Caroline Hendry, PhD
Research ScientistCards
Appointments
Additional Titles
Scientific Director; Advisor to the Chair, Genetics
Director, Office for Strategic Research Development, Genetics
Contact Info
Appointments
Additional Titles
Scientific Director; Advisor to the Chair, Genetics
Director, Office for Strategic Research Development, Genetics
Contact Info
Appointments
Additional Titles
Scientific Director; Advisor to the Chair, Genetics
Director, Office for Strategic Research Development, Genetics
Contact Info
About
Titles
Research Scientist
Scientific Director; Advisor to the Chair, Genetics; Director, Office for Strategic Research Development, Genetics
Biography
Caroline is the Scientific Director and Advisor to the Chair of Genetics at Yale School of Medicine. Caroline was born in Brisbane, Australia and earned her undergraduate degree in Genetics at the University of Queensland, Australia. She earned her PhD under Prof Melissa Little at the Institute for Molecular Bioscience and went on to do a post-doc with Prof Ihor Lemishka at the Mount Sinai School of Medicine, NY, specialising in stem cells and reprogramming. Following her postdoc, Caroline moved to Cambridge, UK, where she took on a new role as Reviews Editor for the journal Development, covering the stem cells and regeneration fields.
Caroline was recruited to Yale in 2018 where she is responsible for increasing scientific impact and discovery in the Department of Genetics, bridging both basic and clinical research. To support this goal, Caroline maintains a strong leadership position in the Department of Genetics and also leads an Office for Strategic Research Development comprised of additional faculty and trainees.
A key aspect of the role is to foster interactions with Genetics faculty and other key stakeholders in genetics and genomics to develop and implement the scientific vision of the department and create strategic collaborations across Yale School of Medicine, Yale University, and industry. The role also provides leadership in driving new projects and programs to further the Department's mission and to translate existing research into new opportunities for growth.
Appointments
Genetics
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- MBA
- Yale School of Management (2026)
- Postdoctoral Scientist
- Mount Sinai School of Medicine (2012)
- PhD
- Institute for Molecular Bioscience, Molecular Biology (2010)
- BSc (Hon)
- University of Queensland, Genetics (2006)
Research
Research at a Glance
Publications Timeline
Publications
2022
The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
Miao L, Tang Y, Bonneau AR, Chan SH, Kojima ML, Pownall ME, Vejnar CE, Gao F, Krishnaswamy S, Hendry CE, Giraldez AJ. The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell 2022, 82: 986-1002.e9. PMID: 35182480, PMCID: PMC9327391, DOI: 10.1016/j.molcel.2022.01.024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenome activationChromatin openingTranscription factorsPioneer factor activityDifferent transcription factorsChromatin reprogrammingPioneer factorsNucleosome positionsActive enhancersIndividual genesCore histonesTriple mutantGene activationTF inputsDevelopmental transitionsSequence contextCell typesFactor activityHistonesPioneering activityEnhancerActivationSequence of eventsPou5f3ChromatinPrdm6 controls heart development by regulating neural crest cell differentiation and migration
Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight 2022, 7: e156046. PMID: 35108221, PMCID: PMC8876496, DOI: 10.1172/jci.insight.156046.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCardiac NCCNeural crest cell fateNeural crest cell differentiationSingle-cell RNA-seq analysisRNA-seq analysisDorsal neural tubeG1-S progressionFate-mapping approachCNCC migrationSpecification genesH4K20 monomethylationCell fateTranscriptomic analysisEpigenetic modifiersHeart developmentRegulated networkTranscript levelsKey regulatorMolecular mechanismsCell differentiationNeural tubePRDM6Ductus arteriosusPotential targetDifferentiation
2017
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.
Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D'Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MYR, Zhu K, Wang S, Roussos P, Schadt EE, Pandey G, Chang R, Quertermous T, Lemischka I. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell 2017, 20: 518-532.e9. PMID: 28017796, DOI: 10.1016/j.stem.2016.11.005.Peer-Reviewed Original Research
2013
Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors.
Hendry CE, Vanslambrouck JM, Ineson J, Suhaimi N, Takasato M, Rae F, Little MH. Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. Journal Of The American Society Of Nephrology : JASN 2013, 24: 1424-34. PMID: 23766537, PMCID: PMC3752949, DOI: 10.1681/ASN.2012121143.Peer-Reviewed Original ResearchInduction of a hemogenic program in mouse fibroblasts.
Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma'ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell 2013, 13: 205-18. PMID: 23770078, PMCID: PMC3735774, DOI: 10.1016/j.stem.2013.05.024.Peer-Reviewed Original Research
2012
Reprogramming the kidney: a novel approach for regeneration.
Hendry CE, Little MH. Reprogramming the kidney: a novel approach for regeneration. Kidney International 2012, 82: 138-46. PMID: 22437414, DOI: 10.1038/ki.2012.68.Peer-Reviewed Original Research
2011
Defining and redefining the nephron progenitor population.
Hendry C, Rumballe B, Moritz K, Little MH. Defining and redefining the nephron progenitor population. Pediatric Nephrology (Berlin, Germany) 2011, 26: 1395-406. PMID: 21229268, PMCID: PMC3189495, DOI: 10.1007/s00467-010-1750-4.Peer-Reviewed Original Research
2009
Stem cell options for kidney disease.
Hopkins C, Li J, Rae F, Little MH. Stem cell options for kidney disease. J Pathol 2009, 217: 265-81. PMID: 19058290, DOI: 10.1002/path.2477.Peer-Reviewed Original Research
News
News
- September 10, 2024
NIH Recognizes Yale’s Expertise in the Genetics of Rare Diseases
- February 10, 2022
Yale Scientists Identify a Gene That Can Repair Congenital Heart Defects
- August 27, 2021
Collective Efforts to Increase Diversity, Equity, and Inclusion in the Genetics Department Make Steady Progress
- February 16, 2021
Diverse Junior Scientists Display Their Talents and Learn to Navigate Academia