Arya Aminorroaya, MD, MPH
Hospital ResidentAbout
Research
Publications
2026
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes
Kim C, Bu F, Blacketer C, Ostropolets A, Duarte-Salles T, Viernes B, Falconer T, Pistillo A, Li J, Yin C, Van Zandt M, Nagy P, Nishimura A, Minty E, You S, Sawano M, Sawano S, Jeon J, Aminorroaya A, Dhingra L, Pedroso A, Thangaraj P, Dorr D, Pratt N, Man K, Lau W, Morales D, Khera R, Schuemie M, Ryan P, Hripcsak G, Krumholz H, Suchard M, Lu Y. Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes. Nature Communications 2026 PMID: 41935054, DOI: 10.1038/s41467-026-71307-0.Peer-Reviewed Original ResearchGLP-1 receptor agonistsReceptor agonistsAntihyperglycemic agentsGLP-1SGLT2 inhibitorsClinical trialsComparative safetyRisk of diabetic ketoacidosisHigh riskHigher risk of diabetic ketoacidosisRisk of peripheral edemaMultinational cohort studyRisk of hypoglycemiaDPP-4 inhibitorsPropensity score adjustmentType 2 diabetesPeripheral edemaDiabetic ketoacidosisAdverse eventsCohort studyHazard ratioDPP-4Safety outcomesAgonistsReal-world evidenceComparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus
Bu F, Wu R, Ostropolets A, Aminorroaya A, Chen H, Chai Y, Dhingra L, Falconer T, Hsu J, Kim C, Lau W, Man K, Minty E, Morales D, Nishimura A, Thangraraj P, Van Zandt M, Yin C, Khera R, Hripcsak G, Suchard M. Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus. Journal Of The American College Of Cardiology 2026 PMID: 41984016, DOI: 10.1016/j.jacc.2026.02.5123.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2 inhibitorsGlucagon-like peptide 1 receptor agonistsPeptide 1 receptor agonistsComparative effectiveness assessmentCompare cardiovascular effectsCardiovascular diseaseGLP-1RACardiovascular effectsElectronic health record databaseSodium-glucoseRandom-effects meta-analysisGLP-1RAsHealth record databaseCardiovascular benefitsCardiovascular disease subgroupsCox proportional hazards modelsEstablished cardiovascular diseaseSecondary subgroup analysisSecond-line therapyEffects of glucagon-like peptide 1 receptor agonistsMeta-analytic estimatesProportional hazards modelType 2 diabetes mellitusCardiovascular outcome trialsPropensity score adjustmentArtificial Intelligence-enhanced Electrocardiography for Heart Failure Screening and Risk Stratification
Dhingra L, Croon P, Batinica B, Aminorroaya A, Pedroso A, Khera R. Artificial Intelligence-enhanced Electrocardiography for Heart Failure Screening and Risk Stratification. Current Heart Failure Reports 2026, 23: 10. PMID: 41838300, DOI: 10.1007/s11897-026-00748-x.Peer-Reviewed Original ResearchRisk factor surveillancePublic health challengeHeart failure screeningHF risk assessmentHF screeningRoutine careCommunity programsHF riskHealth challengesECG testRisk scoreECG interpretationRisk stratificationConfirmatory imagingSymptom onsetRiskCost-effectiveClinical implementationProspective validationScreeningTherapy decisionsFunctional abnormalitiesCareRisk assessmentCohortArtificial intelligence-based automated interpretation of images of electrocardiograms: development and multinational validation of ECG-GPT
Khunte A, Sangha V, Oikonomou E, Dhingra L, Aminorroaya A, Coppi A, Shankar S, Rockers E, Mortazavi B, Bhatt D, Krumholz H, Al-Kindi S, Nadkarni G, Vaid A, Khera R. Artificial intelligence-based automated interpretation of images of electrocardiograms: development and multinational validation of ECG-GPT. European Heart Journal - Digital Health 2026, 7: ztag031. PMID: 41853639, PMCID: PMC12993923, DOI: 10.1093/ehjdh/ztag031.Peer-Reviewed Original ResearchBundle branch blockEncoder-decoder modelBranch blockFascicular blockUS health systemClinical assessmentLeft anterior fascicular blockRight bundle branch blockLeft posterior fascicular blockAssessment of electrocardiogramsLeft bundle branch blockAnterior fascicular blockPosterior fascicular blockPremature atrial contractionsPremature ventricular contractionsHealth systemPTB-XL datasetLow-resource settingsAtrioventricular blockConduction abnormalitiesSinus bradycardiaAtrial contractionSinus tachycardiaAtrial fibrillationDiagnosis statementsA real-world evaluation of longitudinal healthcare expenses in a health system registry of type-2 diabetes mellitus and cardiovascular disease enabled by the 21st century cures act
