Ashwani Kumar, PhD
Associate Research ScientistCards
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Research
Publications
2026
APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection
Pell J, Tanvir E, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Al Chaar S, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, De Kumar B, Smithson S, Song W, He J, Chong A, Pober J, Somlo S, Gibson I, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection. Journal Of Clinical Investigation 2026 PMID: 42262888, DOI: 10.1172/jci193173.Peer-Reviewed Original ResearchT cell receptorT cellsCD8+T cellsCanonical T cell receptorsSingle-cell transcriptomicsCD8+T cell activityCD8+T cell infiltrationT cell receptor stimulationBulk transcriptomesT cell functionT cell receptor signalingKidney transplant cohortPhysiological expressionAPOL1 risk allelesKidney transplant rejectionRisk of kidney diseaseExpression of wild typeTacrolimus levelsCardiac transplantationAllograft rejectionTransplant cohortER-Ca2Kidney rejectionTransplant rejectionCytokine productionConcurrent Manifestation of Crescentic Anti-glomerular Basement Membrane Nephritis and Membranous Nephropathy
Vellaisamy G, Kumar A, Singh J, Nada R. Concurrent Manifestation of Crescentic Anti-glomerular Basement Membrane Nephritis and Membranous Nephropathy. Indian Journal Of Kidney Diseases 2026, 5: 123-126. DOI: 10.4103/ijkd.ijkd_6_26.Peer-Reviewed Original ResearchMembranous nephropathyAnti-glomerular basement membrane nephritisConcurrent manifestationAnti-glomerular basement membraneSevere renal dysfunctionEnd-stage renal diseaseAnti-GBM nephritisRenal outcomesMembranous nephritisRenal dysfunctionSerum creatinineRenal functionCrescentic glomerulonephritisRenal diseaseNephritisBasement membraneNephropathy
2025
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.Peer-Reviewed Original ResearchConceptsROCK activitySmall molecule inhibitorsSHROOM3Wild typeAssociated with renal fibrosisCo-expressionRisk allelesTransgenic toolsPleiotropic effectsROCK inhibitionRho-kinaseOverexpressionCell linesPrecision therapeuticsFibroblast linesProfibrotic functionProfibrotic signalingMotifKidney diseaseEnhanced variantRenal fibrosisTubular cellsAlbuminuriaIn vivoMiceDesign and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx.
Kumar A, Barsotti G, Yi Z, Sun Z, Reghuvaran A, Tanvir EM, Pell J, Shi H, Perincheri S, Shaw M, Kent C, Javed D, Leite P, Jayaram D, Turner J, Meliambro K, Luciano R, He JC, Moledina D, Wilson P, Zhang W, Menon MC. Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx. MedRxiv 2025 PMID: 41282816, DOI: 10.1101/2025.10.31.25338655.Peer-Reviewed Original ResearchImmunotactoid Glomerulonephritis Unmasked From C3 Glomerulopathy: A Diagnostic Dilemma in Spectrum of MGRS
Vellaisamy G, Lad D, Ramachandran R, Kumar A, Nada R. Immunotactoid Glomerulonephritis Unmasked From C3 Glomerulopathy: A Diagnostic Dilemma in Spectrum of MGRS. Indian Journal Of Kidney Diseases 2025, 4: 149-151. DOI: 10.4103/ijkd.ijkd_29_25.Peer-Reviewed Original ResearchImmunotactoid glomerulonephritisMembranoproliferative patternMembranoproliferative pattern of glomerular injuryC3 depositionDiagnosis of C3 glomerulopathyPattern of glomerular injuryCryoglobulinemic glomerulonephritisIgG-kappaSerum cryoglobulinsDiagnostic dilemmaKappa restrictionAdult patientsC3 glomerulopathyGlomerular injuryPolyclonal immunoglobulinsParaffin sectionsGlomerulonephritisChemotherapyDiagnosisGlomerulopathyPatientsIgGVincristine in FSGS: Rediscovering an Old Therapeutic for FSGS
Kumar A, Prasad P, Menon M. Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS. Kidney International Reports 2025, 10: 3727-3729. PMID: 41278331, PMCID: PMC12640027, DOI: 10.1016/j.ekir.2025.09.018.Commentaries, Editorials and LettersA T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection.
Pell J, Tanvir EM, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Chaar SA, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, Kumar B, Song W, He C, Pober JS, Somlo S, Gibson IW, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon MC. A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. BioRxiv 2025 PMID: 40791557, DOI: 10.1101/2025.07.14.664793.Peer-Reviewed Original ResearchAuthor Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1712-1712. PMID: 40234733, DOI: 10.1038/s41591-025-03706-7.Commentaries, Editorials and LettersLILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1677-1687. PMID: 40065170, PMCID: PMC12527113, DOI: 10.1038/s41591-025-03568-z.Peer-Reviewed Original ResearchSingle-nucelotide polymorphismsAssociated with death-censored graft lossDeath-censored graft lossGenetic variationGraft lossImmunoreceptor tyrosine-based inhibitory motifTyrosine-based inhibitory motifAA individualsApolipoprotein L1Rate of graft lossEnd-stage renal diseaseMissense mutationsInhibitory motifRNA sequencingKidney transplant outcomesKidney transplant failureMultiomics analysisImmune-related diseasesAmino acidsAfrican American recipientsTransplant cohortTransplant failureTransplant outcomesAnalysis of bloodProspective studyWCN25-3225 APOLIPOPROTIEN E IN C3 GLOMERULOPATHAY-A VALIDATION
DUSEJA R, KUMAR A, RAMACHANDRAN R. WCN25-3225 APOLIPOPROTIEN E IN C3 GLOMERULOPATHAY-A VALIDATION. Kidney International Reports 2025, 10: s361-s362. DOI: 10.1016/j.ekir.2024.11.674.Peer-Reviewed Original Research
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Yale School of Medicine
Internal Medicine-Nephrology, The Anlyan Center, 1 Gilbert Street
New Haven, Connecticut 06519
United States