David Labaree, PhD
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Radiology & Biomedical Imaging
PO Box 208042, Tompkin's East 2
New Haven, CT 06520-8042
United States
About
Titles
Associate Research Scientist in Radiology and Biomedical Imaging
Appointments
Radiology & Biomedical Imaging
Associate Research ScientistPrimary
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Education & Training
- PhD
- University of Maryland/College Park (1991)
- BA
- Connecticut College (1982)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Labaree's published research.
Publications Timeline
A big-picture view of David Labaree's research output by year.
Richard Carson, PhD
Nabeel Nabulsi, PhD
Jean-Dominique Gallezot, PhD
Jason Cai, PhD
Soheila Najafzadeh
Jie Tong, PhD
29Publications
235Citations
Publications
2024
First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
Drake L, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery P, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer A, Gallezot J, Carson R, Cai Z, Huang Y. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266470. PMID: 38360052, PMCID: PMC10924160, DOI: 10.2967/jnumed.123.266470.Peer-Reviewed Original ResearchAltmetricConceptsFirst-in-human studyPlasma free fractionTime-activity curvesCentrum semiovaleNonhuman primate's resultsFirst-in-humanFree fractionNondisplaceable binding potentialRegional time-activity curvesLow nonspecific uptakeRegional distribution volumesHigh-resolution research tomograph scannerTest-retest reproducibilityCerebral blood flowSynaptic vesicle glycoprotein 2AHealthy volunteersArterial input functionNonspecific uptakePET imaging probeDistribution volumeSynapse densityIndividual MR imagesHighest specific bindingMR imagingPET imaging
2022
P-304 The synthesis and bioevaluation of a novel and brain penetrable PARP1 tracer [18F]Pamiparib in rodents and nonhuman primates
Tong J, Chen B, Gu J, Alluri S, Zheng M, Zheng C, Felchner Z, Gao H, Zhang L, Kapinos M, Labaree D, Ropchan J, Nabulsi N, Carson R, Huang Y, Cai Z. P-304 The synthesis and bioevaluation of a novel and brain penetrable PARP1 tracer [18F]Pamiparib in rodents and nonhuman primates. Nuclear Medicine And Biology 2022, 108: s214-s215. DOI: 10.1016/s0969-8051(22)00440-1.Peer-Reviewed Original ResearchCitationsP-303 Synthesis and preclinical evaluation of PD-L1 PET tracer [18F]FDHPA in mice
Tong J, Chen B, Alluri S, Gu J, Zheng M, Zheng C, Felchner Z, Gao H, Zhang L, Kapinos M, Labaree D, Ropchan J, Nabulsi N, Marquez-Nostra B, Carson R, Huang Y, Cai Z. P-303 Synthesis and preclinical evaluation of PD-L1 PET tracer [18F]FDHPA in mice. Nuclear Medicine And Biology 2022, 108: s214. DOI: 10.1016/s0969-8051(22)00439-5.Peer-Reviewed Original ResearchCitations
2014
Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities
Zhang J, Labaree D, Hochberg R. Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities. Chinese Chemical Letters 2014, 25: 567-570. DOI: 10.1016/j.cclet.2014.01.015.Peer-Reviewed Original ResearchCitations
2013
ChemInform Abstract: Synthesis and Evaluation of 4‐(Substituted styryl/alkenyl)‐3,5‐bis(4‐hydroxyphenyl)‐isoxazoles as Ligands for the Estrogen Receptor.
Haddad T, Gershman R, Dilis R, Labaree D, Hochberg R, Hanson R. ChemInform Abstract: Synthesis and Evaluation of 4‐(Substituted styryl/alkenyl)‐3,5‐bis(4‐hydroxyphenyl)‐isoxazoles as Ligands for the Estrogen Receptor. ChemInform 2013, 44: no-no. DOI: 10.1002/chin.201301119.Peer-Reviewed Original Research
2012
ChemInform Abstract: Synthesis and Evaluation of 17α‐E‐20‐(Heteroaryl)norpregn‐1,3,5 (10),20‐tetraene‐3,17β‐diols [17α‐(Heteroaryl)vinyl Estradiols] as Ligands for the Estrogen Receptor‐α Ligand Binding Domain (ERα‐LBD).
Olmsted S, Tongcharoensirikul P, McCaskill E, Gandiaga K, Labaree D, Hochberg R, Hanson R. ChemInform Abstract: Synthesis and Evaluation of 17α‐E‐20‐(Heteroaryl)norpregn‐1,3,5 (10),20‐tetraene‐3,17β‐diols [17α‐(Heteroaryl)vinyl Estradiols] as Ligands for the Estrogen Receptor‐α Ligand Binding Domain (ERα‐LBD). ChemInform 2012, 43: no-no. DOI: 10.1002/chin.201242199.Peer-Reviewed Original ResearchSynthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor
Haddad T, Gershman R, Dilis R, Labaree D, Hochberg RB, Hanson RN. Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor. Bioorganic & Medicinal Chemistry Letters 2012, 22: 5999-6003. PMID: 22906893, PMCID: PMC3444814, DOI: 10.1016/j.bmcl.2012.06.097.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsSynthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists
Hanson RN, Hua E, Hendricks JA, Labaree D, Hochberg RB. Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists. Bioorganic & Medicinal Chemistry 2012, 20: 3768-3780. PMID: 22608920, PMCID: PMC3581310, DOI: 10.1016/j.bmc.2012.04.041.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSynthetic strategyNew compoundsERα-LBDPotential drug delivery systemPrevious synthetic studiesSeries of compoundsDrug delivery systemsClass of compoundsSynthetic methodTerminal groupsFacile accessSynthetic studiesDrug conjugationSpecific structural featuresCompetitive ligandCompoundsSteroidal agonistsDelivery systemRepresentative scaffoldsStructural featuresERβ-LBDSubtype selectivityActive groupAnaloguesScaffoldsTargeting the estrogen receptor with metal-carbonyl derivatives of estradiol
Hanson RN, Kirss R, McCaskill E, Hua E, Tongcharoensirikul P, Olmsted SL, Labaree D, Hochberg RB. Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol. Bioorganic & Medicinal Chemistry Letters 2012, 22: 1670-1673. PMID: 22277281, PMCID: PMC3274643, DOI: 10.1016/j.bmcl.2011.12.111.Peer-Reviewed Original ResearchCitations
2010
[11C]GR103545: novel one-pot radiosynthesis with high specific activity
Nabulsi NB, Zheng MQ, Ropchan J, Labaree D, Ding YS, Blumberg L, Huang Y. [11C]GR103545: novel one-pot radiosynthesis with high specific activity. Nuclear Medicine And Biology 2010, 38: 215-221. PMID: 21315277, DOI: 10.1016/j.nucmedbio.2010.08.014.Peer-Reviewed Original ResearchCitations
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Radiology & Biomedical Imaging
PO Box 208042, Tompkin's East 2
New Haven, CT 06520-8042
United States