Dhingra L, Pedroso A, Aminorroaya A, Rajpura J, Mehanna S, Tonnu-Mihara I, Khera R. A real-world evaluation of longitudinal healthcare expenses in a health system registry of type-2 diabetes mellitus and cardiovascular disease enabled by the 21st century cures act. American Journal Of Preventive Cardiology 2026, 25: 101425. PMID: 41767452, PMCID: PMC12946900, DOI: 10.1016/j.ajpc.2026.101425.Peer-Reviewed Original ResearchFinancial hardshipHealthcare expensesObservational cohort studyHealthcare eventsHealthcare spendingPrevalence of financial hardshipAtherosclerotic cardiovascular diseaseYale New Haven Health SystemDiverse cohortDiverse cohort of individualsReal world evaluationCardiovascular diseaseMedian household incomeUS Census dataCohort study of patientsMultivariate logistic regressionCohort of individualsHealthcare visitsRegular careObservational cohort study of patientsHealth systemT2D diagnosisType 2 diabetes mellitusOutpatient networkResidential zipMachine learning to predict elevated lipoprotein(a)
Aminorroaya A, Khera R. Machine learning to predict elevated lipoprotein(a). Current Opinion In Lipidology 2026, 37: 58-64. PMID: 41631372, DOI: 10.1097/mol.0000000000001024.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular diseasePopulation-based settingLifelong risk factorLp(a)Cardiovascular risk assessmentUK BiobankHealth systemGuideline supportIdentification of individualsDemographic subgroupsUS cohortCase findingRoutine cardiovascular risk assessmentTesting recommendationsRisk factorsCardiovascular diseaseClinical practiceOne-time testingClinical variablesSystematic identificationLearning-based strategyIndividualsBiobankMachine learning-based strategyHealthTARGET-AI: A Foundational Approach for the Targeted Deployment of Artificial Intelligence Electrocardiography in the Electronic Health Record
Oikonomou E, Batinica B, Dhingra L, Aminorroaya A, Coppi A, Khera R. TARGET-AI: A Foundational Approach for the Targeted Deployment of Artificial Intelligence Electrocardiography in the Electronic Health Record. NEJM AI 2026, 3 DOI: 10.1056/aioa2500588.Peer-Reviewed Original ResearchFollow-Up Assessment of Adherence to Methodological Standards in National Inpatient Sample Research
Dhingra L, Pedroso A, Aminorroaya A, Caraballo C, Mahajan S, Bansal B, Krumholz H, Khera R. Follow-Up Assessment of Adherence to Methodological Standards in National Inpatient Sample Research. JAMA Network Open 2026, 9: e2555753. PMID: 41591780, PMCID: PMC12848622, DOI: 10.1001/jamanetworkopen.2025.55753.Peer-Reviewed Original ResearchArtificial Intelligence Electrocardiogram Risk Tool—Reply
Dhingra L, Aminorroaya A, Khera R. Artificial Intelligence Electrocardiogram Risk Tool—Reply. JAMA Cardiology 2026, 11: 109-109. PMID: 41259010, DOI: 10.1001/jamacardio.2025.4246.Peer-Reviewed Original Research
2025
Evaluating the Accessibility of Transcatheter and Surgical Aortic Valve Replacement Across the US Via Driving-Times
Kapadia S, Shen M, Hanna J, Wheelock K, Pedroso A, Vora A, Dhingra L, Aminorroaya A, Khera R. Evaluating the Accessibility of Transcatheter and Surgical Aortic Valve Replacement Across the US Via Driving-Times. The American Journal Of Cardiology 2025, 262: 61-67. PMID: 41475454, DOI: 10.1016/j.amjcard.2025.12.007.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementTranscatheter aortic valve replacement centersValve replacementMinimally invasive alternativeMedian ageMedian driving timeInvasive alternativeTAVR centersZip codesDisadvantaged rural communitiesHighest proportionSociodemographic correlatesProportion of beneficiariesTranscatheterMixed-effects modelsLinear mixed-effects modelsRural communities
Academic Achievements & Community Involvement
News & Links
News
- April 28, 2026
Choosing Safer Diabetes Medications for Older Adults
- March 16, 2026
Yale School of Medicine Faculty To Present New Cardiovascular Research at National Cardiology Conference
- February 11, 2026
Using AI to Guide AI
- December 12, 2025
Resident Roundup: Arya Aminorroaya, MD, MPH