2021
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2019
Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction
Angraal S, Mortazavi BJ, Gupta A, Khera R, Ahmad T, Desai NR, Jacoby DL, Masoudi FA, Spertus JA, Krumholz HM. Machine Learning Prediction of Mortality and Hospitalization in Heart Failure With Preserved Ejection Fraction. JACC Heart Failure 2019, 8: 12-21. PMID: 31606361, DOI: 10.1016/j.jchf.2019.06.013.Peer-Reviewed Original ResearchConceptsHF hospitalizationRisk of mortalityEjection fractionBlood urea nitrogen levelsLogistic regressionPrevious HF hospitalizationHeart failure hospitalizationReduced ejection fractionReceiver-operating characteristic curveRisk of deathBody mass indexBlood urea nitrogenUrea nitrogen levelsHealth status dataMean c-statisticKCCQ scoresTOPCAT trialFailure hospitalizationHeart failureHemoglobin levelsMass indexC-statisticHospitalizationUrea nitrogenMortalityNational Trends in Healthcare-Associated Infections for Five Common Cardiovascular Conditions
Miller PE, Guha A, Khera R, Chouairi F, Ahmad T, Nasir K, Addison D, Desai NR. National Trends in Healthcare-Associated Infections for Five Common Cardiovascular Conditions. The American Journal Of Cardiology 2019, 124: 1140-1148. PMID: 31371062, PMCID: PMC7883647, DOI: 10.1016/j.amjcard.2019.06.029.Peer-Reviewed Original ResearchConceptsLength of stayCommon cardiovascular conditionCentral line-associated bloodstream infectionsCatheter-associated urinary tract infectionsLine-associated bloodstream infectionsUrinary tract infectionVentilator-associated pneumoniaClostridium difficile infectionCardiovascular conditionsTract infectionsBloodstream infectionsDifficile infectionOutcome of HAICoronary artery bypassTotal hospital chargesAcute myocardial infarctionSkilled care facilityHealthcare-Associated InfectionsValue-based careHospital mortalityArtery bypassCardiogenic shockHeart failurePropensity matchingAtrial fibrillationDiagnostic and prognostic utility of cardiac troponin in post-cardiac arrest care
Agusala V, Khera R, Cheeran D, Mody P, Reddy PP, Link MS. Diagnostic and prognostic utility of cardiac troponin in post-cardiac arrest care. Resuscitation 2019, 141: 69-72. PMID: 31201884, DOI: 10.1016/j.resuscitation.2019.06.004.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionIschemic etiologyInitial cTnTPeak cTnTCardiac troponinPost-cardiac arrest settingRetrospective single-center registryPost-cardiac arrest careVentricular systolic dysfunctionSingle-center registryTroponin T testingSystolic dysfunctionCenter registryConsecutive patientsSpontaneous circulationArrest carePrognostic utilityCardiac arrestMean agePatient outcomesExpert adjudicationEtiologyCTnTDiagnostic testsT-testingPulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children
Khera R, Tang Y, Girotra S, Nadkarni VM, Link MS, Raymond TT, Guerguerian AM, Berg RA, Chan PS, Investigators F. Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children. Circulation 2019, 140: 370-378. PMID: 31006260, PMCID: PMC6663562, DOI: 10.1161/circulationaha.118.039048.Peer-Reviewed Original ResearchConceptsPulseless cardiac arrestHospital cardiac arrestCardiac arrestCardiopulmonary resuscitationPediatric patientsHospitalized childrenPoor perfusionHospital dischargeMinutes of CPRPredictors of survivalRate of progressionMultilevel Poisson regression modelsYears of ageRate of survivalPoisson regression modelsRisk-adjusted ratesGuidelines-ResuscitationPostresuscitation careResuscitation attemptsBradycardiaHigh riskPulseless arrestChest compressionsPulselessnessCPR eventsAssociation of access to exercise opportunities and cardiovascular mortality
Angraal S, Gupta A, Khera R, Nasir K, Desai NR. Association of access to exercise opportunities and cardiovascular mortality. American Heart Journal 2019, 212: 152-156. PMID: 31051426, DOI: 10.1016/j.ahj.2019.02.010.Peer-Reviewed Original ResearchConceptsCVD mortalityLower CVD mortalityCardiovascular disease mortalityLeisure physical activityExercise opportunitiesAssociation of accessCardiovascular mortalityDisease mortalityHigh prevalencePhysical activityExercise facilitiesMortalityHigh accessHigh percentageLow accessObesityDiabetesPrevalence
2017
Comparison of Readmission Rates After Acute Myocardial Infarction in 3 Patient Age Groups (18 to 44, 45 to 64, and ≥65 Years) in the United States
