Rohan Khera, MD, MS
Assistant Professor of Medicine (Cardiovascular Medicine) and of Biostatistics (Health Informatics)Cards
About
Titles
Assistant Professor of Medicine (Cardiovascular Medicine) and of Biostatistics (Health Informatics)
Clinical Director, Center for Health Informatics and Analytics, YNHH/Yale CORE; Director, Cardiovascular Data Science (CarDS) Lab
Biography
Dr. Khera is a Cardiologist and Data Scientist and the Director of the Cardiovascular Data Science (CarDS) Lab, which is a multidisciplinary group focusing on data-driven discovery in cardiovascular disease. He is the Clinical Director of the Center for Health Informatics and Analytics at the Yale Center for Outcomes Research and Evaluation. He is also an Associate Editor for Artificial Intelligence and Digital Health at JAMA.
The CarDS Lab, which Dr. Khera leads, is developing and implementing strategies to improve outcomes for patients with or at risk for cardiovascular disease through data-driven innovations in delivering evidence-based, patient-centered care. Dr. Khera’s work focuses on novel applications in medical informatics, machine learning, and artificial intelligence to evaluate patient care and develop precision care solutions. His work spans broad digital data sources, including electronic health records, electrocardiography, cardiovascular imaging, and wearable devices, with applications to modernize US and global healthcare. The work in his Lab is supported by grants from the National Institutes of Health and the Doris Duke Charitable Foundation.
Dr. Khera graduated from the All-India Institute of Medical Sciences as a National Young Investigator Scholarship awardee. During his internal medicine residency training at the University of Iowa and his cardiology fellowship training at UT Southwestern Medical Center, Dr. Khera received the American College of Cardiology’s Young Investigator Award and the Francois Abboud Young Investigator Award, in addition to being inducted into the Alpha Omega Alpha Medical Honor Society. For his work at Yale, Dr. Khera received the 2023 ASCI Young Physician-Scientist Award, the 2023 Blavatnik Award, and the 2021 Jeremiah Stamler Award.
More details on his work can be found at www.cards-lab.org.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondaryBiostatistics
Assistant ProfessorSecondary
Other Departments & Organizations
- Big Data Summer Immersion at Yale
- Biomedical Informatics & Data Science
- Biostatistics
- Cardiovascular Data Science Lab (CarDS)
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Computational Biology and Biomedical Informatics
- Internal Medicine
- Janeway Society
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale School of Public Health
- Yale UNRAVEL Study
Education & Training
- Fellowship
- UT Southwestern Medical Center (2020)
- MS
- UT Southwestern Medical Center (2019)
- Clinical Scholar
- UT Southwestern Medical Center (2019)
- Residency
- University of Iowa Carver College of Medicine (2016)
- Internship
- University of Iowa Carver College of Medicine (2014)
- MD
- All India Institute of Medical Sciences (2011)
Research
Overview
Dr. Khera's clinical observations have informed his research, which has been featured in leading medical and cardiovascular journals.
- First, he has pursued data-driven strategies to evaluate the quality of care measures and their association with patient outcomes in those hospitalized with cardiovascular disease.
- Second, he and his team have developed novel strategies that employ machine learning to infer personalized effect estimates from clinical trials using computational phenomaps.
- Third, he has led the application of deep learning and artificial intelligence to electrocardiography and cardiac imaging.
- Fourth, he has led the development of data-driven quality measurement programs in cardiovascular diseases in large national datasets.
- Finally, he has conducted methodological investigations that focus on improving the rigor of studies that use large datasets.
A key focus of his ongoing work is digital phenotyping of cardiovascular disease and the development of automated assays of care quality within the electronic health record. The work is specifically designing and implementing clinical decision support with a mixed quantitative-qualitative research methodology that incorporates inputs from patients and clinicians in retrieving information and designing interventions. His group has developed a series of applications of machine learning to clinical data. These tools have been validated in multinational populations and are designed to increase efficiency and personalization of care.
Medical Research Interests
Academic Achievements & Community Involvement
Clinical Care
Overview
Rohan Khera, MBBS (a medical degree awarded in several countries outside the U.S.), is a cardiologist who studies the use of data and artificial intelligence to determine the best therapies for patients with heart issues.
His work explores the use of “digital phenotyping,” or data from devices like personal smartphones. The information found there—including data regarding activity, social interactions, and day-to-day behaviors—can be combined with information from patients’ electronic health records to determine treatment possibilities.
Often, physicians use a simple questionnaire to determine patient risk for cardiovascular issues. One of Dr. Khera’s studies suggests that using a patient’s electronic medical record can produce substantially more accurate predictions.
As leader of the Cardiovascular Data Science (CarDS) Lab, Dr. Khera heads a multidisciplinary group focused on data-driven learning in heart disease. Some of his work helps teams evaluate how accurately patients are diagnosed and treated. The group also designs new treatments and examines whether physicians follow what is considered best care.
Dr. Khera has published articles in leading medical journals, including The Journal of the American Medical Association, The BMJ, Circulation, and Nature Communications.
Additionally, Dr. Khera has received numerous awards, including Young Investigator awards from the American College of Cardiology and the American Heart Association Resuscitation Science. The National Heart, Lung, and Blood Institute awarded Dr. Khera a career development grant to develop automated tools for better care for heart patients.
Clinical Specialties
Board Certifications
Clinical Informatics
- Certification Organization
- AB of Preventive Medicine
- Original Certification Date
- 2024
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2020
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
News & Links
News
- May 14, 2025Source: Yale Medicine Magazine
Chatbot Revolution: From Me-LLaMA to GutGPT, YSM researchers leverage LLMs
- February 04, 2025Source: NewsBreak
Yale researchers use AI in studies regarding heart and mental health
- January 31, 2025
AI Can Identify Cardiomyopathies Early, Says New Study
- January 28, 2025Source: CNN
How I went from Apple Watch skeptic to devotee in one health scare
Get In Touch
Contacts
Cardiovascular Data Science Lab (CarDS)
300 George St
New Haven, Connecticut 06510
United States
Locations
Center for Outcomes Research and Evaluation
Academic Office
195 Church Street, Fl 5th Floor
New Haven, CT 06510
195 Church Street
Lab
Fl 6th
New Haven, CT 06510
Events
Everyone Giorgio Mottola, MD - Cate Wright, MD
Everyone Shan Parikh, MD, PhD - Kene Mezue, MD, MSc
Everyone Michelle Kittleson, MD, PhD
Everyone Speakers to be announced.