPH ’07 (Social & Behavioral Sciences), BA ’04
- April 05, 2022
100 Years of Pediatrics at Yale
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Contacts
Pediatric Infectious Diseases
PO Box 208064
New Haven, CT 06520-8064
United States