Khera R, Jain S, Pandey A, Agusala V, Kumbhani DJ, Das SR, Berry JD, de Lemos JA, Girotra S. Comparison of Readmission Rates After Acute Myocardial Infarction in 3 Patient Age Groups (18 to 44, 45 to 64, and ≥65 Years) in the United States. The American Journal Of Cardiology 2017, 120: 1761-1767. PMID: 28865892, PMCID: PMC5825232, DOI: 10.1016/j.amjcard.2017.07.081.Peer-Reviewed Original ResearchConceptsYounger age groupsLow-income patientsReadmission ratesAge groupsHigh hospitalization burdenIndex AMI hospitalizationNationwide Readmissions DatabaseRisk of readmissionPatient age groupsAcute myocardial infarctionVulnerable patient groupSignificant resource utilizationMultivariable hierarchical modelsYears of ageHealth care resourcesHealth care systemReadmission periodHospitalization burdenPayer databaseAMI survivorsPost-AMIPatient groupInpatient hospitalizationMyocardial infarctionReadmission
2016
Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest
Khera R, Chan PS, Donnino M, Girotra S. Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest. Circulation 2016, 134: 2105-2114. PMID: 27908910, PMCID: PMC5173427, DOI: 10.1161/circulationaha.116.025459.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestEpinephrine administrationCardiac arrestFunctional recoveryHospital variationNonshockable rhythmsHospital ratesSurvival rateRisk-standardized survival ratesIn-Hospital Cardiac ArrestHospital-level outcomesRisk-standardized ratesDose of epinephrineMedian survival rateOdds of delayHigh rateGuidelines-ResuscitationAdult patientsOverall survivalWorse survivalSimilar patientsLowest quartileImproved outcomesHospitalPatients
2015
Trends in hospitalization for takotsubo cardiomyopathy in the United States
Khera R, Light-McGroary K, Zahr F, Horwitz PA, Girotra S. Trends in hospitalization for takotsubo cardiomyopathy in the United States. American Heart Journal 2015, 172: 53-63. PMID: 26856216, PMCID: PMC4748175, DOI: 10.1016/j.ahj.2015.10.022.Peer-Reviewed Original ResearchConceptsTakotsubo cardiomyopathyPrimary diagnosis groupCardiac arrestDiagnosis groupsHigh incidenceCardiogenic shockRespiratory failurePsychiatric disordersTransient left ventricular systolic dysfunctionLeft ventricular systolic dysfunctionNational Inpatient Sample dataCardiovascular risk factorsDiagnostic coronary angiographyVentricular systolic dysfunctionSecondary discharge diagnosisRisk of mortalityCost of careHospital mortalitySystolic dysfunctionCritical illnessCoronary angiographyDischarge diagnosisRisk factorsExcess mortalitySecondary groupUse of Mechanical Circulatory Support in Percutaneous Coronary Intervention in the United States
Khera R, Cram P, Vaughan-Sarrazin M, Horwitz PA, Girotra S. Use of Mechanical Circulatory Support in Percutaneous Coronary Intervention in the United States. The American Journal Of Cardiology 2015, 117: 10-16. PMID: 26547292, PMCID: PMC4690753, DOI: 10.1016/j.amjcard.2015.10.005.Peer-Reviewed Original ResearchConceptsPercutaneous ventricular assist devicePercutaneous coronary interventionIntraaortic balloon pumpMechanical circulatory supportHigh-risk percutaneous coronary interventionHospital mortalityIABP recipientsCoronary interventionCirculatory supportPropensity-matched analysisChronic kidney diseaseNinth Edition codesNational Inpatient SampleAcute myocardial infarctionVentricular assist deviceCardiogenic shockUnadjusted mortalityBalloon pumpHeart failureRandomized trialsEdition codesMechanical ventilationKidney diseaseMyocardial infarctionInpatient Sample
2009
Diffuse large B-cell lymphoma: experience from a tertiary care center in north India
Khera R, Jain S, Kumar L, Thulkar S, Vijayraghwan M, Dawar R. Diffuse large B-cell lymphoma: experience from a tertiary care center in north India. Medical Oncology 2009, 27: 310-318. PMID: 19350421, DOI: 10.1007/s12032-009-9211-2.Peer-Reviewed Original ResearchConceptsDiffuse large B-cell lymphomaB symptomsAnn Arbor stage IV diseaseRetrospective case record studyMedian event-free survivalLarge B-cell lymphomaClinico-laboratory characteristicsMedian overall survivalUnfavorable prognosis groupStage IV diseaseEvent-free survivalSerum albumin levelTertiary care centerClinico-pathological presentationErythrocyte sedimentation rateCase record studyB-cell lymphomaFree survivalAlbumin levelsMedian ageOverall survivalPatient characteristicsPrognostic factorsHemoglobin levelsPrognosis group